Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A laminated light-polarizing composite lens is efficiently produced by bonding a pre-formed polarized sheet to the front convex surface of a molded polycarbonate lens in an autoclave. Excellent optical properties are obtained by the replication from a polished glass surface to the front surface of the lens. The outer surface layer of the finished lens is isotropic and thus does not produce unwanted birefringence effects. The method is especially well suited for the production of optically corrected decentered polycarbonate lenses. The process is simple and easily changed to produce lenses with different base curves and colors.

Abstract: A transparent polarized plastic laminate is provided which includes:(a) a first plastic layer;(b) a second layer comprising a polyurethane polymer;(c) a third layer comprising a sandwich of a stretched and dyed polyvinyl alcohol film between two layers of cellulose triacetate or acrylic;(d) a fourth layer comprising a polyurethane polymer; and(e) a fifth plastic layer.