Abstract: The present invention pertains to a treatment of cancer, particularly prostate cancer, by blocking the large conductance, Ca2+-activated potassium channel KCNMA1 Embodiments of the invention include methods of detecting the level of expression of KCNMA1, methods for treating patients with prostate cancer, and methods of discovering drugs for treating cancer.

Abstract: A consolidated plan splitting methodology sends distribution orders to a distribution execution system and planned production to a manufacturing execution system. Instructions from the planning system involving only movements of inventory within the distribution s system (e.g., warehouse to warehouse transfers) are passed directly to the distribution execution system. Instructions from the planning system involving movements of inventory where either the source or destination is in the manufacturing system causes a splitter located between the planning system and the distribution and manufacturing execution systems to carry out a decisional process wherein the movement of inventory is broken down into a selected number of distinct intermediate legs. Control of inventory balances is passed between the distribution and manufacturing execution systems as appropriate as the inventory moves from one execution system to another.

Abstract: A process for preparing salts of mono-esters of sulfosuccinic acid in which maleic acid, fumaric acid or maleic anhydride, especially maleic anhydride, is reacted with a fatty alcohol, an alkoxylated fatty alcohol or a fatty acid alkanolamide; and the butenedioic acid half ester so obtained is reacted with a finely powdered crystalline sulfite of an alkali or alkaline earth metal, by mechanically mixing and butenedioic acid half ester with said sulfite in the absence of water other than that present as water of crystallization in the crystalline sulfite, to yield the desired salt of a mono-ester of sulfosuccinic acid in a solid granular form.