Abstract: The present invention relates to a pharmaceutical composition comprising a solid suspension prepared by hot melt extrusion of isobutyric acid (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl ester; hydrochloride salt (I) and a polyethylene glycol (PEG)/polypropylene glycol (PPG) block copolymer.

Abstract: A control cartridge has a circuit board that includes a Hall effect sensor, the position of which is fixed in a housing that has a cam. The control cartridge includes a shaft that carries a magnet and that rotates and translates with respect to the housing. The shaft has a cam follower that engages the cam and translates the shaft with respect to the housing when the shaft is rotated with respect to the housing in one direction but not in an opposite direction. The control cartridge is shown as part of a control handle for a motorcycle in which the relative angular position of the shaft with respect to the Hall effect sensor is used to control engine speed manually while the relative axial position of the shaft with respect to the Hall effect sensor is used to deactivate a cruise control.

Abstract: This invention concerns a method of substituting a chlorine atom for a predetermined hydrogen atom located within an organic compound which comprises contacting the organic compound containing the predetermined hydrogen atom with an esterifying agent comprising a pyridine ring or a substituted or fused ring derivative of a pyridine ring so as to produce an ester and treating the ester with a chlorinating agent so as to substitute the chlorine atom for the predetermined hydrogen atom. The ester comprises the pyridine ring or the substituted or fused ring derivative of the pyridine ring so positioned within the ester with respect to the predetermined hydrogen atom that a chlorine atom attached to the nitrogen atom of the pyridine ring or substituted or fused ring derivative of the pyridine ring reacts with the predetermined hydrogen atom.