Patents by Inventor Mian Li

Mian Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11987852
    Abstract: The embodiment of the present disclosure provides a method for crystallizing compound sugar solution of xylose and sucrose, including: introducing a mixed solution of sucrose crystals, xylose crystals and water into a crystallization device, setting a stirring speed in a range of 60 rpm-120 rpm, a temperature in a range of 75° C.-80° C., a vacuum pump pressure in a range of 50 mbar-200 mbar, evaporating the mixed solution until a Brix value of the mixed solution reaches a range of 78 Brix-81 Brix, and stopping the vacuum evaporation, adjusting the temperature to a range of 70° C.-75° C., dropwise adding food-grade isopropanol solution or ethanol solution to the evaporated mixed solution, adding sucrose seed crystals, and continuing stirring to obtain a solution, when small seed crystals grow in the solution, dropping the temperature to a range of 40° C.-60° C. at a rate of 10° C./h, and then stirring for 6 h to obtain the mixed sugar solution; centrifuging and drying at 40° C.-60° C.
    Type: Grant
    Filed: July 6, 2023
    Date of Patent: May 21, 2024
    Assignee: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD
    Inventors: Shufang Qin, Mian Li, Qiang Wu, Wulong Yang, Huan Zhou, Yinyin Liu, Jiangen Yan
  • Publication number: 20240093247
    Abstract: A genetically engineered strain of Z. mobilis and uses thereof are provided. The genetically engineered strain named ZMNP is obtained by knockouts of four endogenous plasmids of pZM32, pZM32, pZM36, pZM33, and pZM39 from strain ZM4-Cas12a. ZMNP contains a reduced genome and has a series of excellent traits, such as high transformation efficiency, enhanced tolerance to inhibitors, improved capability to use secondary mother liquor and other excellent performance. ZMNP can be used as a chassis cell to construct diverse cell factories for biochemical production using different feedstocks especially the lignocellulosic biomass.
    Type: Application
    Filed: September 18, 2023
    Publication date: March 21, 2024
    Applicant: Hubei University
    Inventors: Shihui YANG, Binan GENG, Qiaoning HE, Jun DU, Mian LI
  • Publication number: 20240011057
    Abstract: The present invention relates to a method of preparing xylitol by using a xylose secondary mother liquor through fermentation. In the method, fermentation treatment is performed on a mixed liquid of the xylose secondary mother liquor and a xylose concentrate, and the xylose secondary mother liquor is subsequently batch-fed instead of glucose in the fermentation process. Thus, a glucose content in the fermentation system is stabilized, and some xylose is provided at the same time. In this way, the use amount of glucose and costs are reduced, and the system xylose can be relatively stabilized, thus improving the entire conversion rate. In the present invention, adding the xylose secondary mother liquor by mixed fermentation and batch feeding and the like enables the contents of heterosaccharides such as arabinose and mannose in the fermentation system to be always within a range of metabolization by fermenting strains, facilitating subsequent purification and improving the xylitol purity.
    Type: Application
    Filed: November 30, 2021
    Publication date: January 11, 2024
    Inventors: Xuhao Zeng, Jiaxing Luo, Jing Wang, Changhui Hu, Shuncheng Fang, Zhiqian Liu, Xue Cai, Xiaojian Zhang, Yuguo Zheng, Mian Li
  • Publication number: 20240010667
    Abstract: The present disclosure relates to a method for preparing liquid maltitol and liquid polyols from a raffinate including maltitol. The method comprises the following steps: obtaining a hydrogenated liquid by hydrogenating a pre-treated raffinate including maltitol, obtaining a post-treated liquid by post-treatment of the hydrogenated liquid to remove impurities, obtaining a dilute liquid and a concentrated maltitol solution by membrane-separation of the post-treated liquid, and using the dilute liquid as the liquid polyols, and obtaining the liquid maltitol by mixing the concentrated maltitol solution with a prepared maltitol solution with a maltitol content of over 50%, wherein the liquid maltitol has a maltitol content greater than or equal to 50% and meets a standard. Before the membrane separation process, the present disclosure reduces the reducing sugar content in the liquid by hydrogenation to lower the risk of yellowing during the process and to improve the quality of the final product.
    Type: Application
    Filed: September 18, 2023
    Publication date: January 11, 2024
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Yanhui YAO, Xinfeng HAN, Fuan WAN, Hang YUE, Weixing SHEN, Haojun DAI, Mingqian YANG, Mian LI
  • Patent number: 11866756
    Abstract: The embodiments of the present disclosure provides a method of co-producing erythritol and arabinose by using a xylose mother liquor, wherein an extract and a raffinate are obtained by separating the xylose mother liquor through a first chromatography, the extract is configured to prepare crystallized xylose, the raffinate and the liquid glucose or crystallized glucose are blended and erythritol is produced by using a Yarrowia lipolytica with high osmotolerant and a high conversion rate. erythritol crystals are obtained by centrifugation and crystallization first by using characteristics of low solubility degree and easy crystallization of the erythritol, the arabinose raffinate having a high content of arabinose is obtained by separating a centrifuged erythritol mother liquor through a second chromatography, and arabinose crystals are obtained based on the arabinose raffinate.
    Type: Grant
    Filed: July 18, 2023
    Date of Patent: January 9, 2024
    Assignee: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Aijuan Wu, Jiaxing Luo, Changhui Hu, Mingqian Yang, Chengjun Liao, Yi Zheng, Shuncheng Fang, Mian Li
  • Patent number: 11840501
    Abstract: The present invention relates to a xylitol preparation device integrating evaporation, crystallization and centrifugation, including a xylitol tank, a cleaning liquid tank, a recycling tank and a multiple distribution system, wherein the multiple distribution system includes J groups of evaporators for evaporation concentration, K groups of vacuum crystallization kettles for vacuum crystallization and L groups of centrifuges for centrifugation, wherein 2?J?6, 6?K?12 and 2?L?4; the evaporator, the vacuum crystallization kettle and the centrifuge in different groups are sequentially connected in series with one another through a pipeline and a valve respectively; by controlling on and off of each valve, a xylitol exchange liquid is switched and controlled between a series-connection mode and a parallel-connection mode in the multiple distribution system to enable evaporation, crystallization and separation processes to reach an optimal effect distribution so as to improve productivity.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: December 12, 2023
    Assignees: Zhejiang Huakang Pharmaceutical Co., Ltd., Zhejiang University, Zhejiang University of Technology
    Inventors: Jian Yang, Yi Zheng, Taogang Zhang, Han Gao, Mian Li, Zhiqiang Liu, Yuguo Zheng, Baoxing Mao, Xiaojian Zhang, Weiwei Fan
  • Publication number: 20230357805
    Abstract: The embodiments of the present disclosure provides a method of coproducing erythritol and arabinose by using a xylose mother liquor, wherein an extract and a raffinate are obtained by separating the xylose mother liquor through a first chromatography, the extract is configured to prepare crystallized xylose, the raffinate and the liquid glucose or crystallized glucose are blended and erythritol is produced by using a Yarrowia lipolytica with high osmotolerant and a high conversion rate. Erythritol crystals are obtained by centrifugation and crystallization first by using characteristics of low solubility degree and easy crystallization of the erythritol, the arabinose raffinate having a high content of arabinose is obtained by separating a centrifuged erythritol mother liquor through a second chromatography, and arabinose crystals are obtained based on the arabinose raffinate.
    Type: Application
    Filed: July 18, 2023
    Publication date: November 9, 2023
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Aijuan WU, Jiaxing LUO, Changhui HU, Mingqian YANG, Chengjun LIAO, Yi ZHENG, Shuncheng FANG, Mian LI
  • Publication number: 20230348350
    Abstract: The embodiment of the present disclosure provides a system for co-producing a xylitol and a caramel pigment by utilizing a xylose mother liquid, including an extraction assembly, a refined hydrogenation assembly and a browning reaction assembly. The extraction assembly is configured to obtain an extracted liquid and a raffinate liquid respectively by performing an initial extraction on the xylose mother liquid; the refined hydrogenation assembly is configured to prepare a crystal xylitol by performing a refined hydrogenation process on the extracted liquid; the browning reaction assembly is configured to prepare the caramel pigment by performing a browning reaction process on the raffinate liquid.
    Type: Application
    Filed: July 7, 2023
    Publication date: November 2, 2023
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Mian LI, Weidong XU, Deshui CHEN, Xinping CHENG, Chengjun LIAO, Qiang WU, Wulong YANG, Shufang QIN
  • Publication number: 20230348940
    Abstract: A system and method for producing cellulosic ethanol by biomass saccharification and fermentation is provided. The system includes a first reactor configured to carry out an enzymatic hydrolysis reaction of a biomass feedstock, a second reactor configured to carry out a fermentation reaction of the biomass feedstock, and a collection tank configured to collect the cellulosic ethanol. The first reactor and second reactor are provided with an enzymatic hydrolysis dosing pipe and a fermentation dosing pipe, respectively. An outlet of the first reactor is connected to an inlet of the second reactor through a fermentation pipe. An outlet of the second reactor is connected to an inlet of the first reactor through a discharge pipe that is provided with a first discharge pipe configured to discharge material from the second reactor. The first reactor is connected to an inlet of the collection tank through an ethanol pipe.
    Type: Application
    Filed: July 6, 2023
    Publication date: November 2, 2023
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Changhui HU, Jiaxing LUO, Mian LI, Chengjun LIAO, Wulong YANG, Liangcong YAN, Ni ZHEN, Lanlan CHEN
  • Publication number: 20230348349
    Abstract: The present disclosure provides a system and method for a refinement processing of xylitol fermentation broth. The system includes a fermentation component, a filtration and impurity removal component, and a refinement component. The fermentation component is configured to perform a fermentation processing on a raw material containing xylitol to obtain sediments and supernatant fermentation broth. The filtration and impurity removal component includes a ceramic membrane filter, a nanofiltration membrane filter, an activated carbon filter, and ion exchange columns. The ceramic membrane filter is configured to filter the supernatant fermentation broth to obtain ceramic membrane discharge liquid. The nanofiltration membrane filter is configured to perform a nanofiltration membrane filtration processing on the ceramic membrane discharge liquid to obtain nanofiltration liquid.
    Type: Application
    Filed: July 11, 2023
    Publication date: November 2, 2023
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Mian LI, Ni ZHEN, Jiaxing LUO, Changhui HU, Qiang WU, Wulong YANG, Fangming ZENG
  • Publication number: 20230345993
    Abstract: The present disclosure relates a method for preventing agglomeration in a mixture of xylitol and calcium aspartate. The method includes the following steps: first adjusting and measuring water activities of xylitol particles and calcium aspartate particles; then mixing the calcium aspartate particles with a water activity in a range of 0.50-0.52 with the xylitol particles with a water activity in a range of 0.48-0.56 to obtain a mixture of xylitol and calcium aspartate; or mixing the calcium aspartate particles with a water activity in a range of 0.52-0.58 with the xylitol particles with a water activity in a range of 0.50-0.60 to obtain a mixture of xylitol and calcium aspartate; or adding maltitol particles in a weight ratio of 5%-20% to a total mass of the xylitol particles and the maltitol particles to the mixture of xylitol and calcium aspartate.
    Type: Application
    Filed: July 5, 2023
    Publication date: November 2, 2023
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Baoxing MAO, Chengjun LIAO, Xiuxiu WANG, Ziyao WEI, Aijuan WU, Jiaxing LUO, Cui LIN, Mian LI
  • Publication number: 20230349012
    Abstract: The embodiment of the present disclosure provides a method for crystallizing compound sugar solution of xylose and sucrose, including: introducing a mixed solution of sucrose crystals, xylose crystals and water into a crystallization device, setting a stirring speed in a range of 60 rpm-120 rpm, a temperature in a range of 75° C.-80° C., a vacuum pump pressure in a range of 50 mbar-200 mbar, evaporating the mixed solution until a Brix value of the mixed solution reaches a range of 78 Brix-81 Brix, and stopping the vacuum evaporation, adjusting the temperature to a range of 70° C.-75° C., dropwise adding food-grade isopropanol solution or ethanol solution to the evaporated mixed solution, adding sucrose seed crystals, and continuing stirring to obtain a solution, when small seed crystals grow in the solution, dropping the temperature to a range of 40° C.-60° C. at a rate of 10° C./h, and then stirring for 6 h to obtain the mixed sugar solution; centrifuging and drying at 40° C.-60° C.
    Type: Application
    Filed: July 6, 2023
    Publication date: November 2, 2023
    Applicant: ZHEJIANG HUAKANG PHARMACEUTICAL CO., LTD.
    Inventors: Shufang QIN, Mian LI, Qiang WU, Wulong YANG, Huan ZHOU, Yinyin LIU, Jiangen YAN
  • Patent number: 11795517
    Abstract: Related to are a device and a method for performing continuous carbonation and impurity removal for xylose mother liquor.
    Type: Grant
    Filed: December 6, 2019
    Date of Patent: October 24, 2023
    Assignees: Zhejiang Huakang Pharmaceutical Co., Ltd., Zhejiang University of Technology
    Inventors: Jiaxing Luo, Guowei Luo, Chengjun Liao, Songtao Jiang, Yuan Zhou, Deshui Chen, Zhiqiang Liu, Xiaojian Zhang, Yuguo Zheng, Mian Li
  • Publication number: 20230326574
    Abstract: A method and system for recommending additional ingredients for making a nutritional preparation with improved folate retention. When an oxygen-reduced food processing step is used, an acidic pH value for the ingredients used improves folate retention. It is proposed to recommend additional or supplementary ingredients to reduce a pH value if a pH value of desired ingredient(s) is above or at a predetermined threshold.
    Type: Application
    Filed: February 3, 2020
    Publication date: October 12, 2023
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Bin Zhao, Jiani Tang, Mian Li, Yun Chen, Paul Bernard Joseph Higgins
  • Publication number: 20230313236
    Abstract: The present invention relates to a system for jointly producing erythritol and liquid sorbitol by using a corn starch, including a liquefaction tank, a saccharification tank, a filter and a nanofiltration assembly. The liquefaction tank is used to perform liquefaction for the corn starch, the saccharification tank is used to perform saccharification for the liquefied material, the filter is used to filter out impurities in the saccharified material to obtain a glucose liquid, and the nanofiltration assembly is used to perform nanofiltration for the filtered glucose liquid to respectively obtain a dialysate and a concentrate. The system further includes a fermentation and crystallization assembly for performing fermentation and crystallization for the dialysate to prepare crystalline erythritol, and a hydrogenation and evaporation assembly for performing hydrogenation and evaporation for the concentrate to prepare liquid sorbitol.
    Type: Application
    Filed: November 30, 2021
    Publication date: October 5, 2023
    Inventors: Yi Zheng, Aijuan Wu, Shuncheng Fang, Chengjun Liao, Lanlan Chen, Jiaxing Luo, Changhui Hu, Fangming Zeng, Mian Li
  • Publication number: 20230295677
    Abstract: The present invention provides a method of improving a biomass high-solid enzymatic hydrolysis rate. By screening particle sizes of the biomass substrate, different water content controls are performed on coarse and fine particle biomass substrates and then an entire water content of the mixture of the coarse and fine particle biomass substrates is controlled to achieve a reduced initial viscosity of the enzymatic hydrolysis and improve liquefaction speed, and finally improve the biomass high-solid enzymatic hydrolysis rate. The enzymatic hydrolysis system of the present invention can be easily constructed with lower equipment requirements, lower energy consumption, higher enzymatic hydrolysis efficiency and simpler operation process, helping the industrial production and applications.
    Type: Application
    Filed: November 30, 2021
    Publication date: September 21, 2023
    Inventors: Mian Li, Zhiqian Liu, Xuhao Zeng, Changhui Hu, Jing Wang, Xue Cai, Xiaojian Zhang, Yuguo Zheng
  • Publication number: 20230240344
    Abstract: The present invention relates to a sweetener liquid for preventing and relieving intestinal sugar alcohol intolerance. The sweetener liquid per 100ml includes 0.01 to 0.04 g of low-esterification pectin, 0.01 g to 0.1 g of ?-carrageenan, 0.01 g to 0.3 g of locust bean gum, 30 g to 60 g of xylitol, 5 g to 15 g of maltitol and 1 g to 10 g of sorbitol and remaining water; the low-esterification pectin is a pectin concentrate including, based on parts by weight, 15 parts of calcium citrate, 60 parts of low-molecular-weight pectin, 85 parts of ethylene glycol, 5 parts of carboxymethyl cellulose sodium and 30 parts of sodium citrate; the low-molecular-weight pectin includes a low-sugar fruit juice and a lemon juice; the sweetener liquid has a pH of 5-6.5 and a viscosity of 0.1 to 25 mPa•S. The present invention further provides a method of preparing a sweetener liquid and an application thereof.
    Type: Application
    Filed: November 30, 2021
    Publication date: August 3, 2023
    Inventors: Qile Zuo, Feifei Han, Xuan Zhu, Xinping Cheng, Mian Li, Lihua Shi, Wenyao Zhang, Yuan Wang
  • Publication number: 20230156301
    Abstract: Aspects of the present disclosure relate to systems and methods for image focusing for devices including multiple cameras. An example method includes estimating a focus distance associated with an image captured by a first camera, determining, based at least in part on the estimated focus distance, to switch from the first camera to a second camera, switching from the first camera to the second camera, completing a focusing operation using the second camera and presenting an updated image captured by the second camera.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 18, 2023
    Inventors: Wen-Chun FENG, Mian LI
  • Patent number: 11634656
    Abstract: The invention discloses a photocured medical catheter hydrophilic lubricating coating and a preparation method thereof. The hydrophilic lubricating coating comprises a primer coating and a lubricating coating. The primer coating is attached to the surface of a device, and the lubricating coating is attached to the primer coating. The primer coating comprises 1-10 parts by weight of one or more polyester acrylates, 50-90 parts by weight of one or more solvents, 0.5-5 parts by weight of one or more photoinitiators, 0.5-2 parts by weight of one or more wetting agents and 0.5-5 parts by weight of one or more reactive (or active) diluents. The lubricating coating comprises 1-10 parts by weight of one or more water soluble macromolecules, 1-5 parts by weight of one or more crosslinking (or crosslinked) macromolecules, 0-1 part by weight of one or more photoinitiators, 0.1-1 part by weight of one or more surfactants and 50-98 parts by weight of one or more solvents.
    Type: Grant
    Filed: July 2, 2020
    Date of Patent: April 25, 2023
    Assignee: OrbusNeich Medical PTE. LTD.
    Inventors: Jingjing Zhu, Songyun Xu, Mian Li, Chang Peng, Yirong Gong
  • Publication number: 20220395009
    Abstract: The present invention relates to an enteral sustained-release sugar alcohol additive including an inner layer structure and an outer layer structure. The inner layer structure contains components of xylitol and agar, and the outer layer structure contains components of carrageenan or gellan gum or xanthan gum or guar gum, vitamin B12, L-arabinose, and fermented bifidobacterium or fermented propionibacterium or fermented lactobacillus. The present invention further provides a method of preparing an enteral sustained-release sugar alcohol additive and an application thereof. In the present invention, by compounding xylitol, L-arabinose and vitamin B12, directional regulation of intestinal microorganisms can be achieved and high concentration synthesis of propionate in the intestine can be realized.
    Type: Application
    Filed: February 7, 2021
    Publication date: December 15, 2022
    Inventors: Shasha XIANG, Xuan ZHU, Lihua SHI, Kun YE, Mian LI