Publication number: 20240043470
Abstract: The compounds of the present invention are represented by the following compounds having Formula I and Formula (I?): where the substituents R1, R2, R2?, R3, R4, R5, R?, R?, X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R?, R?, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.
Type:
Application
Filed:
September 25, 2023
Publication date:
February 8, 2024
Inventors:
Gang LIN, Carl NATHAN, Laura KIRKMAN, Wenhu ZHAN, Trevor MORGAN, Kenjiro SATO, Ryoma HARA, Masanori KAWASAKI, Toshihiro IMAEDA, Akinori TOITA, Rei OKAMOTO, Takafumi YUKAWA, Kazuyoshi ASO, Tzu-Tshin WONG, John D. GINN, Michael A. FOLEY
Patent number: 11834515
Abstract: The compounds of the present invention are represented by the following compounds having Formula I and Formula (I?): where the substituents R1, R2, R2?, R3, R4, R5, R?, R?, X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R?, R?, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.
Type:
Grant
Filed:
October 11, 2018
Date of Patent:
December 5, 2023
Assignees:
CORNELL UNIVERSITY, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE
Inventors:
Gang Lin, Carl Nathan, Laura Kirkman, Wenhu Zhan, Trevor Morgan, Kenjiro Sato, Ryoma Hara, Masanori Kawasaki, Toshihiro Imaeda, Akinori Toita, Rei Okamoto, Takafumi Yukawa, Kazuyoshi Aso, Tzu-Tshin Wong, John D. Ginn, Michael A. Foley
Patent number: 11732005
Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I?): where the substituents R, R1, R3, R4, R, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.
Type:
Grant
Filed:
November 8, 2021
Date of Patent:
August 22, 2023
Assignees:
CORNELL UNIVERSITY, TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE
Inventors:
Gang Lin, Carl Nathan, Wenhu Zhan, Trevor Morgan, Ryoma Hara, Toshihiro Imaeda, Rei Okamoto, Kenjiro Sato, Kazuyoshi Aso, Tzu-Tshin Wong, Michael A. Foley
Publication number: 20220324907
Abstract: The compounds of the present invention are represented by the following compounds having Formula I and Formula (I?): where the substituents R1, R2, R2?, R3, R4, R5, R?, R?, X, Y, and Z are as defined herein and where the substituents R1, R2, R3, R4, R5, R?, R?, X, Y, and Z are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.
Type:
Application
Filed:
October 11, 2018
Publication date:
October 13, 2022
Inventors:
Gang LIN, Carl NATHAN, Laura KIRKMAN, Wenhu ZHAN, Trevor MORGAN, Kenjiro SATO, Ryoma HARA, Masanori KAWASAKI, Toshihiro IMAEDA, Akinori TOITA, Rei OKAMOTO, Takafumi YUKAWA, Kazuyoshi ASO, Tzu-Tshin WONG, John D. GINN, Michael A. FOLEY
Publication number: 20220056073
Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I?): where the substituents R, R1, R3, R4, R, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.
Type:
Application
Filed:
November 8, 2021
Publication date:
February 24, 2022
Inventors:
Gang LIN, Carl NATHAN, Wenhu ZHAN, Trevor MORGAN, Ryoma HARA, Toshihiro IMAEDA, Rei OKAMOTO, Kenjiro SATO, Kazuyoshi ASO, Tzu-Tshin WONG, Michael A. FOLEY
Patent number: 11203613
Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I?): where the substituents R, R1, R3 R4, R?, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.
Type:
Grant
Filed:
October 11, 2018
Date of Patent:
December 21, 2021
Inventors:
Gang Lin, Carl Nathan, Wenhu Zhan, Trevor Morgan, Ryoma Hara, Toshihiro Imaeda, Rei Okamoto, Kenjiro Sato, Kazuyoshi Aso, Tzu-Tshin Wong, Michael A. Foley