Patents by Inventor Michael Appel

Michael Appel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10758536
    Abstract: The present application discloses a method of treating a Varicella-Zoster Virus (VZV) infection in an individual in need thereof, including the step of administering to said individual an effective Varicella-Zoster Virus antiviral amount of a compound called N-methanocarbathymidine (N-MCT), which has a northern configuration with the structure as follows
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: September 1, 2020
    Assignee: L & J Bio Inc
    Inventors: Jennifer Moffat, Dongmei Liu, Wanda Coombs, Michael Appel, Aquilur Rahman
  • Publication number: 20190152004
    Abstract: The present disclosure shows a workpiece lock for an apparatus for handling and/or machining workpieces, which includes a robot for handling and/or machining the workpieces and a safety fence, wherein the work-piece lock has at least one closed position in which the workpiece lock closes an opening in the safety fence, wherein on moving a workpiece from the area within the safety fence to the area outside the safety fence and/or vice versa the workpiece lock has at least one open position in which it at least partly clears the opening in the safety fence. The present disclosure includes a safety function that prevents a movement of the robot into a safety area extending around the workpiece lock within the safety fence, when the lock is in the at least one open position.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 23, 2019
    Inventors: David HÄNSCHKE, Michael APPEL
  • Publication number: 20160324857
    Abstract: The present application discloses a method of treating a Varicella-Zoster Virus (VZV) infection in an individual in need thereof, including the step of administering to said individual an effective Varicella-Zoster Virus antiviral amount of a compound called N-methanocarbathymidine (N-MCT), which has a northern configuration with the structure as follows
    Type: Application
    Filed: May 3, 2016
    Publication date: November 10, 2016
    Inventors: Jennifer MOFFAT, DONGMEI LIU, WANDA COOMBS, MICHAEL APPEL, AQUILUR RAHMAN
  • Patent number: 6960274
    Abstract: An apparatus and method of manufacturing a wire mesh laminate includes wrapping a central core with multiple layers of mesh screen and a barrier layer having a higher melting point than the mesh screen to form a spool assembly. The spool assembly is then surrounded by an outer cover and is heated to sinter or fuse together the layers of mesh screen.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: November 1, 2005
    Assignee: Weatherford/Lamb, Inc.
    Inventors: John Bewlay, Thomas Steinke, Michael Appel
  • Publication number: 20050152897
    Abstract: Methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipeint are disclosed. The methods involve administering to a subject: 1) an allogeneic or xenogeneic cell which expresses donor antigens and which has a ligand on the cell surface which interacts with a receptor on the surface of a recipient T cell which mediates contact-dependent helper effector function; and 2) an antagonist of the receptor which inhibits interaction of the ligand with the receptor. In a preferred embodiment, the allogeneic or xenogeneic cell is a B cell, preferably a resting B cell, and the molecule on the surface of the T cell which mediates contact-dependent helper effector function is gp39. A preferred gp39 antagonist is an anti-gp39 antibody. The allogeneic or xenogeneic cell and the gp39 antagonist are typically administered to a transplant recipient prior to transplantation of the tissue or organ.
    Type: Application
    Filed: October 7, 2004
    Publication date: July 14, 2005
    Applicants: Trustees of Dartmouth College, University of Massachusetts Medical Center
    Inventors: Randolph Noelle, Fiona Durie, David Parker, Michael Appel, Nancy Phillips, John Mordes, Dale Grenier, Aldo Rossini
  • Patent number: 6761821
    Abstract: A centrifuge screen clamp comprises a body and a screen retaining portion connected to the body. The screen retaining portion comprises a pressure fitting surface and a clamp interface member engaging surface. In one embodiment, the pressure fitting surface is a substantially planar surface disposable on a screen portion of a centrifuge screen and the clamp interface member engaging surface is disposable on a clamp interface member disposed on the screen. The clamp interface member engaging surface operates to apply a counteractive force against the clamp interface member, which counteractive force is substantially coplanar with an inertial sliding tendency direction of the screen during rotation.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: July 13, 2004
    Assignee: Weatherford/Lamb, Inc.
    Inventors: Michael Appel, Ross van Someren, Richard Kalar
  • Publication number: 20040055947
    Abstract: A centrifuge screen clamp comprises a body and a screen retaining portion connected to the body. The screen retaining portion comprises a pressure fitting surface and a clamp interface member engaging surface. In one embodiment, the pressure fitting surface is a substantially planar surface disposable on a screen portion of a centrifuge screen and the clamp interface member engaging surface is disposable on a clamp interface member disposed on the screen. The clamp interface member engaging surface operates to apply a counteractive force against the clamp interface member, which counteractive force is substantially coplanar with an inertial sliding tendency direction of the screen during rotation.
    Type: Application
    Filed: September 23, 2002
    Publication date: March 25, 2004
    Inventors: Michael Appel, Ross Van Someren, Richard Kalar
  • Publication number: 20030029909
    Abstract: An apparatus and method of manufacturing a wire mesh laminate includes wrapping a central core with multiple layers of mesh screen and a barrier layer having a higher melting point than the mesh screen to form a spool assembly. The spool assembly is then surrounded by an outer cover and is heated to sinter or fuse together the layers of mesh screen.
    Type: Application
    Filed: August 5, 2002
    Publication date: February 13, 2003
    Inventors: John Bewlay, Thomas Steinke, Michael Appel