Abstract: A fluid transfer assembly is described. The fluid transfer assembly includes a unitary junction having an upstream portion and a downstream portion, the unitary junction defining a plurality of curved fluid pathways between the upstream portion and the downstream portion. The assembly also includes at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways.

Abstract: A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.

Abstract: A fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough is provided. The fluid transport apparatus may include a conduit extending between a first terminus and a second terminus. The conduit may include platinum catalyzed silicone rubber having methyl and phenyl side groups. The conduit may have a storage modulus of 108 or less Pascals at ?75 degrees Celsius. At least one fitting may be connected to the first terminus. A fluid storage accessory may be engaged with the second terminus. A related flexible conduit, method of manufacturing a flexible conduit, and storage method are also provided.

Abstract: A fluid transport system is provided. The fluid transport system may include a vessel closure assembly including one or more conduits, a vessel, and a container. A conduit terminus may be engaged with the conduit and received in the vessel. The conduit terminus may include a body with a head portion and an engagement portion, wherein an aperture extends therethrough. The engagement portion may be configured to engage the conduit. The head portion may taper to a tip defining a first opening to the aperture having a hyperbolic paraboloid shape.

Abstract: Vessel closures having a variety of inserts for aseptically sealing vessels. The vessel closures have a body with one or more apertures, one or more inserts extending axially through the one or more apertures, and a cast seal surrounding the inserts. The cast seal is preferably east silicone. The vessel closures may have one or more anchors securing the inserts to the body of the vessel closure. Also disclosed are methods of manufacturing vessel closures and a method of using the vessel closures disclosed herein for circulating fluids into and out of a vessel while also having the ability to regulate the temperature of the pumped fluid.

Abstract: Detachable fluid transfer device accessories and fluid transfer assemblies are provided. The device accessories can include an upper extension defining a lower engagement surface; a lower extension defining an upwardly extending protrusion; a connector portion extending between the upper extension and the lower extension; and a resilient engagement member coupled to the lower engagement surface of the body. The upper extension, the lower extension, and the connector portion can collectively define a cavity configured to receive a tab assembly of a fluid transfer device, where the upwardly extending protrusion is configured to engage a housing of the fluid transfer device, and the resilient engagement member is configured to engage an upper surface of the tab assembly to retain the tab assembly in a fixed configuration relative to the housing.

Abstract: A fluid transport system is provided. The fluid transport system may include a vessel closure assembly including one or more conduits, a vessel, and a container. A conduit terminus may be engaged with the conduit and received in the vessel. The conduit terminus may include a body with a head portion and an engagement portion, wherein an aperture extends therethrough. The engagement portion may be configured to engage the conduit. The head portion may taper to a tip defining a first opening to the aperture having a contour that is non-planar.

Abstract: A fluid transport system is provided. The fluid transport system may include a vessel closure assembly including one or more conduits, a vessel, and a container. A conduit terminus may be engaged with the conduit and received in the vessel. The conduit terminus may include a body with a head portion and an engagement portion, wherein an aperture extends therethrough. The engagement portion may be configured to engage the conduit. The head portion may taper to a tip defining a first opening to the aperture having a contour that is non-planar.

Abstract: A fluid transfer device for transferring fluid into or out of a fluid vessel, such as a tank, and is particularly useful in transferring fluids with particulates or high viscosity in a substantially aseptic, hygienic, or sterile manner. The device has a body with an elongate passage extending through the body. The body has a proximal end and a distal end. A longitudinally displaceable shaft is disposed in and extends along the passage in the body. A plug sealing the passage is at a first location. A diaphragm sealing the passage is at a second location intermediate the plug and the distal end of the passage. The shaft extends through and is secured to the diaphragm. A fluid transfer opening is located in the passage between the diaphragm and the plug. Longitudinal displacement of the shaft causes the fluid transfer opening to be in fluid communication with a fluid vessel, the diaphragm stretching to accommodate the displacement of the shaft while maintaining an aseptic seal of the passage.

Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.

Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.

Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.

Abstract: Vessel closures having a variety of inserts for aseptically sealing vessels. The vessel closures have a body with one or more apertures, one or more inserts extending axially through the one or more apertures, and a cast seal surrounding the inserts. The cast seal is preferably east silicone. The vessel closures may have one or more anchors securing the inserts to the body of the vessel closure. Also disclosed are methods of manufacturing vessel closures and a method of using the vessel closures disclosed herein for circulating fluids into and out of a vessel while also having the ability to regulate the temperature of the pumped fluid.

Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.

Abstract: A fluid transfer device for transferring fluid into or out of a fluid vessel, such as a tank, and is particularly useful in transferring fluids with particulates or high viscosity in a substantially aseptic, hygienic, or sterile manner. The device has a body with an elongate passage extending through the body. The body has a proximal end and a distal end. A longitudinally displaceable shaft is disposed in and extends along the passage in the body. A plug sealing the passage is at a first location. A diaphragm sealing the passage is at a second location intermediate the plug and the distal end of the passage. The shaft extends through and is secured to the diaphragm. A fluid transfer opening is located in the passage between the diaphragm and the plug. Longitudinal displacement of the shaft causes the fluid transfer opening to be in fluid communication with a fluid vessel, the diaphragm stretching to accommodate the displacement of the shaft while maintaining an aseptic seal of the passage.

Abstract: A device is provided for transferring fluid into or out of a tank and is particularly useful in transferring fluid in a substantially aseptic, hygienic, or sterile manner. The device has a body with an elongate passage extending through the body. The body has a proximal end and a distal end. A longitudinally displaceable cannula is disposed in and extends along the passage in the body. A septum sealing the passage is at a first location; the septum being pierceable and self-sealing. A diaphragm sealing the passage is at a second location intermediate the septum and the distal end of the passage. The cannula extends through and is secured to the diaphragm and has a sharpened end disposed adjacent to or in the septum. Longitudinal displacement of the cannula causes its sharpened end to pierce and project through the septum, the diaphragm stretching to accommodate the displacement of the cannula while maintaining its aseptic seal of the passage.

Abstract: A fluid transfer device for transferring fluid into or out of a fluid vessel, such as a tank, and is particularly useful in transferring fluids with particulates or high viscosity in a substantially aseptic, hygienic, or sterile manner. The device has a body with an elongate passage extending through the body. The body has a proximal end and a distal end. A longitudinally displaceable shaft is disposed in and extends along the passage in the body. A plug sealing the passage is at a first location. A diaphragm sealing the passage is at a second location intermediate the plug and the distal end of the passage. The shaft extends through and is secured to the diaphragm. A fluid transfer opening is located in the passage between the diaphragm and the plug. Longitudinal displacement of the shaft causes the fluid transfer opening to be in fluid communication with a fluid vessel, the diaphragm stretching to accommodate the displacement of the shaft while maintaining an aseptic seal of the passage.

Abstract: A fluid transfer device for transferring fluid into or out of a fluid vessel, such as a tank, and is particularly useful in transferring fluids with particulates or high viscosity in a substantially aseptic, hygienic, or sterile manner. The device has a body with an elongate passage extending through the body. The body has a proximal end and a distal end. A longitudinally displaceable substantially hollow substantially hollow shaft is disposed in and extends along the passage in the body. A plug sealing the passage is at a first location. A diaphragm sealing the passage is at a second location intermediate the plug and the distal end of the passage. The shaft extends through and is secured to the diaphragm and has a fluid transfer opening between the diaphragm and the plug.