Abstract: Disclosed are compounds for medical uses, for example, compounds of formula Ia, wherein A1, A2, A3, A4, A5, A6, A7, R6, R7 and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

Abstract: Methods and system for waste collection and transport systems are provided. Systems of the present disclosure comprise at least one of a loading station and a chute providing a point of ingress for materials into a larger system. A plurality of vertical risers or branches are provided. The system and related methods generate a priority order of emptying loading stations based at least in part on loading stations that are provided on the same riser.

Abstract: Disclosed are compounds for medical uses, for example, compounds of formula (Ia), wherein A1, A2, A3, A4, A5, A6, A7, R6, R7 and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

Abstract: Digital content distribution methods, systems and devices are provided. The digital content distribution utilizes a content distribution server for providing a user device access to digital content. In certain embodiments, the content distribution server: (a) receives a check-out request from a user device via a content access device; (b) provides metainfo to the user device via the content access device; (c) receives an open content command comprising an identifier of the digital content and an identifier for a user from the user device; (d) determines from the open content command whether the user device is authorized to view the digital content; and (e) provides a license response to the user device based on the user device being authorized to view the digital content, the license response comprising a license and the digital content.

Abstract: A color correction device includes a computation engine including a processor and a memory coupled to the processor. The computation engine is configured to receive reference color data. A software application stored in the memory and configured to compute adjustment values needed to achieve the reference color data from a target color. An output configured to output color corrected signals to light emitting diodes (LEDs) to achieve a reference color associated with the reference color data from the target color of the LEDs.

Abstract: A lighting device includes a substrate, an electrical circuit operably coupled to the substrate, a connector block operably coupled to the substrate and in electrical communication with the electrical circuit, and a casing disposed over the substrate, the electrical circuit, and the connector block. A portion of the casing defines a contact surface. The contact surface and a portion of the substrate define a cavity therebetween. A portion of the contact surface of the casing abuts a corresponding portion of the connector block to provide mechanical support to a joint formed between a portion of connector block and a portion of the substrate.

Abstract: Disclosed are compounds for medical uses, for example, compounds of formula (Ia), wherein A1, A2, A3, A4, A5, A6, A7, R6, R7 and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition, for example, cancer.

Abstract: A junction box includes a bottom portion including a first end portion and a second end portion and a top portion configured to mate with the bottom portion. The top and bottom portions form a first opening to receive a first cable at the first end portion and form a second opening to receive a second cable at the second end portion. Interchangeable connection blocks are included for receiving wires of different gauges to make connections between the first cable and the second cable. A connection block receiving-feature is formed in the bottom portion to secure the connection blocks.

Abstract: A door locking system for opening and closing a door lock in a door. The door locking system includes a first door handle unit with a first door handle and a second door handle unit with a second door handle. The first door handle and the second door handle are pivotable about a common pivot axis. The door locking system comprises a coupling device with an axially aligned polygonal pin which has two pin pieces. The respective pin piece is connected to the respective door handle in a pivotably fixed manner.

Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: Medical devices, methods and kits are described. An exemplary medical device comprises a catheter that has a catheter wall and defines a catheter lumen, a bend, and a coil disposed distal to the bend. The catheter defines one or more apertures that extend through the catheter wall and are in communication with the catheter lumen.

Abstract: A lighting fixture includes a first compartment including a light sealed air plenum and a first lighting source arranged in the plenum to irradiate passing air through the plenum to destroy pathogens. A second compartment is configured to be external to the first compartment. A second lighting source is arranged in the second compartment to illuminate an area adjacent to the second compartment.

Abstract: A lighting fixture includes a first compartment including a light sealed air plenum and a first lighting source arranged in the plenum to irradiate passing air through the plenum to destroy pathogens. A second compartment is configured to be external to the first compartment. A second lighting source is arranged in the second compartment to illuminate an area adjacent to the second compartment.

Abstract: A pipeline pig includes a pair of axially spaced apart sleeve housings containing an axially extending central shaft so as to define therebetween a fluid flow path that extends axially through the pipeline pig. A circumferential brush is rotatably mounted on the central shaft, and exposed between the pair of sleeve housings. A turbine wheel is disposed in the flow path and attached to the circumferential brush. Vanes of the turbine wheel are configured such that axial fluid flow through the fluid flow path impinging on the vanes drives rotation of the turbine wheel and hence rotation of the attached circumferential brush about the central shaft. A scraper disc for a pipeline pig includes a body formed from a resilient material, and an insert formed from a wear-resistant material. The insert is incorporated into the body and defines one or more edges coinciding with the outer circumference of the body.

Abstract: A junction box includes a bottom portion including a first end portion and a second end portion and a top portion configured to mate with the bottom portion. The top and bottom portions form a first opening to receive a first cable at the first end portion and form a second opening to receive a second cable at the second end portion. Interchangeable connection blocks are included for receiving wires of different gauges to make connections between the first cable and the second cable. A connection block receiving-feature is formed in the bottom portion to secure the connection blocks.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: The present disclosure provides systems, apparatuses, and methods for monitoring building efficiency by a heating, ventilation, and air conditioning (HVAC) system. In an aspect, an HVAC unit including a memory and a processor coupled with the memory is disclosed. The processor may be configured to establish a current building efficiency state value of a current run cycle of the HVAC system. The processor may also be configured to determine an building efficiency state deviation value based on a difference between an average building efficiency state value of a set of previous building efficiency state values and the current building efficiency state value. The processor may further be configured to determine whether the building efficiency state deviation value satisfies a building inefficiency threshold.

Abstract: In an aspect, an HVAC system includes an inducer motor to provide combustion airflow, and a pressure sensor to measure an output airflow pressure of the inducer motor. The HVAC system may initiate the inducer motor, and receive a pulse width modulation (PWM) signal from the inducer motor, wherein the PWM signal indicates a PWM signal of the inducer motor corresponding to a predetermined airflow pressure of the inducer motor and measured by the pressure sensor. The HVAC system may compare the PWM signal to a baseline value, and control the inducer motor based on the comparing of the PWM signal to the baseline value. The HVAC system may also generate a status notification of the combustion airflow of the HVAC system in response to the comparing the PWM signal to the baseline value.

Abstract: A system faults to a return air sensor integrated within a heating, ventilation, and air conditioning (HVAC) unit. The system transmits a signal to a remote sensor. The system determines that a return signal is not received from the remote sensor. The system obtains a temperature reading from the return air sensor. The system determines whether the temperature reading satisfies a temperature setting stored in the memory. In response to determining that the temperature reading does not satisfy the temperature setting, the system enables heating or cooling of the HVAC unit until the temperature setting is satisfied. In response to determining that the temperature reading satisfies the temperature setting, the system disables heating or cooling of the HVAC unit.

Abstract: A climate control unit (e.g., for a residential building) may include a heat exchanger, a blower that circulates air from a return duct, across the heat exchanger, to a supply duct, and a filter that cleans the air before entering the heat exchanger. The effectiveness and/or efficiency of the filter may decrease as the filter collects particles. The climate control unit may include a controller configured to set a baseline measurement according to measurements of a blower property after a reset event. The controller may be configured to measure a deviation of the blower property from the baseline measurement of the blower property. The controller may be configured to generate a status notification in response to the deviation satisfying a threshold. The status notification may indicate that the filter should be changed.