Patents by Inventor Michael A. Lerman

Michael A. Lerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230366707
    Abstract: A system for structural health monitoring of a panel includes a panel of a composite laminate structure. The system further includes a plurality of sensors disposed on at least a surface of the panel each configured to measure at least an electrical datum associated with a portion of the panel. The system further includes a data acquisition system electrically coupled to the plurality of sensors and configured to receive the at least an electrical datum. The system further includes an alert system electrically coupled to at least the data acquisition system and configured to alert a user based on the at least an electrical datum.
    Type: Application
    Filed: May 12, 2023
    Publication date: November 16, 2023
    Inventors: Addis Tessema, John Perraut, McKevin Veloso, Paul Roehm, Jonathan M. Cabot, Michael Lerman, Scott Larson, Satya Immani
  • Publication number: 20220211281
    Abstract: A method, device, and system for evaluating a vessel of a patient, and in particular the hemodynamic impact of a stenosis within the vessel of a patient. Proximal and distal pressure measurements are made using first and second instrument while the first instrument is moved longitudinally through the vessel from a first position to a second position and the second instrument remains in a fixed longitudinal position within the vessel. A series of pressure ratio values are calculated, and a pressure ratio curve is generated. One or more stepped change in the pressure ratio curve are then identified and/or located using an Automatic Step Detection (ASD) process and/or algorithm.
    Type: Application
    Filed: March 23, 2022
    Publication date: July 7, 2022
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: WENGUANG LI, QIAN LI, JUSTIN MICHAEL LERMAN, DAVID BURGESS
  • Patent number: 11311196
    Abstract: A method, device, and system for evaluating a vessel of a patient, and in particular the hemodynamic impact of a stenosis within the vessel of a patient. Proximal and distal pressure measurements are made using first and second instrument while the first instrument is moved longitudinally through the vessel from a first position to a second position and the second instrument remains in a fixed longitudinal position within the vessel. A series of pressure ratio values are calculated, and a pressure ratio curve is generated. One or more stepped change in the pressure ratio curve are then identified and/or located using an Automatic Step Detection (ASD) process and/or algorithm.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: April 26, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Wenguang Li, Qian Li, Justin Michael Lerman, David Burgess
  • Publication number: 20190261867
    Abstract: A method, device, and system for evaluating a vessel of a patient, and in particular the hemodynamic impact of a stenosis within the vessel of a patient. Proximal and distal pressure measurements are made using first and second instrument while the first instrument is moved longitudinally through the vessel from a first position to a second position and the second instrument remains in a fixed longitudinal position within the vessel. A series of pressure ratio values are calculated, and a pressure ratio curve is generated. One or more stepped change in the pressure ratio curve are then identified and/or located using an Automatic Step Detection (ASD) process and/or algorithm.
    Type: Application
    Filed: February 22, 2019
    Publication date: August 29, 2019
    Applicant: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: WENGUANG LI, QIAN LI, JUSTIN MICHAEL LERMAN, DAVID BURGESS
  • Patent number: 9944951
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: April 17, 2018
    Assignees: Board of Regents, The University of Texas System, The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Patent number: 8386104
    Abstract: A system and method is provided for determining a mode of operation of a hybrid vehicle, obtaining torque data and speed data based on the mode of operation, and displaying component icons as well as a graphical representation of power flows. The graphical representation of power flows is displayed between pairs of the component icons. The component icons represent components of the hybrid vehicle including an engine, a battery, drive wheels, and an electric machine arrangement.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: February 26, 2013
    Assignee: Ford Global Technologies, LLC
    Inventors: Ming Lang Kuang, Ryan Skaff, Paul Stephen Bryan, Michael Lerman
  • Publication number: 20120108880
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Application
    Filed: January 9, 2012
    Publication date: May 3, 2012
    Inventors: Lin Ji, John Minna, Jack Roth, Michael Lerman
  • Publication number: 20120076851
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Application
    Filed: May 24, 2011
    Publication date: March 29, 2012
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Patent number: 7977468
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 12, 2011
    Assignees: Board of Regents of the University of Texas System, The United States of America as represented by the Department of Health and Human Services
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Patent number: 7902441
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: March 8, 2011
    Assignees: Board of Regents, The University of Texas, The United States of America as represented by the Department of Health and Human Services
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Publication number: 20100305795
    Abstract: A system and method is provided for determining a mode of operation of a hybrid vehicle, obtaining torque data and speed data based on the mode of operation, and displaying component icons as well as a graphical representation of power flows. The graphical representation of power flows is displayed between pairs of the component icons. The component icons represent components of the hybrid vehicle including an engine, a battery, drive wheels, and an electric machine arrangement.
    Type: Application
    Filed: March 22, 2010
    Publication date: December 2, 2010
    Applicant: FORD GLOBAL TECHNOLOGIES, LLC
    Inventors: Ming Lang Kuang, Ryan Skaff, Paul Stephen Bryan, Michael Lerman
  • Patent number: 7781413
    Abstract: The present invention identifies the semaphorin polypeptide SEMA3B as a tumor suppressor. This molecule can inhibit tumor growth and induce apoptosis of tumor cells when produced internally in a cancer cell via gene transfer, or when applied extracellularly. These observations permit new methods for treatment and diagnosis of cancer.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: August 24, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: John Minna, Yoshio Tomizawa, Yoshitaka Sekido, Michael Lerman
  • Publication number: 20090023207
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Application
    Filed: October 31, 2007
    Publication date: January 22, 2009
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Publication number: 20040016006
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 22, 2004
    Applicant: U.S. of America, represented by the Secretary, Department of Health and Human Services.
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Publication number: 20030166557
    Abstract: The present invention identifies the semaphorin polypeptide SEMA3B as a tumor suppressor. This molecule can inhibit tumor growth and induce apoptosis of tumor cells when produced internally in a cancer cell via gene transfer, or when applied extracellularly. These observations permit new methods for treatment and diagnosis of cancer.
    Type: Application
    Filed: October 31, 2002
    Publication date: September 4, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: John Minna, Yoshio Tomizawa, Yoshitaka Sekido, Michael Lerman
  • Publication number: 20020164715
    Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.
    Type: Application
    Filed: July 10, 2001
    Publication date: November 7, 2002
    Inventors: Lin Ji, John Dorrance Minna, Jack Roth, Michael Lerman
  • Patent number: 4912206
    Abstract: Four clones have been isolated from an adult human brain cDNA library using an oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromosome 21.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: March 27, 1990
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dmitry Y. Goldgaber, Michael Lerman, D. Carleton Gajdusek
  • Patent number: 4145461
    Abstract: A water dispersion comprising i) up to about 50% by weight of a water-dispersible low molecular weight polyester having a number average molecular weight in the range of about 850-2500 and preferably 1100-1800 and an acid value in the range of about 40-85 milligrams of KOH/gram of said polyester (millig/g) and preferably in the range of about 45-65 millig/g, which comprises: (1) a non-linear polyester backbone having an acid value in the range of about 5-15 millig/g and preferably about 8-12 millig/g comprising the reaction product of an aliphatic polyol, an aromatic dicarboxylic acid, and a monocarboxylic acid and (2) pendant moieties of a polycarboxylic acid having at least one free carboxylic acid group and at least one ester linkage to said backbone, ii) about 0.5% to 4% by weight, as based upon said polyester, of a chelated titanate, and iii) a fugitive base, is disclosed to provide a useful warp sizing composition for synthetic yarn fibers.
    Type: Grant
    Filed: January 20, 1978
    Date of Patent: March 20, 1979
    Assignee: Standard Oil Company (Indiana)
    Inventors: Michael A. Lerman, John C. Lark
  • Patent number: 4100119
    Abstract: In a water soluble enamel paint composition comprising a water soluble polyester resin, the incorporation of a rosin-ester resin, such as PENTALYN.RTM. 255, into the polyester resin improves the water resistance and drying time of the resulting enamel paint.
    Type: Grant
    Filed: October 20, 1975
    Date of Patent: July 11, 1978
    Assignee: Standard Oil Company (Indiana)
    Inventor: Michael A. Lerman