Patents by Inventor Michael C. Pirrung
Michael C. Pirrung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20030235853Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: ApplicationFiled: May 2, 2003Publication date: December 25, 2003Applicant: Affymetrix, INC.Inventors: Lubert Stryer, Stephen P.A. Fodor, J. Leighton Read, Michael C. Pirrung
-
Patent number: 6660234Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: GrantFiled: May 15, 2002Date of Patent: December 9, 2003Assignee: Affymetrix, Inc.Inventors: Luburt Stryer, Stephen P. A. Fodor, J. Leighton Read, Michael C. Pirrung
-
Patent number: 6646243Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: GrantFiled: March 15, 2002Date of Patent: November 11, 2003Assignee: Affymetrix, Inc.Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer
-
Patent number: 6630308Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: GrantFiled: December 6, 2001Date of Patent: October 7, 2003Assignee: Affymetrix, Inc.Inventors: Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor
-
Publication number: 20030170637Abstract: A method for determining the exons present in a potentially variantly spliced mRNA is carried out by: (a) providing a potentially variantly spliced mRNA; (b) providing an array, the array comprising a plurality of different primers immobilized on a solid support at distinct locations thereon, with each of the plurality of different primers selectively hybridizing to a corresponding one of the plurality of exons potentially within the mRNA; (c) contacting the mRNA to the array that a duplex is formed between each different primer and each corresponding exon if the corresponding exon is included in the mRNA; (d) subjecting the duplexes to a primer extension reaction so that the primers in the duplexes are extended with at least one labeled base; and then (e) detecting the presence or absence of the at least one labeled base in each of the plurality of primers, the presence of the at least one labeled base indicating the presence of the exon to which the primer selectively binds in the potentially variantly spliType: ApplicationFiled: March 6, 2002Publication date: September 11, 2003Inventors: Michael C. Pirrung, Hyunsoo Kim
-
Patent number: 6610482Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.Type: GrantFiled: April 24, 2000Date of Patent: August 26, 2003Assignee: Affymetrix, Inc.Inventors: Stephen P. A. Fodor, Michael C. Pirrung, Lubert Stryer, J. Leighton Read
-
Patent number: 6600031Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: GrantFiled: April 21, 1998Date of Patent: July 29, 2003Assignee: Affymetrix, Inc.Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
-
Publication number: 20030119008Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: ApplicationFiled: December 28, 2001Publication date: June 26, 2003Applicant: Affymetrix, Inc.Inventors: Stephen P.A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
-
Publication number: 20030108899Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: ApplicationFiled: July 8, 2002Publication date: June 12, 2003Applicant: Affymetrix, INC.Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read
-
Patent number: 6566495Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: GrantFiled: December 17, 1999Date of Patent: May 20, 2003Assignee: Affymetrix, Inc.Inventors: Stephen P. A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung
-
Publication number: 20030064391Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: ApplicationFiled: May 20, 2002Publication date: April 3, 2003Applicant: Affymetrix, Inc.Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer
-
Publication number: 20030013100Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: ApplicationFiled: March 15, 2002Publication date: January 16, 2003Applicant: Affymetrix, INC.Inventors: Stephen P.A. Fodor, J. Leighton Read, Lubert Stryer, Michael C. Pirrung
-
Patent number: 6506558Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: GrantFiled: November 29, 1995Date of Patent: January 14, 2003Assignee: Affymetrix Inc.Inventors: Stephen P. A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich, Jr.
-
Publication number: 20020192693Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: ApplicationFiled: May 15, 2002Publication date: December 19, 2002Applicant: Affymetrix, Inc.Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P.A. Fodor, Lubert Stryer
-
Publication number: 20020155588Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: ApplicationFiled: September 5, 2001Publication date: October 24, 2002Applicant: Affymetrix, Inc.Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read
-
Publication number: 20020137096Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: ApplicationFiled: December 14, 2001Publication date: September 26, 2002Applicant: Affymetrix, Inc.Inventors: Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, J. Leighton Read, Paul D. Hoeprich
-
Patent number: 6420169Abstract: A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a second predefined region of the substrate. The irradiation step removes a protecting group therefrom. The substrate is contacted with a first nucleotide to couple the nucleotide to the substrate in the first predefined region. By repeating these steps, an array of diverse oligonucleotides is formed on the substrate.Type: GrantFiled: November 30, 1994Date of Patent: July 16, 2002Assignee: Affymetrix, Inc.Inventors: J. Leighton Read, Stephen P.A. Fodor, Lubert Stryer, Michael C. Pirrung, Paul D. Hoeprich, Jr.
-
Patent number: 6416952Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.Type: GrantFiled: September 1, 2000Date of Patent: July 9, 2002Assignee: Affymetrix, Inc.Inventors: Michael C. Pirrung, Lubert Stryer, Stephen P. A. Fodor, J. Leighton Read
-
Publication number: 20020076832Abstract: The present invention relates, in general, to a method of attaching a biopolymer to a solid support and, in particular, to a method of attaching a nucleic acid to a glass surface, and to reagents suitable for use in such a method. The invention further relates to the product produced by the present method and to kits comprising same.Type: ApplicationFiled: June 4, 2001Publication date: June 20, 2002Inventors: Michael C. Pirrung, Amy L. Odenbaugh, Richard V. Connors, Janice D. Worden
-
Patent number: 6406844Abstract: A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are exposed to light so as to activate the selected areas. A monomer, also containing a photoremovable group, is provided to the substrate to bind at the selected areas. The process is repeated using a variety of monomers such as amino acids until sequences of a desired length are obtained. Detection methods and apparatus are also disclosed.Type: GrantFiled: June 1, 1995Date of Patent: June 18, 2002Assignee: Affymetrix, Inc.Inventors: Michael C. Pirrung, J. Leighton Read, Stephen P. A. Fodor, Lubert Stryer