Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: A high-voltage module, such as a traction battery, a traction inverter, or a DC/DC converter of a traction powertrain of an electrified vehicle (EV), includes an enclosure and a fuse box. An electronics assembly for performing electrical power operations is housed within the enclosure. The enclosure has a socket. The fuse box is removably insertable into the socket of the enclosure. The fuse box connects to the electronics assembly while the fuse box is inserted into the socket of the enclosure for the fuse box to provide a power distribution and fuse protection arrangement to the electronics assembly.

Abstract: A compact C-shaped scanner employs at least two sensors and has a mechanism to standardize or calibrate the sensors. The upper and lower elongated beams of the C-frame include a mid-beam sensor and an outer beam sensor. The scanner can monitor the entire width of a continuous sheet by advancing the scanner back and forth along a scanning distance that is only about half that of the sheet width thereby minimizing the required offsheet distance by an amount approaching half the width of the sheet being monitored. Standardization tiles consisting of references materials that are positioned laterally from the edges of the moving sheet allow for calibration of the sensors which operate either in the transmissive or reflective mode. Selected sheet properties or characteristics of the sheet material can be measured. The two sensors can operate in the transmissive or four sensors can operate in the reflective mode.

Abstract: A flatbed (10) is provided to which left and right-side skirts with wheel wells (14) may be coupled. Sets of skirts are provided with the wheel wells (14) in each set located in a respective predetermined position on the skirts to match a respective truck axle position, the respective predetermined position being different from set to set.

Abstract: Disclosed is a robot apparatus with a capable and highly maneuverable drive system incorporating two differential swerve drive pods. The robot apparatus further includes a claw mechanism for grasping an object, a passthrough mechanism for moving the object horizontally and a lift mechanism for moving the object vertically. The robot apparatus allows for rapid manipulation and movement of objects such as cones.

Abstract: In an aspect, a system for monitoring a battery system in-flight. The system includes at least a battery pack and a pack monitoring unit (PMU) communicatively connected with a battery pack. The battery pack includes a plurality of battery packs. The PMU may include at least a sensor and a controller. At least a sensor is configured to detect battery datum. A controller is communicatively connected with at least a sensor. A controller is configured to receive battery datum, detect a significant event as a function of battery datum, and transmit the significant event to a remote device.

Abstract: A monolithic break-seal includes a membrane that separates an outer ring from an inner ring. The inner ring is bonded to a vacuum cell and the outer ring is bonded to a vacuum interface. To protect against unintentional breakage of the membrane, a surface of the outer ring not bonded to the vacuum interface contacts the vacuum cell. An external vacuum system evacuates the vacuum cell through an aperture of the break-seal. Once a target vacuum level is reached for the vacuum cell, a cap is bonded to the inner ring, blocking the aperture and hermetically sealing the vacuum cell. The membrane is broken so that the hermetically sealed vacuum cell can be separated from the vacuum interface to which the outer ring remains bonded.

Abstract: A method for removing one or more objects or materials from a body lumen includes delivering a tube and an expandable device to the body lumen to a position proximal to the one or more objects or materials. The expandable device is positioned with a lumen of the tube, and the expandable device includes a lumen extending from a distal portion to a proximal portion. The method further includes proximally retracting the tube such that the expandable device remains in the position proximal to the one or more objects or materials, distally advancing the expandable device such that the distal portion of the expandable device at least partially surrounds the one or more objects or materials, at least partially closing a distal end of the expandable device, and moving the expandable device proximally to remove the expandable device and the one or more objects or materials from the lumen.

Abstract: The present disclosure provides a tissue debridement device and describes an example treatment for ANP using the tissue debridement device. The tissue debridement device has a sheath, a distal tip, and a plurality of rotating tines coupled to the distal tip and the sheath. The distal tip can be adjusted to be closer or further from the sheath to change a diameter of the rotating tines, thereby changing a cutting diameter of the tissue debridement device.

Abstract: One example of an internet protocol (IP) keyboard, video, mouse (KVM) device includes a universal serial bus, a display port, a network port, and a processor. The USB port is to be communicatively coupled to a host device. The display port is to be communicatively coupled to the host device. The network port is to be communicatively coupled to a network. The processor is communicatively coupled to the USB port, the display port, and the network port. The processor is to receive, via the display port, a multi-stream transport (MST) DisplayPort signal; demux the MST DisplayPort signal to provide a plurality of individual video streams; and output, via the network port, each individual video stream.

Abstract: A system for providing a solar harvesting building envelope is disclosed. The system includes a plurality of solar harvesting apparatus configured to be installed as or on a building envelope in a manner like that of traditional shingles or siding. The apparatus includes a frame having a photovoltaic end wall, and reflective base and side walls. A translucent, wedge-shaped body layer is positioned on the frame. A luminescent species film is positioned at and substantially parallel to a base of the wedge-shaped body layer, such that the luminescent species film is positioned at an angle relative to the photovoltaic end wall. Light incident on the wedge-shaped body layer is concentrated towards the photovoltaic end wall, such as through absorption and re-emission along with scattering by the luminescent species film and internal reflection by the wedge-shaped body layer and the reflective base and side walls of the frame.

Abstract: An aerosolizable material is provided. The aerosolizable material comprises at least one cannabinoid and at least one carrier constituent, wherein the material does no comprise a surface active constitute. Methods of making the aerosolizable material and articles comprising the aerosolizable material are also provided.

Abstract: An image presentation system for an amusement park includes a first display with an opening extending therethrough, wherein at least a portion of the first display is viewable from a viewing area, a movable arm, wherein the movable arm is positioned within the opening, a second display supported by the movable arm and offset from the first display, wherein the second display conceals the opening from the viewing area, and a controller configured to provide a first image via the first display and a second image via the second display such that the second image comprises an image effect that accounts for the offset and coordinates with the first image to present as though the first image and the second image are a single image displayed by the first display.

Abstract: Apparatus operative via executable software to quantify building metrics using artificial intelligence analysis of a design plan. A design plan is represented using multiple dynamic components. Each dynamic component may include a parameter changeable via the user interactive interface. The dynamic components may be arranged in a user interactive interface to form a first set of boundaries, including a respective length and area, and defining at least a portion of a first unit. AI is used to determine a longest path of egress and a supportable occupancy load that may be used to determine compliance with parameters of a given code. The AI may assess whether a building described in the design plans complies with a relevant code set forth by an authority having jurisdiction. Codes may include, for example, codes enforcing fire safety and the Americans with Disabilities Act.

Abstract: A cannulation device is adapted to gain access to the patient's common bile duct. In some instances, the cannulation device includes a first guidewire lumen extending through an elongate shaft and terminating at a first oblique guidewire port, and a second guidewire lumen extending through the elongate shaft and terminating at a second oblique guidewire port. In some instances, the cannulation device includes an inflatable balloon that is inflatable from a collapsed configuration to an expanded configuration in which the inflatable balloon is adapted to occlude the patient's pancreatic duct. In some instances, the cannulation device includes an expandable element that is expandable from a collapsed configuration in which the expandable element is disposed within the guidewire lumen and an extended configuration in which a portion of the expandable element extends distally from a guidewire port.

Abstract: A pulsed-laser applies short (e.g., less than 10 pico-seconds) pulses to modify quantum particle (e.g., alkali-metal and alkaline-earth-metal atoms) ultra-high vacuum (UHV) cells to bond, ablate, and/or chemically modify vacuum-facing surfaces of the cell. The pulses are generated outside the cell and are transmitted through a vacuum-boundary wall. In one example, one vacuum-boundary wall is first contact bonded to other vacuum boundary walls at a relatively low temperature (below 200° C.), sufficient to form a temporary hermetic seal. Pulsed laser bonding is used to reinforce the contact bonds, correcting defects and generally increasing the robustness of the seal. The pulses provide high peak power to ensure strong bonds, but low total heat so as to avoid heat damage to nearby cell components and to limit quantum-particle sorbtion to and into cell walls.

Abstract: The present disclosure provides compositions that enable sustained release of a small molecule tyrosine kinase inhibitor, such as axitinib from a bioerodible polyester polymer implant for the treatment of disease. The composition is especially suitable for treating ophthalmic indications, such as neovascular age related macular degeneration and diabetic macular edema, by intravitreal injection of the implant. The implant is designed to be pre-loaded into a small diameter needle and injected via self-sealing scleral needle penetration at the pars plana. Small molecule tyrosine kinase inhibitors may be released from the implants over a period of one week to three years.

Abstract: The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.

Abstract: In an aspect, a system for monitoring a battery system in-flight. The system includes at least a battery pack and a pack monitoring unit (PMU) communicatively connected with a battery pack. The battery pack includes a plurality of battery packs. The PMU may include at least a sensor and a controller. At least a sensor is configured to detect battery datum. A controller is communicatively connected with at least a sensor. A controller is configured to receive battery datum, detect a significant event as a function of battery datum, and transmit the significant event to a remote device.

Abstract: A machine direction (MD) position profile measurement of a moving sheet records the MD position of each of the cross direction (CD) measurements. A sheet monitoring system includes means for measuring the MD speed of the sheet of material; means for associating measured MD speed with time to generate time-associated MD speeds; means for recording the time-associated MD speeds; a first scanning sensor for measuring a first characteristic of the sheet material wherein the first scanning sensor is located at a first position along the MD and the first scanner sensor traverses back and forth along a CD; and means for associating first characteristic measurements with time to generate time-associated first characteristic measurements. Single and multiple scanning sensors can be employed. For multiple scanner systems where the scanners are synchronized, the technique enables recreation of the real zig-zag measurement path and same spot measurements.