Patents by Inventor Michael A. Klein
Michael A. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11976426Abstract: A soil processing machine, in particular a soil compactor, includes at least one drive roller and an electrohydraulic drive system for driving at least one drive roller. The drive system has a traction hydraulic circuit having at least one hydraulic motor and at least one hydraulic pump. The circuit includes a first line region between a first connection fitting of the at least one hydraulic pump and a first connection fitting of each hydraulic motor to drive the at least one drive roller in a first rotatable direction and a second line region between a second connection fitting of the at least one hydraulic pump and a second connection fitting of each hydraulic motor to drive the at least one drive roller in a second, opposite rotatable direction. A valve assembly is provided with each line region for selectively interrupting and releasing a fluid flow connection between the at least one hydraulic pump and at least one hydraulic motor.Type: GrantFiled: October 20, 2022Date of Patent: May 7, 2024Assignee: HAMM AGInventors: Thomas Klein, Stefan Braunschläger, Ronny Pieske, Michael Sperber, Josef Dagner
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Patent number: 11975737Abstract: This provides locations for mounting controllers and processing components that effectively employ the roof within a frame covered by a cowling so as to avoid exposure to weather and the environment. The roof is also employed to provide a sensor bar that extends across the vehicle width for a distance that does not interfere with normal vehicle function or generate potential overhangs, which can inadvertently engage objects or vehicles. The bar is sufficient in size and shape so as to allow mounting of a plurality of types of sensors on its top surface and/or recessed within front or rear edges. Such sensors can include visual light cameras for machine vison processes and/or LIDAR of various types and cooperage areas/fields of view—some of which can be recessed within a hollow region of the bar. Additional sensors can be mounted on the truck cab and/or chassis, including visual-light cameras and radars.Type: GrantFiled: October 26, 2021Date of Patent: May 7, 2024Assignee: Outrider Technologies, Inc.Inventors: Gary Michael Seminara, James Christopher McKenna, Michael Patrick Cutter, Jonathan Record, Dale Dee Rowley, Keith Massie, Alexander Fink, Critt Coburn, Gary Mckinney, Lawrence S. Klein
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Patent number: 11976284Abstract: A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal carbon source repressing the promoter, b) cultivating the cell line with a limited amount of a supplemental carbon source de-repressing the promoter to induce production of the POI at a transcription rate of at least 15% as compared to the native pGAP promoter, and c) producing and recovering the POI; and further an isolated regulatable promoter and a respective expression system.Type: GrantFiled: March 18, 2022Date of Patent: May 7, 2024Assignee: LONZA LTDInventors: Diethard Mattanovich, Brigitte Gasser, Michael Maurer, Roland Prielhofer, Joachim Klein, Jana Wenger
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Publication number: 20240145237Abstract: A method of applying a dielectric coating on a structure array of a component of an electrical device includes applying a first layer of a first dielectric material on a structure array with an atomic layer deposition (ALD) process. The structure array is formed on a substrate and has a plurality of features, each of the plurality of features having an aspect ratio of at least 1:1.Type: ApplicationFiled: October 31, 2023Publication date: May 2, 2024Inventors: Christopher Todd Ertsgaard, Adam Jay Ollanik, Todd Michael Klein, Amit Agrawal, Wenqi Zhu, Henri Joseph Lezec
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Publication number: 20240141503Abstract: A method of applying a dielectric coating on a structure array of a component of an electrical device includes applying a first layer of a first dielectric material on a structure array with an atomic layer deposition (ALD) process or a spin-on cladding process. The structure array has a plurality of features. The method may include applying a second layer of a second dielectric material on the first layer with an evaporation deposition process, a physical vapor deposition process (PVD), or a flux-controlled chemical vapor deposition (CVD) process. The first layer has a first thickness and the second layer has a second thickness that is greater than the first thickness.Type: ApplicationFiled: October 31, 2023Publication date: May 2, 2024Inventors: Christopher Todd Ertsgaard, Adam Jay Ollanik, Todd Michael Klein, John Snyder, Ryan Patrick Shea, Christopher Todd DeRose, Michael Ryan Gehl
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Publication number: 20240141044Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.Type: ApplicationFiled: July 6, 2023Publication date: May 2, 2024Inventors: Oliver AST, Marina BACAC, Sabine IMHOF-JUNG, Christiane NEUMANN, Christian KLEIN, Stefan KLOSTERMANN, Michael MOLHOJ, Joerg Thomas REGULA, Wolfgang SCHAEFER, Pablo UMANA
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Publication number: 20240130779Abstract: A tissue cutting device has an outer sleeve with a distal window and an inner cutting sleeve which moves past the window to cut tissue. The inner cutting sleeve has a lumen which may have a larger proximal diameter than distal diameter. A perimeter of the window may comprise a dielectric material. A distal edge of the inner sleeve may be displaced inwardly.Type: ApplicationFiled: October 26, 2023Publication date: April 25, 2024Applicant: MINERVA SURGICAL, INC.Inventors: Aaron Germain, Kyle Klein, Michael D. Walker, Benedek Orczy-Timko, Balazs Lesko
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Publication number: 20240132859Abstract: Provided herein modified dehalogenases have extended surface loop regions that provide a location for internal fusion insertions and modulate binding interaction and activation of environmentally-sensitive chemistries.Type: ApplicationFiled: May 4, 2023Publication date: April 25, 2024Inventors: Michael P. Killoran, Lance P. Encell, Thomas Kirkland, Thomas Machleidt, Rachel Friedman Ohana, Robin Hurst, Mark A. Klein, Karilyn Porter, Rahele Esmatpour, Debayan De Bakshi
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Publication number: 20240131886Abstract: A system and method for operation of an autonomous vehicle (AV) yard truck is provided. A processor facilitates autonomous movement of the AV yard truck, and connection to and disconnection from trailers. A plurality of sensors are interconnected with the processor that sense terrain/objects and assist in automatically connecting/disconnecting trailers. A server, interconnected, wirelessly with the processor, that tracks movement of the truck around and determines locations for trailer connection and disconnection. A door station unlatches/opens rear doors of the trailer when adjacent thereto, securing them in an opened position via clamps, etc. The system computes a height of the trailer, and/or if landing gear of the trailer is on the ground and interoperates with the fifth wheel to change height, and whether docking is safe, allowing a user to take manual control, and optimum charge time(s). Reversing sensors/safety, automated chocking, and intermodal container organization are also provided.Type: ApplicationFiled: July 23, 2023Publication date: April 25, 2024Inventors: Andrew F. Smith, Lawrence S. Klein, Stephen A. Langenderfer, Martin E. Sotola, Vikas Bahl, Mark H. Rosenblum, Peter James, Dale Dee Rowley, Matthew S. Johannes, Gary Michael Seminara, Jeremy M. Nett, Christopher T. Bate, Michael Patrick Cutter
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Patent number: 11965825Abstract: The present disclosure relates to an in-line compact measuring device, for example for optical measurements, comprising a housing having a process connection intended to be connected to a process vessel connection complementary to the process connection; at least one sensor assembly arranged in the housing; and a measuring circuit that is connected to the sensor assembly and is arranged in the housing. The in-line compact measuring device has at least one fluid line in thermally conductive contact with at least one housing wall of the housing, which fluid line can be connected to a cooling fluid supply arranged outside the housing.Type: GrantFiled: July 30, 2021Date of Patent: April 23, 2024Assignee: Endress+Hauser Conducta GmbH+Co. KGInventors: Hongshuo Domnick, Christian Cramer, Michael Wiederkehr, Moritz Klein, Joachim Mannhardt
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Publication number: 20240125816Abstract: A probe head with a cylindrical portion and an oblique truncated portion angled downward toward a high-powered electronic device under testing. The probe head has a proximal end comprising an oblique truncated cone portion angled relative to the longitudinal axis at an input angle and has an analog signal input. The probe head has a digital signal output provided on the distal end of the housing.Type: ApplicationFiled: October 13, 2023Publication date: April 18, 2024Inventors: Michael J Mende, Mark Heimann, Richard Booman, Philipp Palffy-Daun-Seiler, Michael Engels, Nadja Laeaeperi, Benno Jacobs, Michael D Stevens, Nicolas Frabasile, Peter Hildenhagen, Kai Klein, Jurij Weber, Iris Zimmermann, Juergen Trueller, Thomas Podrebersek, Michael Eube, Frank Pannes, Matthew M Mende
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Patent number: 11957138Abstract: The present invention includes a process for producing a protein product from plants and yeasts. The process comprises the steps of: a) providing a thin stillage or a thin stillage concentrate; b) separating a protein concentrate from the provided thin stillage from a) by means of solid-liquid separation; c) diluting the protein concentrate from b) with an aqueous process liquid to a dry substance content of at most 15 wt. %, tempering the diluted protein concentrate to a temperature of at least 60° C.Type: GrantFiled: April 9, 2020Date of Patent: April 16, 2024Assignee: VERBIO VEREINIGTE BIOENERGIE AGInventors: Anne Lamp, Julia Pohl, Fabian Bonk, Michael Schlimbach, Wolfram Klein, Oliver Lüdtke
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Publication number: 20240117428Abstract: The present disclosure provides nucleotide conjugates each configured to include a core attached to multiple nucleotide-arms, where the nucleotide-arms are modular and comprise (i) a core attachment moiety, (ii) a spacer, (iii) a linker, and (iv) a nucleotide unit. The nucleotide unit of each nucleotide-arm can bind a polymerase which is complexed with a nucleic acid template and nucleic acid primer. The nucleotide unit can bind the 3? end of the primer at a position that is opposite a complementary nucleotide in the template strand. Under suitable conditions, the nucleotide unit of the nucleotide conjugates binds the primer strand but does not undergo polymerase-catalyzed incorporation. The binding event can be detected, and the specific base of the nucleotide unit can be identified. The nucleotide conjugates described herein are useful for nucleic acid sequencing methods, particularly for massively parallel sequencing methods employed for next gen sequencing platforms.Type: ApplicationFiled: August 2, 2023Publication date: April 11, 2024Inventors: MICHAEL PREVITE, MARK AMBROSO, TYLER LOPEZ, MICHAEL KLEIN, VIRGINIA SAADE, MATTHEW KELLINGER
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Patent number: 11952421Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.Type: GrantFiled: October 8, 2015Date of Patent: April 9, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Minh Diem Vu, Klaus Strein, Oliver Ast, Tanja Fauti, Anne Freimoser-Grundschober, Ralf Hosse, Christian Klein, Ekkehard Moessner, Samuel Moser, Ramona Murr, Pablo Umana, Sabine Jung-Imhof, Stefan Klostermann, Michael Molhoj, Joerg Regula, Wolfgang Schaefer
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Patent number: 11949198Abstract: A molding assembly for establishing an electrical connection between an electrified planar element, which is formed with a peripheral electrical contact, and an electrical device includes a plastic frame element having an electrical conductor. The plastic frame element is adapted to be disposed along a peripheral portion of the electrified planar element that includes the peripheral contact. The plastic frame element extends between two ends. The electrical conductor extends between the two ends of the plastic frame element on a side facing the electrified planar element so that, during attachment of the plastic frame element to the peripheral portion, an electrical connection is automatically establishable between the electrical conductor and the peripheral contact.Type: GrantFiled: October 5, 2020Date of Patent: April 2, 2024Assignee: ELKAMET KUNSTSTOFFTECHNIK GMBHInventors: Thorsten Fries, Juergen Ruehl, Andreas Schoch, Igor Dorscht, Michael Klein
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Patent number: 11911387Abstract: The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.Type: GrantFiled: December 15, 2020Date of Patent: February 27, 2024Assignee: Boehringer Ingelheim International GmbHInventors: Thomas Klein, Andreas Daiber, Odd-Erik Johansen, Michael Mark, Sanjaykumar Patel, Hans-Juergen Woerle
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Patent number: 11914759Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.Type: GrantFiled: January 19, 2022Date of Patent: February 27, 2024Assignee: Microsoft Technology Licensing, LLC.Inventors: Andrew Jackson Klein, Cory Ryan Bramall, Kyle Mouritsen, Ethan Harris Arnowitz, Jeremy Bruce Kersey, Victor Jia, Justin Thomas Savino, Stephen Michael Lucas, Darren A. Bennett
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Patent number: 11911388Abstract: The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing metabolic diseases, particularly diabetes, in patients with insufficient glycemic control despite a therapy with an oral and/or a non-oral antidiabetic drug.Type: GrantFiled: February 11, 2021Date of Patent: February 27, 2024Assignee: Boehringer Ingelheim International GmbHInventors: Eva Ulrike Graefe-Mody, Thomas Klein, Michael Mark, Hans-Juergen Woerle
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Patent number: 11888188Abstract: A fuel cartridge includes an inlet manifold and a plurality of fuel beds containing a hydride material. A first end of each of the fuel beds is coupled to the inlet manifold to receive wet hydrogen via the inlet manifold. An outlet manifold is coupled to a second end of each of the fuel beds to receive dry hydrogen from the fuel beds. The fuel beds are laterally spaced from each other providing space for flow of coolant fluid therebetween. Valves may be included in the inlet and outlet manifolds.Type: GrantFiled: March 14, 2019Date of Patent: January 30, 2024Assignee: Honeywell International Inc.Inventors: Paul Bryant Koeneman, Jeffrey Michael Klein, Steven J. Eickhoff, Gustav Rustan
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Publication number: 20240019133Abstract: Example embodiment relate to an air conditioner. A fastening device fastens a compressor on a bottom of a housing via a mounting component. A clamping element is arranged within a guiding element. The guiding element is arranged in a recess of the bottom of the housing and has a smaller length than the recess. Two stop elements are each associated with a front side of the clamping element, an axial distance between the stop elements being variable in the unassembled state and being fixed in an assembled state.Type: ApplicationFiled: October 25, 2021Publication date: January 18, 2024Inventors: Michael KLEIN, Wolfgang MUSELMANN