Patents by Inventor Miall Cedilote

Miall Cedilote has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of 5-[2-[7 (trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo [1,5-A]pyrimidin-3-yl[ethynyl]-2-pyridinamine
    Patent number: 9447099
    Abstract: The present invention provides methods for preparing 5-[2-[7-(trifluoromethyl)-5-[4-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]ethynyl]-2-pyridinamine (compound A), which is useful for the treatment of depression and other CNS disorders. The present methods are useful for preparing compound A on large scale in manufacturing facilities.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: September 20, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stephan Bachmann, Daniel Bailey, Jodie Brice, Miall Cedilote, Zhiming Dong, Stefan Hildbrand, Doreen Miller, Paul Spurr, Amit Srivastava, Juergen Wichmann, Thomas Woltering, Jason Yang, Pingsheng Zhang
  • Methods for the preparation of N-(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide hydrochloride salt
    Patent number: 8242276
    Abstract: The present invention provides novel methods for preparing N—(S)-1 -azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 1, a nicotinic ?-7 receptor ligand, that are useful for the scaled-up preparation of compound 1. Compound 1 is useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: August 14, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jodie Brice, Miall Cedilote, Zhiming Dong, Pingsheng Zhang
  • METHODS FOR THE PREPARATION OF N-(S)-1-AZABICYCLO[2.2.2]OCT-3-YL-1H-INDAZOLE-3-CARBOXAMIDE HYDROCHLORIDE SALT
    Publication number: 20120004412
    Abstract: The present invention provides novel methods for preparing N—(S)-1-azabicyclo[2.2.2]oct-3-yl-1H-indazole-3-carboxamide HCl salt 1, a nicotinic ?-7 receptor ligand, that are useful for the scaled-up preparation of compound 1. Compound 1 is useful in the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain, such as for the treatment of Alzheimer's disease and schizophrenia, as well as other psychiatric and neurological disorders.
    Type: Application
    Filed: June 23, 2011
    Publication date: January 5, 2012
    Inventors: Jodie Brice, Miall Cedilote, Zhiming Dong, Pingsheng Zhang
  • Process for the preparation of 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-gamma-lactone
    Patent number: 7838693
    Abstract: The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-?-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: November 23, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Miall Cedilote, Thomas Cleary, Hans Iding, Pingsheng Zhang
  • Mono-nitration of aromatic compounds via nitrate salts
    Patent number: 7429589
    Abstract: A method of nitrating a compound selected from the group consisting of is provided.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: September 30, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Miall Cedilote, Thomas Patrick Cleary, Pingsheng Zhang
  • NOVEL PROCESS FOR THE PREPARATION OF (2R)-2-DEOXY-2-FLUORO-2-METHYL-D-ERYTHRO-PENTONO-GAMMA-LACTONE AND (2S)-2-DEOXY-2-FLUORO-2-METHYL-D-ERYTHRO-PENTONO-GAMMA-LACTONE
    Publication number: 20080177079
    Abstract: The present invention provides novel methods for preparing compounds (2R)-2-deoxy-2-fluoro-2-methyl-D-erythro-pentono-?-lactone (11) and (2S)-2-deoxy-2-fluoro-2-methyl-D-erythro-pentono-?-lactone (12), which are intermediates for preparing a key intermediate 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-?-lactone (B), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl)cytosine (A), which is a potent and selective anti-hepatitis C virus agent.
    Type: Application
    Filed: January 15, 2008
    Publication date: July 24, 2008
    Inventors: Miall Cedilote, Thomas Cleary, Pingsheng Zhang
  • NOVEL PROCESS FOR THE PREPARATION OF 3,5-DI-O-ACYL-2-FLUORO-2-C-METHYL-D-RIBONO-GAMMA-LACTONE
    Publication number: 20080145901
    Abstract: The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-?-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.
    Type: Application
    Filed: December 11, 2007
    Publication date: June 19, 2008
    Inventors: Miall Cedilote, Thomas Cleary, Hans Iding, Pingsheng Zhang
  • Mono-nitration of aromatic compounds via nitrate salts
    Publication number: 20070255057
    Abstract: A method of nitrating a compound selected from the group consisting of is provided.
    Type: Application
    Filed: February 27, 2007
    Publication date: November 1, 2007
    Inventors: Miall Cedilote, Thomas Patrick Cleary, Pingsheng Zhang