Patents by Inventor Michael Boyce-Jacino

Michael Boyce-Jacino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS
    Publication number: 20090305273
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macro-molecules using such devices.
    Type: Application
    Filed: July 19, 2007
    Publication date: December 10, 2009
    Applicant: BIONANOMATRIX, INC.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • METHODS OF MACROMOLECULAR ANALYSIS USING NANOCHANNEL ARRAYS
    Publication number: 20080242556
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 2, 2008
    Applicant: BIONANOMATRIX, LLC
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • De novo or “universal” sequencing array
    Patent number: 6946249
    Abstract: The present invention describes a novel nucleic acid sequencing reagent which consists of a capture moiety, a spacer region and a sequence specific hybridizing region of 4-8 bases. The nucleic acid sequencing reagent of the present invention can also contain an attachment moiety. The nucleic acid sequencing reagent can be arranged into a nested array. This array configuration can then be used to sequence a given template without prior knowledge (de novo) of the wild type or expected sequence in conjunction with primer extension in the presence of a labeled chain terminating nucleotide.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 20, 2005
    Assignee: Beckman Coulter, Inc.
    Inventors: Steven R. Head, Philip Goelet, Jonathan Karn, Michael Boyce-Jacino
  • De novo or universal sequencing array
    Publication number: 20020146704
    Abstract: The present invention describes a novel nucleic acid sequencing reagent which consists of a capture moiety, a spacer region and a sequence specific hybridizing region of 4-8 bases. The nucleic acid sequencing reagent of the present invention can also contain an attachment moiety. The nucleic acid sequencing reagent can be arranged into a nested array. This array configuration can then be used to sequence a given template without prior knowledge (de novo) of the wild type or expected sequence in conjunction with primer extension in the presence of a labeled chain terminating nucleotide.
    Type: Application
    Filed: June 29, 2001
    Publication date: October 10, 2002
    Inventors: Steven R. Head, Philip Goelet, Jonathan Karn, Michael Boyce-Jacino
  • De novo or “universal” sequencing array
    Patent number: 6337188
    Abstract: The present invention describes a novel nucleic acid sequencing reagent which consists of a capture moiety, a spacer region and a sequence specific hybridizing region of 4-8 bases. The nucleic acid sequencing reagent of the present invention can also contain an attachment moiety. The nucleic acid sequencing reagent can be arranged into a nested array. This array configuration can then be used to sequence a given template without prior knowledge (de novo) of the wild type or expected sequence in conjunction with primer extension in the presence of a labeled chain terminating nucleotide.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: January 8, 2002
    Assignee: Orchid BioSciences, Inc.
    Inventors: Steven R. Head, Philip Goelet, Jonathan Karn, Michael Boyce-Jacino
  • De novo or “universal” sequencing array
    Patent number: 6322968
    Abstract: The present invention describes a novel nucleic acid sequencing reagent which consists of a capture moiety, a spacer region and a sequence specific hybridizing region of 4-8 bases. The nucleic acid sequencing reagent of the present invention can also contain an attachment moiety. The nucleic acid sequencing reagent can be arranged into a nested array. This array configuration can then be used to sequence a given template without prior knowledge (de novo) of the wild type or expected sequence in conjunction with primer extension in the presence of a labeled chain terminating nucleotide.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: November 27, 2001
    Assignee: Orchid BioSciences, Inc.
    Inventors: Steven R. Head, Philip Goelet, Jonathan Karn, Michael Boyce-Jacino
  • Gene pen devices for array printing
    Patent number: 6235473
    Abstract: The invention concerns an apparatus for printing arrays of molecules and methods for printing these arrays. More particularly, the invention relates to a gene pen apparatus that may be used for delivering arrays of oligonucleotides on solid supports from a multiplicity of reagent reservoirs through flow controlling means. The flow controlling means may for example, be either a pin valve means or a wicking means.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: May 22, 2001
    Assignee: Orchid BioSciences, Inc.
    Inventors: Mitchell Friedman, Yu-Hui Rogers, Michael Boyce-Jacino