Patents by Inventor Michael B. Brenner

Michael B. Brenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human .gamma., .delta.T cell antigen receptor polypeptides and nucleic acids
    Patent number: 5185250
    Abstract: The present invention is directed to purified polypeptides comprising the .gamma. T cell antigen receptor (TCR) polypeptide, the .delta. TCR polypeptide, a .gamma., .delta. TCR complex, or a fragment thereof containing an epitope. The invention also relates to nucleic acid sequences encoding such polypeptides, and subsequences thereof. In specific embodiments, the invention relates to nucleic acid sequences comprising variable, diversity, joining, or constant regions of the .delta. TCR gene sequence. The invention also relates to monoclonal antibodies specifically reactive with an epitope of the gamma or delta TCR polypeptides. In specific embodiments, these antibodies are reactive with the delta constant region, the delta variable region, or gamma constant region. Such antibodies can be identified by detecting co-modulation of the CD3 antigen. In another embodiment, the invention relates to compositions comprising substantially purified cells which express both a .gamma., .delta. TCR and the CD4 antigen.
    Type: Grant
    Filed: January 13, 1989
    Date of Patent: February 9, 1993
    Assignees: T Cell Sciences, Inc., Dana Farber Cancer Institute, President & Fellows of Harvard College
    Inventors: Michael B. Brenner, Jonathan Seidman, Jack L. Strominger, Stephen H. Ip, Michael S. Krangel, Hamid Band
  • Nucleic acids encoding the delta chain of the T cell antigen receptor
    Patent number: 5024940
    Abstract: The present invention provides purified polypeptides which comprises at least a portion of a a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide, a .gamma..delta.T cell receptor complex or a .gamma..delta.T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.Additonally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: June 18, 1991
    Assignees: T Cell Sciences, Inc., Dana-Farber Cancer Institute, President & Fellows of Harvard College
    Inventors: Michael B. Brenner, Jack L. Strominger, Jonathan Seidman, Stephen H. Ip, Michael S. Krangel