Patents by Inventor Miaosheng Li

Miaosheng Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-ionic acid-labile surfactants and methods of use
    Patent number: 9206226
    Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: December 8, 2015
    Assignee: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
  • NON-IONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
    Publication number: 20140302554
    Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.
    Type: Application
    Filed: June 23, 2014
    Publication date: October 9, 2014
    Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
  • Non-ionic acid-labile surfactants and methods of use
    Patent number: 8791251
    Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: July 29, 2014
    Assignee: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
  • Anionic acid-labile surfactants and methods of use
    Patent number: 8445223
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: May 21, 2013
    Assignee: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • Anionic acid-labile surfactants and methods of use
    Patent number: 8435756
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: May 7, 2013
    Assignee: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • NON-IONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
    Publication number: 20120309954
    Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.
    Type: Application
    Filed: June 1, 2012
    Publication date: December 6, 2012
    Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
  • ANIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
    Publication number: 20120264157
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.
    Type: Application
    Filed: June 25, 2012
    Publication date: October 18, 2012
    Applicant: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • ANIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
    Publication number: 20120264158
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.
    Type: Application
    Filed: June 25, 2012
    Publication date: October 18, 2012
    Applicant: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • Anionic acid-labile surfactants and methods of use
    Patent number: 8232423
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: July 31, 2012
    Assignee: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • ANIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
    Publication number: 20110282096
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilisation of proteins and other molecules in an aqueous environment.
    Type: Application
    Filed: August 1, 2011
    Publication date: November 17, 2011
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • ZWITTERIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
    Publication number: 20110250641
    Abstract: A compound of the formula: wherein R1 is independently selected from C1-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, Y? is an anion, m is an integer from 1 to 8 and n is an integer from 1 to 8 is described. Methods of making and using the compound are also described. The compound may comprise a zwitterionic acid-labile surfactant suitable for purification and identification techniques used in proteomics.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 13, 2011
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • Anionic acid-labile surfactants and methods of use
    Patent number: 8013179
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formulas: and wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also disclosed.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: September 6, 2011
    Assignee: Protea Biosciences, Inc.
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
  • Anionic acid-labile surfactants and methods of use
    Publication number: 20090292136
    Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8.
    Type: Application
    Filed: May 22, 2009
    Publication date: November 26, 2009
    Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li