Patents by Inventor Michael Brasch
Michael Brasch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11845919Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.Type: GrantFiled: May 13, 2016Date of Patent: December 19, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Song Shi, Xiaofei Chang, James Y. Zhou, Michael A. Brasch
-
Patent number: 11840719Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: July 13, 2020Date of Patent: December 12, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
-
Publication number: 20230360415Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.Type: ApplicationFiled: June 27, 2023Publication date: November 9, 2023Applicant: BECTON, DICKINSON AND COMPANYInventors: Michael A. Brasch, Curtis M. Gosnell, Timothy M. Wiles, Raphael Rodolphe Marcelpoil, Bas Nieuwenhuis, Trienko Marten Van Der Kaap, Michael Bois
-
Patent number: 11727699Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.Type: GrantFiled: October 4, 2018Date of Patent: August 15, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Michael A. Brasch, Curtis M. Gosnell, Timothy M. Wiles, Raphael Rodolphe Marcelpoil, Bas Nieuwenhuis, Trienko Marten Van Der Kaap, Michael Bois
-
Publication number: 20220074831Abstract: Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.Type: ApplicationFiled: January 23, 2020Publication date: March 10, 2022Applicant: BECTON DICKINSON AND COMPANYInventors: Qihua Xu, Kristin Weidemaier, Jon E. Salomon, Alexander G. Lastovich, Eric A. Fallows, Sean Connell, Joshua Herr, Meghan Wolfgang, Michael A. Brasch, Richard L. Moore, David S. Sebba, Cristian Clavijo, Shirley Ng, Richard Abbott, Alexander Adam Papp, Henry Li-Wei Fu, Caitlin Marie Austin, Sean Patrick Dowling, Owen Lewis Joyce, Michael L. Kiplinger, William Kevin Carpenter
-
Patent number: 11110416Abstract: A device for collecting a biological sample from a semi-solid surface. The device has a shaft with a proximate end and a distal end and a tip integrated with the shaft at the proximate end. The tip has a surface adapted to collect microorganisms thereon or release microorganism from, or both, wherein the adapted surface comprises at least one feature of a recess or extension to increase surface area of the tip and collect microorganisms thereon. Examples of such features include microfeatures with dimensions of about 1000 ?m or less. Other examples include a pipette tip.Type: GrantFiled: April 8, 2016Date of Patent: September 7, 2021Assignee: BECTON, DICKINSON AND COMPANYInventors: Timothy Mark Wiles, Dwight Livingston, Jennifer Singelyn, William Alan Fox, Brian Reuben Langhoff, Vikram Patel, Sean Tucker, Ming-hsiung Yeh, Michael A. Brasch
-
Publication number: 20200407677Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample.Type: ApplicationFiled: September 14, 2020Publication date: December 31, 2020Applicant: BECTON DICKINSON AND COMPANYInventors: Patrick Shawn Beaty, Michael A. Brasch, Suneil Hosmane, David Polley, Julie L. Rosales, Kerry Lynn Smith
-
Publication number: 20200340029Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Inventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
-
Patent number: 10808217Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample.Type: GrantFiled: October 14, 2015Date of Patent: October 20, 2020Assignee: BECTON DICKINSON AND COMPANYInventors: Patrick Shawn Beaty, Michael A. Brasch, Suneil Hosmane, David Polley, Julie L. Rosales, Kerry Lynn Smith
-
Patent number: 10767146Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: October 24, 2014Date of Patent: September 8, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Eric Ursprung, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
-
Publication number: 20200242329Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.Type: ApplicationFiled: October 4, 2018Publication date: July 30, 2020Applicant: BECTON DICKINSON AND COMPANYInventors: Michael A. Brasch, Curtis M. Gosnell, Timothy M. Wiles, Raphael Rodolphe Marcelpoil, Bas Nieuwenhuis, Trienko Marten Van Der Kaap, Michael Bois
-
Publication number: 20190078043Abstract: A container for culturing a blood sample. The container has a reservoir that is no larger than about 40 ml in volume with culture media therein varying in amount by volume 0.5 ml to about 20 ml. The container is adapted to receive a blood sample drawn from a patient, wherein the blood volume is about 1 ml to about 20 ml. In some embodiments the ratio of blood volume to culture media volume is about 2:1 to about 1:2 and the volume of blood does not exceed about 10 ml. In some embodiments, the media is lytic media. A method for using the container to culture a blood sample is also contemplated. In such method, the container is inoculated with the blood sample. In certain embodiments, the volume of the blood sample does not exceed 10 mls.Type: ApplicationFiled: May 13, 2016Publication date: March 14, 2019Applicant: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Song Shi, Xiaofei Chang, James Y. Zhou, Michael A. Brasch
-
Patent number: 9970896Abstract: An array of micro-chambers (220) with ISFETs (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390).Type: GrantFiled: May 23, 2017Date of Patent: May 15, 2018Assignee: Becton, Dickinson and CompanyInventors: Song Shi, James G. Nadeau, Michael A. Brasch
-
Publication number: 20180126343Abstract: A device for collecting a biological sample from a semi-solid surface. The device has a shaft with a proximate end and a distal end and a tip integrated with the shaft at the proximate end. The tip has a surface adapted to collect microorganisms thereon or release microorganism from, or both, wherein the adapted surface comprises at least one feature of a recess or extension to increase surface area of the tip and collect microorganisms thereon. Examples of such features include microfeatures with dimensions of about 1000 ?m or less. Other examples include a pipette tip.Type: ApplicationFiled: April 8, 2016Publication date: May 10, 2018Applicant: Becton Dickinson and CompanyInventors: Timothy Mark WILES, Dwight LIVINGSTON, Jennifer SINGELYN, William Alan FOX, Brian Reuben LANGHOFF, Vikram PATEL, Sean TUCKER, Ming-hsiung YEH, Michael A. BRASCH
-
Publication number: 20170261464Abstract: An array of micro-chambers (220) with ISFETs (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390).Type: ApplicationFiled: May 23, 2017Publication date: September 14, 2017Inventors: Song Shi, James G. Nadeau, Michael A. Brasch
-
Publication number: 20170240855Abstract: A system and method with increased sensitivity to microorganism growth. The system includes signal processing electronic circuit connected to a consumable or vessel through two or more electrodes that fully penetrate the vessel and are in contact with the fluid contents. The electronic circuit is configured to detect a component of the total impedance of the sample, specifically the “out-of-phase” or imaginary reactance component, which has a sensitive response to organism growth in a frequency-dependent manner. The system detects changes in both the composition of charged molecules in the liquid matrix and the number of microorganisms based on monitoring the sample for change in this parameter. This results in a 5-70% reduction in time-to-detection (TTD). The system and method detect organisms in a plurality of vessel shapes, volumes, and matrix (or media) formats. The electrodes are fully immersed in a continuous body of liquid sample.Type: ApplicationFiled: October 14, 2015Publication date: August 24, 2017Applicant: Becton, Dickinson and CompanyInventors: Patrick Shawn Beaty, Michael A. Brasch, Suneil Hosmane, David Polley, Julie L. Rosales, Kerry Lynn Smith
-
Patent number: 9671364Abstract: An array of micro-chambers (220) with individual ion sensitive field effect transistors (ISFETs) (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390). In addition to the presence or absence of a single cell, certain further embodiments contemplate monitoring cell behavior. Cell behavior includes the entire range of cell activity as well as cell response to changes in environmental conditions of changes in response due to the addition of sample constituents.Type: GrantFiled: December 19, 2012Date of Patent: June 6, 2017Assignee: Becton, Dickinson and CompanyInventors: Song Shi, James G. Nadeau, Michael A. Brasch
-
Publication number: 20160265022Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: October 24, 2014Publication date: September 15, 2016Applicant: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
-
Publication number: 20160251664Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different.Type: ApplicationFiled: March 3, 2016Publication date: September 1, 2016Inventors: Jonathan Chesnut, John Carrino, Louis Leong, Knut Madden, Matin Gleeson, James Fan, Michael Brasch, David Cheo, James Hartley, Devon Byrd, Gary Temple
-
Publication number: 20160222379Abstract: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the molecules are inserted into distinct sites in a vector. The invention also generally provides for linking or joining through recombination a number of molecules and/or compounds (e.g., chemical compounds, drugs, proteins or peptides, lipids, nucleic acids, carbohydrates, etc.) which may be the same or different. Such molecules and/or compounds or combinations of such molecules and/or compounds can also be bound through recombination to various structures or supports according to the invention.Type: ApplicationFiled: September 4, 2015Publication date: August 4, 2016Inventors: MICHAEL BRASCH, DEVON BYRD, DAVID CHEO, JAMES HARTLEY, GARY TEMPLE