Patents by Inventor Michael A. Liebermann

Michael A. Liebermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monophenotypic xenograft of megakaryocytic lineage and origin
    Patent number: 5147798
    Abstract: A continuous cell line of megakaryocytic origin is disclosed. This novel continuous cell line has been established in athymic nude mice. The cells of the established cell line monophenotypic for megakaryocytes is characterized as having multilobed nuclei and granular cytoplasm and being reactive for Factor VIII antigen, glycoprotein IIB-IIIa complex antigen and platelet peroxidase. The established cell line of this invention generates in isolatable quantities platelet-like factor IV, FGF-like, .beta.-thromboglobulin-like and TGF-.beta.-like growth factors. Methods for cultivating the established cell line, in a nude animal and isolating and purifying the proteins are also disclosed.
    Type: Grant
    Filed: July 5, 1991
    Date of Patent: September 15, 1992
    Assignee: Children's Hospital Medical Center
    Inventors: Beatrice C. Lampkin, David P. Witte, Richard E. Harris, Michael A. Liebermann