Abstract: In some examples, a system includes an article of personal protective equipment (PPE) having at least one sensor configured to generate a stream of usage data; and an analytical stream processing component comprising: a communication component that receives the stream of usage data; a memory configured to store at least a portion of the stream of usage data and at least one model for detecting a safety event signature, wherein the at least one model is trained based as least in part on a set of usage data generated by one or more other articles of PPE of a same type as the article of PPE; and one or more computer processors configured to: detect the safety event signature in the stream of usage data based on processing the stream of usage data with the model, and generate an output in response to detecting the safety event signature.

Abstract: A communications panel includes a chassis receiving one or more tray arrangements that each support one or more cassettes. Each cassette carries a plurality of ports at which connections are made between front and rear plug connectors. Each tray arrangement includes guides along which the cassettes slidably mount. The guides and cassettes are configured to enable cassettes of various size to mount to the same tray without reconfiguring the guides.

Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: A protective clothing equipment is provided that is comfortable, stabilizing, and compatible with varying types of surfaces. One embodiment of the protective clothing equipment includes a shell, padding disposed in front of the knee of the wearer, the padding including a non-uniform stiffness.

Abstract: Stabilized cutting tool assemblies. A cutting tool assembly for use with a reference surface includes a tool holder having a rotational axis. The tool holder is arranged for attachment to a drive source arranged to rotate the tool holder and move the tool holder relative to a reference surface. The cutting tool assembly includes a rotatable cutting tool coupled to the tool holder. The cutting tool includes a cutting surface and has a first portion and a second portion. The first portion is disposed adjacent the tool holder. The cutting tool assembly includes a stabilizer coupled to the cutting tool adjacent the second portion. The stabilizer has a bearing surface. The bearing surface is positioned on the second portion to abut the reference surface and to stabilize the cutting tool when the drive source moves the tool holder and the cutting tool to a position adjacent the reference surface.

Abstract: Stabilized cutting tool assemblies. A cutting tool assembly for use with a reference surface includes a tool holder having a rotational axis. The tool holder is arranged for attachment to a drive source arranged to rotate the tool holder and move the tool holder relative to a reference surface. The cutting tool assembly includes a rotatable cutting tool coupled to the tool holder. The cutting tool includes a cutting surface and has a first portion and a second portion. The first portion is disposed adjacent the tool holder. The cutting tool assembly includes a stabilizer coupled to the cutting tool adjacent the second portion. The stabilizer has a bearing surface. The bearing surface is positioned on the second portion to abut the reference surface and to stabilize the cutting tool when the drive source moves the tool holder and the cutting tool to a position adjacent the reference surface.

Abstract: Stabilized cutting tool assemblies. A cutting tool assembly for use with a reference surface includes a tool holder having a rotational axis. The tool holder is arranged for attachment to a drive source arranged to rotate the tool holder and move the tool holder relative to a reference surface. The cutting tool assembly includes a rotatable cutting tool coupled to the tool holder. The cutting tool includes a cutting surface and has a first portion and a second portion. The first portion is disposed adjacent the tool holder. The cutting tool assembly includes a stabilizer coupled to the cutting tool adjacent the second portion. The stabilizer has a bearing surface. The bearing surface is positioned on the second portion to abut the reference surface and to stabilize the cutting tool when the drive source moves the tool holder and the cutting tool to a position adjacent the reference surface.

Abstract: The orthodontic alignment of misaligned teeth includes preparing a digital and/or physical overlay model which is the superimposed positioning of the patient's original misaligned dentition with the target or final position. The superimposition of one upon the other creates an open space through which teeth may move in a natural manner, allowing for a treatment plan that takes into account the physical interaction of one tooth with another or the differences in tooth movement rates due in part to differences in underlying bone density or the like. An aligner tray fabricated using the model will likewise represent the before and after tooth positions and will also have the open space to allow tooth movement. Force exerting structures are preferably placed into the aligner tray to impinge upon the patient's teeth in a prescribed manner when the aligner tray is inserted into the patient's oral cavity.

Abstract: The orthodontic alignment of misaligned teeth includes preparing a digital and/or physical overlay model which is the superimposed positioning of the patient's original misaligned dentition with the target or final position. The superimposition of one upon the other creates an open space through which teeth may move in a natural manner, allowing for a treatment plan that takes into account the physical interaction of one tooth with another or the differences in tooth movement rates due in part to differences in underlying bone density or the like. An aligner tray fabricated using the model will likewise represent the before and after tooth positions and will also have the open space to allow tooth movement. Force exerting structures are preferably placed into the aligner tray to impinge upon the patient's teeth in a prescribed manner when the aligner tray is inserted into the patient's oral cavity.

Abstract: Thermoforming of plastic sheets over a model includes varying the thickness in the area that is stretched over the model so that when it thins it becomes more uniform in thickness. The plastic sheet is fabricated in a substantially uniform thickness but with a preformed a complex profile or 3D area that partially builds in part of the area that would be stretched so that it thins much less than a flat sheet. Combinations of these elements may also be made.

Abstract: The orthodontic alignment of misaligned teeth includes preparing a digital and/or physical overlay model which is the superimposed positioning of the patient's original misaligned dentition with the target or final position. The superimposition of one upon the other creates an open space through which teeth may move in a natural manner, allowing for a treatment plan that takes into account the physical interaction of one tooth with another or the differences in tooth movement rates due in part to differences in underlying bone density or the like. An aligner tray fabricated using the model will likewise represent the before and after tooth positions and will also have the open space to allow tooth movement. Force exerting structures are preferably placed into the aligner tray to impinge upon the patient's teeth in a prescribed manner when the aligner tray is inserted into the patient's oral cavity.

Abstract: An article-handling system and method of handling articles with article trays having a support surface and a plurality of generally parallel grooves in said support surface includes loading articles on trays with an article-traying subsystem and unloading articles from trays with an article-detraying subsystem. The article-traying subsystem has a tray conveyor and a loading article conveyor. The loading article conveyor has a plurality of fingers adapted to fit within the grooves of a tray traveling on the tray conveyor at the article conveyor. An article is transferred to the tray support surface with the loading article conveyor. The article-detraying subsystem has a trayed article conveyor and an unloading article conveyor. The unloading article conveyor has a plurality of fingers adapted to fit within the grooves of the tray of a trayed article traveling on the trayed article conveyor at the unloading article conveyor.

Abstract: The orthodontic alignment of misaligned teeth includes preparing a digital and/or physical overlay model which is the superimposed positioning of the patient's original misaligned dentition with the target or final position. The superimposition of one upon the other creates an open space through which teeth may move in a natural manner, allowing for a treatment plan that takes into account the physical interaction of one tooth with another or the differences in tooth movement rates due in part to differences in underlying bone density or the like. An aligner tray fabricated using the model will likewise represent the before and after tooth positions and will also have the open space to allow tooth movement. Force exerting structures are preferably placed into the aligner tray to impinge upon the patient's teeth in a prescribed manner when the aligner tray is inserted into the patient's oral cavity.

Abstract: Thermoforming of plastic sheets over a model includes varying the thickness in the area that is stretched over the model so that when it thins it becomes more uniform in thickness. The plastic sheet is fabricated in a substantially uniform thickness but with a preformed a complex profile or 3D area that partially builds in part of the area that would be stretched so that it thins much less than a flat sheet. Combinations of these elements may also be made.

Abstract: A method of making a composite sheet material in which at least one lamina of previously unused expanded polystyrene is bonded to a second lamina of recycled expanded polystyrene. The laminae are continuously formed from separate extruders and are merged promptly after extrusion. Heat is applied to the laminae just before they are merged.

Abstract: A ring supported mobile lift crane includes a load carrier and a counterweight carrier in riding contact with the ring and a tower mounted on the carrier for pivotal movement between generally horizontal and vertical positions with a boom pivoted to the outer end of the tower and a rearwardly inclined mast mounted on said carrier and connected to the counterweight carrier by rigging a mast pendant, a tower backstay connected to the top of the tower and through tower hoist rigging to the top of the mast.

Abstract: A tower crane is carried on a platform rotatably mounted on a large ring with the tower pivotally mounted on the forward portion of the platform above the ring and a mast mounted on the platform adjacent the boom and extending upwardly and rearwardly therefrom. A counterweight support at the rear end of the platform also rides on the ring and is connected to the top of the mast by a backstay. At the top of the tower is a pivotally mounted, forwardly projecting boom and an upwardly and rearwardly inclined boom strut whose upper end is pin-connected to the top of the mast by a backstay strut. A tower backstay is connected to an upper part of the tower and extends generally horizontally rearwardly to the top of the mast where it is also pin-connected. By removing the pin-connections at the top of the mast, the tower, boom, boom strut, backstay strut and tower backstay can be pivotally raised and lowered as a unit by powered erection rigging mounted on the platform.