Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), particularly the spike protein S1 of SARS-CoV-2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by infection of SARS-CoV-2 or for providing prophylaxis to a subject at risk of infection of SARS-CoV-2.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of the COVID-19 nucleocapsid protein (N-protein). The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by the COVID-19 nucleocapsid protein (N-protein), such as infection of COVID-19 or for providing prophylaxis to a subject at risk of infection of COVID-19.

Abstract: A screen structure comprises at least one support element comprising a bistable extendable member; a panel element attached to the at least one support element, wherein the at least one support element and the panel element are configured to be rollable about a first longitudinal axis, to provide for extension and retraction thereof along a direction generally perpendicular to the first longitudinal axis; a handle element for extending and retracting the at least one support element and the panel element upon application of a force to the handle element, wherein when the at least one support element and the panel element are substantially fully retracted, the handle element is arrangeable in one or more first positions and in a parked position; and at least one guide element comprising a curved or angled portion which the handle element is configured to bear against and move relative to, to guide the handle element from the one or more first positions to the parked position.

Abstract: The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.

Abstract: A method of processing enhanced biosolids from a wastewater treatment plant to produce an output mixture. The method includes providing one or more volumes of an input mixture that has an input mixture viscosity. The input mixture includes the enhanced biosolids, which have been subjected to shear forces and mixed in a mixing vessel. The enhanced biosolids are partially hydrolyzed biosolids with an input solids content between 4% and 16% by weight of the input mixture. The input mixture also includes sufficient process liquid to result in the output mixture having an output solids content between 3% and 13% by weight of the output mixture. The input mixture is stored in a storage vessel in which the input mixture is subjected to anaerobic conditions and hydrolysis over a predetermined tie period, to form the output mixture having an output mixture viscosity that is less than the input mixture viscosity.

Abstract: A method of processing enhanced biosolids from a wastewater treatment plant to produce an output mixture. The method includes providing one or more volumes of an input mixture that has an input mixture viscosity. The input mixture includes the enhanced biosolids, which have been subjected to shear forces and mixed in a mixing vessel. The enhanced biosolids are partially hydrolyzed biosolids with an input solids content between 4% and 16% by weight of the input mixture. The input mixture also includes sufficient process liquid to result in the output mixture having an output solids content between 3% and 13% by weight of the output mixture. The input mixture is stored in a storage vessel in which the input mixture is subjected to anaerobic conditions and hydrolysis over a predetermined tie period, to form the output mixture having an output mixture viscosity that is less than the input mixture viscosity.

Abstract: Rolling bearing comprising an inner ring, rolling elements and an outer ring. According to one aspect of the invention the inner ring is produced by M62 steel powder metallurgical technique whilst the outer ring is a conventional stool ring. According to another aspect a rolling bearing having at least one component produced by powder metallurgy technique is in a actively lubricated condition.

Abstract: Method for the production of a part of a rolling bearing, such as a ring for a ball bearing. The starting material used is a grade of steel containing 0.90 1.00% C; at most 0.15% Si; 0.25-0.45% Mn; at most 0.0015% P; at most 0.010% S; 1.30-1.50% Cr; at most 0.15% Ni; 0.20-0.23% Mo; at most 0.20-0.23% Cu; at most 20 ppm Ti; at most 8 ppm O. Before subjecting this grade of steel to a quenching and tempering treatment, the shaped item is subjected to plastic deformation in the hot or cold state. The mechanical properties and in particular the anticipated life under severe stress improve as a result.

Abstract: Method for the production of a part of a rolling bearing, such as a ring for a ball bearing. The starting material used is a grade of steel containing 0.90 1.00% C; at most 0.15% Si; 0.25-0.45% Mn; at most 0.0015% P; at most 0.010% S; 1.30-1.50% Cr; at most 0.15% Ni; 0.20-0.23% Mo; at most 0.20-0.23% Cu; at most 20 ppm Ti; at most 8 ppm O. Before subjecting this grade of steel to a quenching and tempering treatment, the shaped item is subjected to plastic deformation in the hot or cold state. The mechanical properties and in particular the anticipated life under severe stress improve as a result.

Abstract: Rolling bearing comprising an inner ring, rolling elements and an outer ring. According to one aspect of the invention the inner ring is produced by M62 steel powder metallurgical technique whilst the outer ring is a conventional stool ring. According to another aspect a rolling bearing having at least one component produced by powder metallurgy technique is in a actively lubricated condition.

Abstract: A method for finishing the surface of a rolling contact component, such as a bearing roller element, a bearing ring or a traction drive rolling element, comprises the steps of: carrying out a cutting operation on the surface, subsequently calendering or burnishing the surface by means of a ball comprising a material harder than the bearing component material whereby the maximum calendering or burnishing pressure exerted on the surface is less than 7 Gpa.

Abstract: Rolling structure steel, comprising: 0.90-100% by wt. C; 0.95-1.05% by wt Si; 0.25-0.45% by wt Mn; 0.015% by wt. S max.; 0.025% by wt. P max.; 1.30-1.50% by wt. Cr, and 0.17-0.20% by wt. Mo. Preferably this steel is produced by austenising at 860+20° C., quenched in oil and tempered at 240+20° C. In this way steel is obtained having a high rolling contact fatigue strength and dimensional stability at elevated temperature operating conditions.

Abstract: A method for producing a rolling bearing component, in which, before ustenizing, the steel is subjected to cold deformation and quenching is such that the bainitic structure is obtained; and a rolling bearing component produced by the method, such as a rolling bearing ring from 1C to 1,5Cr type series steel, in which at least the surface of the rolling bearing component has a bainitic structure and the service life of the bainitic structure is considerably increased over a component not subjected to cold rolling.