Abstract: The ?2-adrenergic receptor (?2AR) is a primary target in the treatment of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Since ?-agonist treatment of airway disease can have severe side effects, compounds that attenuate the side effects of ?-agonists have been identified via their ability to inhibit ?2AR interaction with ?-arrestins. These compounds are specific for the ?2AR and effectively protect against the desensitization observed with ?-agonist treatment in model cells and airway tissue. The present disclosure provides compounds and methods for treating airway disease, such as but not limited to COPD and/or asthma.

Abstract: A dropout recloser is capable of in accordance with its operating programming after a predetermined number of fault interrupting operations, e.g., 1, 2, 3 or more but typically 3, to drop out of a cutout and hang freely in a hinge contact of the cutout providing sectionalization with an observable visible gap. The recloser includes fault interrupting and reclosing components, a drop out mechanism and a controller. The drop out mechanism may include a bi-stable actuator to affect fault interrupting operation and dropout operation. The device may include motion limiting structures. The recloser may have a number of operating modes or sequences.

Abstract: A polymer masonry unit (PMU) and methods and systems for forming PMUs are presented. In embodiments, a PMU may be made from a PMU mixture of a polymer, a quarry byproduct, such as a limestone aggregate, and water. The PMU may be ambient-dried to become a brick unit. The proportions of the PMU mixture may include 1-10% polymer, 80-90% quarry byproduct, and 1-10% water. The process for making a brick using the PMU of embodiments may avoid a kiln-firing process, which is costly, creates waste, and consumes significant energy. Furthermore, the PMU mixture may be formulated to enable the PMU mixture to be extruded from an extruder, enabling a system for making bricks to take advantage of the extrusion method, which can be very efficient and cost-effective for making bricks, and which is currently not possible with existing techniques and systems.

Abstract: A wellhead assembly (100) comprises a wellhead apparatus (10) having a tubular body (16) defining an axial throughbore (18), a tubing hanger (12) for supporting downhole tubing (14) and associated downhole tools and equipment within the wellhead assembly (10), and more particularly orientating the tubing hanger (12) relative to a conductor (36). The wellhead apparatus (10) comprises a tubing hanger alignment arrangement (32) which in the illustrated apparatus (10) takes the form of a helical profile provided in an axial throughbore (18) of the tubular body (16). The tubing hanger alignment arrangement (32) is configured to engage an alignment arrangement (34) of the tubing hanger (12) so as to orient the tubing hanger (12) relative to the wellhead apparatus (10) as the tubing hanger (12) is run into the tubular body (16).

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof and solvates of any of the foregoing capable of inhibiting protein kinase A and/or its mutants, pharmaceutical compositions comprising at least one of the compounds, pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, processes for making the compounds, pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, and methods of using the same.

Abstract: A multispectral imaging device and system is provided. The multispectral imaging device includes a light emitting diode (LED) array including a plurality of LEDs configured to sequentially emit light towards a target object to be scanned, each of the LEDs being configured to emit a differing wavelength from one another; a scanning hood configured to house the LED array; a luminosity sensor configured to capture luminosity data of each light emitted by the plurality of LEDs and reflected from the target object; a printed circuit board (PCB) configured to provide electronic connections and mounting surfaces for the LED array and the luminosity sensor; a housing configured encase the PCB; and a trigger configured to initiate operation of the LED array.

Abstract: The invention provides methods of inhibiting the growth or metastasis of a cancer in a mammal by inhibiting a Ral GTPase in the mammal. The invention also provides small molecule inhibitors of Ral GTPases useful in the methods of the invention and pharmaceutical compositions containing the therapeutically effective compounds of the invention, and methods of using the same.

Abstract: Provided is a robot, including: a controller; a plurality of actuators mechanically coupled to an end-effector mount; a first set of end-effectors magnetically coupled to the end-effector mount; and a sensor adjacent an interface between at least some of the first set of end effectors and the end-effector mount, wherein: the end effectors are magnetically coupled to the end-effector mount with magnetic couplings that decouple in response to less than 200 Newtons of force being applied to distal portions of respective end effectors in a direction opposing movement of respective end effectors driven by at least some of the actuators, and the sensor is configured to output a signal indicative of a given end effector decoupling and indicate which end effector in the first decoupled.

Abstract: Systems and methods for generating a video of a user-defined virtual reality scene are disclosed. Exemplary implementations may: obtain a scene definition; obtain camera information for multiple virtual cameras to be used in generating a two-dimensional presentation of the virtual reality scene; execute a simulation of the virtual reality scene from the scene definition for at least a portion of the scene duration; obtain camera timing instructions specifying which of the virtual cameras should be used to generate the two-dimensional presentation of the virtual reality scene as a function of progress through the scene duration; generate the two-dimensional presentation of the virtual reality scene in accordance with the camera timing instructions and the camera information.

Abstract: A method comprises receiving a kernel used to convolve with an input tensor. For a first dimension of the kernel, a square block of values for each single dimensional vector of the kernel that includes all rotations of that single dimensional vector is generated. For each additional dimension of the kernel, group blocks of an immediately preceding dimension into sets of blocks, each set of blocks including blocks of the immediately preceding dimension that are aligned along a vector that is parallel to the axis of the dimension; and generate, for the additional dimension, one or more blocks of values, each block including all rotations of blocks within each of the sets of blocks of the immediately preceding dimension. The block of values corresponding to the last dimension in the additional dimensions of the kernel is output as the expanded kernel.

Abstract: A materialization configuration request is received via a programmatic interface from a client of a journal-based multi-data-store database. The request indicates a partitioning rule to be used to select, for respective writes indicated in committed transaction entries of a journal, the materialization node at which the writes are to be stored. A control plane component of the database verifies that a set of materialization nodes corresponding to the partitioning rule has been established, and initiates the propagation of writes from the journal to the materialization nodes by respective write appliers.

Abstract: This disclosure describes a system configured to present primary and secondary, tertiary, etc., virtual reality content to a user. Primary virtual reality content may be displayed to a user, and, responsive to the user turning his view away from the primary virtual reality content, a sensory cue is provided to the user that indicates to the user that his view is no longer directed toward the primary virtual reality content, and secondary, tertiary, etc., virtual reality content may be displayed to the user. Primary virtual reality content may resume when the user returns his view to the primary virtual reality content. Primary virtual reality content may be adjusted based on a user's interaction with the secondary, tertiary, etc., virtual reality content. Secondary, tertiary, etc., virtual reality content may be adjusted based on a user's progression through the primary virtual reality content, or interaction with the primary virtual reality content.

Abstract: A cubby unit includes a unit housing, a plurality of cubbies disposed within the unit housing, and an interface positioned along the unit housing. Each of the plurality of cubbies includes a cubby housing defining an internal compartment and a door coupled to the cubby housing. The door facilitates accessing the internal compartment of the cubby housing. The interface provides a cubby selection interface that facilitates manual assignment of a respective cubby to a respective order by an employee.

Abstract: A patient support apparatus supports a patient and includes a litter. A base is disposed below the litter. A lift mechanism is configured to move the litter and the base relative to one another between extended and collapsed positions. The lift mechanism includes first and second frame assemblies each including an outer frame member and an inner frame member arranged to move within the outer frame member. First and second rollers and first and second slide members are disposed between the outer and inner frame members. The first and second rollers are arranged to roll along at least one of the outer and inner frame members with a load exerted on the lift mechanism from the litter. The first and second slide members are arranged to slide along at least one of the outer and inner frame members with a load exerted on the lift mechanism from the base.

Abstract: An electronic device for temperature adjustable massage therapy. The device includes a temperature-controlled applied surface for delivering micropercussions to a user. In one example, the device is adapted to be adjusted to any number of different temperatures, and is further adapted to perform percussive therapy at any number of different amplitudes and/or frequencies. The user may engage a touch screen to adjust the temperature, amplitude, and/or frequency of the device.

Abstract: Systems and methods for securely delivering, transferring ownership, storing, accessing and receiving or returning an item from another are disclosed herein. In one embodiment, a system and method are provided to securely receive a variety of different sizes and types of packages at one or more locations, including but not limited to on or adjacent a recipient's property. In another embodiment, the system and method allow a user to receive, store and/or return an item without exposing the item to loss, damage, spoilage or other events that would impair the value of the items. Methods of utilizing the systems described herein are also disclosed.

Abstract: A system is disclosed for identifying a user based on the classification of user characteristic data. An identity verification system receives a request from a requesting target user for access to an operational context and characteristic data describing actions of the requesting target user. The identity verification system inputs the characteristic data to an identity confidence model to determine an identity confidence value describes a likelihood that an identity of the requesting target user matches an authenticating identity and determines a false match rate and false non-match rate, which represent a performance of the identity confidence model. The identity verification system determines a match probability for the requesting target user by adjusting the identity confidence value based on the determined false match rate and false non-match rate and grants the requesting target user access to the operational context if match probability is greater than the operational security threshold.

Abstract: The present disclosure discloses sanitary tissue product package(s) and/or arrays of sanitary tissue product packages comprising novel actual shoulder area(s) and/or novel actual shoulder area ratio(s). The packages of the present disclosure may comprise reveal(s) that overlap and show roll size (e.g., roll diameter) and/or abutting roll space and/or actual shoulder area.