Abstract: A bioactive agent delivery device having a plurality of reservoirs wherein each reservoir houses a solvent provides a means for separable and segregated delivery of bioactive agent(s) to a patient. The device can include a plurality of absorbent materials wherein each absorbent material is pretreated with a bioactive agent and a delivery mechanism operable to deliver to any of the plurality of absorbent materials a controlled portion of solvent from any of a plurality of reservoirs. A diffusion layer interposed between the absorbent materials and an epidermis transfers the bioactive agent from the absorbent materials to the epidermis for delivery of the bioactive agent.

Abstract: Pharmaceutical drugs and formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of an anti-fungal drug to at least one body surface, such as a nail, are described. Also described are pharmaceutical formulations suitable for iontophoresis comprising terbinafine and methods for administering terbinafine to a body surface via iontophoresis. When the drug source is introduced into the nail using a mask, terbinafine concentrations in peripheral areas of nail following iontophoretic treatment are less than drug concentrations directly under the mask. Further, differences in delivered drug concentrations is effectuated by creating drug delivery gradients. Drug can be delivered to dissimilar tissues based on different transfer efficiencies exhibited by the dissimilar tissues, resulting in higher percentage delivery in one tissue vs. another tissue.

Abstract: An applicator for a device for electrokinetic delivery of medicament to a treatment site includes an applicator head having an active electrode, a matrix, and a medicament or a medicament and an electrically conductive carrier, carried by the matrix in electrical contact with the electrode. The cartridge includes a plurality of raised projections allowing the matrix and head to be ultrasonically welded one to the other. The electrode opens through a face of the head remote from the matrix for connection with an electrical connector carried by the device. A lid overlies the matrix and is releasably attached to a margin of the head. The lid includes layers of different materials with one of the layers formed of a metallic material having a discontinued interface with the lid and a tab carried by the lid.