Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A distribution station includes a mobile trailer, a pump on the mobile trailer, at least one manifold on the mobile trailer and fluidly connected with the pump, a plurality of reels on the mobile trailer, and at least one fluid storage tank extending under the reels. A plurality of hoses are connected with a different one of the reels. A plurality of valves on the mobile trailer are situated between the at least one manifold and a respective different one of the reels. A plurality of fluid level sensors are associated with a different one of the hoses, and a controller is configured to individually open and close the valves responsive to the fluid level sensors.

Abstract: A distribution station includes a mobile trailer, a pump on the mobile trailer, at least one manifold on the mobile trailer and fluidly connected with the pump, a plurality of reels on the mobile trailer, and at least one fluid storage tank extending under the reels. A plurality of hoses are connected with a different one of the reels. A plurality of valves on the mobile trailer are situated between the at least one manifold and a respective different one of the reels. A plurality of fluid level sensors are associated with a different one of the hoses, and a controller is configured to individually open and close the valves responsive to the fluid level sensors.

Abstract: A converter converts an existing bulk bag unloader to a bulk cargo receiver that eliminates the use of bulk bags. The converter enables the unloader to receive a continuous feed of bulk cargo without any interruptions such as those needed to unload emptied bulk bags and reload the unloader with full bulk bags.

Abstract: A long fiber extrusion apparatus applies a polymer melt to a length of fiber using a die and an extruder where the length of fiber is directed to the die through a glass tube. The transparency of the glass tube enables viewing of the fiber as it is directed through the glass tube to monitor for any difficulties or problems encountered by the fiber passing through the glass tube. The glass interior surface of the glass tube reduces friction between the fiber and the glass surface and thereby reduces abrasion of the fiber and dust produced from abrasion of the fiber inside the glass tube.

Abstract: A long fiber extrusion apparatus applies a polymer melt to a length of fiber using a die and an extruder where the length of fiber is directed to the die through a glass tube. The transparency of the glass tube enables viewing of the fiber as it is directed through the glass tube to monitor for any difficulties or problems encountered by the fiber passing through the glass tube. The glass interior surface of the glass tube reduces friction between the fiber and the glass surface and thereby reduces abrasion of the fiber and dust produced from abrasion of the fiber inside the glass tube.

Abstract: A bulk cargo blending hopper has a hollow interior volume that is selectively communicated with a source of vacuum pressure. A first conduit has a first end that is connected to the housing of the hopper and communicates with the interior volume of the housing of the hopper. An opposite second end of the first conduit is configured for communication with a source of bulk cargo that is separate from the hopper. A second conduit has a first end that is also connected to a portion of the housing of the hopper and communicates with the interior portion of the housing. A second end of the second conduit is also connected to a portion of the housing of the hopper and communicates with the interior volume of the housing of the hopper.

Abstract: A bulk cargo blending hopper has a hollow interior volume that is selectively communicated with a source of vacuum pressure. A first conduit has a first end that is connected to the housing of the hopper and communicates with the interior volume of the housing of the hopper. An opposite second end of the first conduit is configured for communication with a source of bulk cargo that is separate from the hopper. A second conduit has a first end that is also connected to a portion of the housing of the hopper and communicates with the interior portion of the housing. A second end of the second conduit is also connected to a portion of the housing of the hopper and communicates with the interior volume of the housing of the hopper.

Abstract: A converter converts an existing bulk bag unloader to a bulk cargo receiver that eliminates the use of bulk bags. The converter enables the unloader to receive a continuous feed of bulk cargo without any interruptions such as those needed to unload emptied bulk bags and reload the unloader with full bulk bags.

Abstract: A modular plastic extrusion apparatus has several component parts. The design of the integration of those parts into a modular extrusion system is unique. Said design allows for rapid assembly, testing, disassembly and placement into production of extruded plastics. This modular plastic extrusion apparatus has several components with replaceable counterparts that, after one product line of a particular color has been extruded by the apparatus, enable the component parts used to produce the particular color extrusion to be removed from the apparatus and replaced with their clean counterparts to continue producing an extrusion product line of a different color while the removed components are cleaned off line.

Abstract: A modular plastic extrusion apparatus has several component parts. The design of the integration of those parts into a modular extrusion system is unique. Said design allows for rapid assembly, testing, disassembly and placement into production of extruded plastics. This modular plastic extrusion apparatus has several components with replaceable counterparts that, after one product line of a particular color has been extruded by the apparatus, enable the component parts used to produce the particular color extrusion to be removed from the apparatus and replaced with their clean counterparts to continue producing an extrusion product line of a different color while the removed components are cleaned off line.

Abstract: Methods, apparatuses and systems are disclosed for supplying gas from a multi-container Bulk Specialty Gases Supply System wherein at least one process parameter is automatically monitored to prevent over-filling of at least a first and second container without operator intervention.

Abstract: A high pressure storage and delivery system having a fail-safe vacuum actuated valve is provided. In particular, through the innovative design of the vacuum actuated check valve, the system can accommodate up to three times the volume of product in similar size cylinders.

Abstract: Methods, apparatuses and systems are disclosed for supplying gas from a multi-container BSGS system wherein at least one process parameter is automatically monitored to prevent over-filling of at least a first and second container without operator intervention.

Abstract: This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such compounds to specific sites intracellularly. The invention specifically relates to methods of facilitating the entry of antiviral and antimicrobial drugs and other agents into phagocytic cells and for targeting such compounds to specific organelles within the cell. The invention specifically provides compositions of matter and pharmaceutical embodiments of such compositions comprising conjugates of such antimicrobial drugs and agents covalently linked to particulate carriers generally termed microparticles. In particular embodiments, the antimicrobial drug is covalently linked to a microparticle via a cleavable linker moiety that is non-specifically cleaved in a phagocytic cell.

Abstract: A high pressure storage and delivery system having a fail-safe vacuum actuated valve is provided. In particular, through the innovative design of the vacuum actuated check valve, the system can accommodate up to three times the volume of product in similar size cylinders.

Abstract: This invention provides novel methods and reagents for specifically delivering biologically active compounds to phagocytic mammalian cells. The invention also relates to specific uptake of such biologically active compounds by phagocytic cells and delivery of such compounds to specific sites intracellularly. The invention specifically relates to methods of facilitating the entry of antiviral and antimicrobial drugs and other agents into phagocytic cells and for targeting such compounds to specific organelles within the cell. The invention specifically provides compositions of matter and pharmaceutical embodiments of such compositions comprising conjugates of such antimicrobial drugs and agents covalently linked to particulate carriers generally termed microparticles. In particular embodiments, the antimicrobial drug is covalently linked to a microparticle via a cleavable linker moiety that is non-specifically cleaved in a phagocytic cell.

Abstract: A system for providing industrial gas to a use point in relatively small quantities that would otherwise require the use of high pressure gas cylinders, wherein industrial gas is generated from a feed, liquefied using refrigeration generated by a refrigeration system, and stored in a storage vessel prior to provision to the use point. The preferred refrigeration system is a pulse tube system powered by gas associated with the industrial gas generation system.

Abstract: A membrane system controller and control method for maximizing retentate product output and incorporating compressor load detection apparatus and process parameter instrumentation for feeding essential monitoring information to a control unit. Product output maximization is accomplished by increasing the membrane operating temperature during periods when compressor capacity is underutilized.