Abstract: An applicator instrument for dispensing surgical fasteners includes a handle and an articulating shaft extending from the handle including proximal and distal shaft sections and an articulating joint interconnecting the proximal and distal shaft sections. The proximal shaft section has a proximal outer tube and a proximal inner member, and the distal shaft section includes a distal outer tube and a distal inner member. An incompressible member interconnects the proximal and distal inner members to form an inner shaft member having a fixed length. Distal movement of the proximal outer tube relative to the proximal inner member articulates the distal shaft section relative to the proximal shaft section via the articulating joint. As the articulating shaft moves between a straight configuration and an articulated configuration the distance between a distal-most end of the distal outer tube and the handle changes while the length of the inner shaft member remains fixed.

Abstract: A system for deploying a suture implant includes a delivery device and a suture implant coupled with the distal end of the delivery device. The suture implant includes a suture and a slip knot that defines a suture loop, the slip knot defining a dynamic end of the suture loop that is located opposite a closed end of the suture loop. The suture implant includes a tissue anchor having first and second openings, whereby the closed end of the suture loop passes through the first and second openings for securing the tissue anchor to the suture loop. A tensioner is secured to the first end of the suture, and a pledget, located between the tensioner and the tissue anchor, is secured to the second end of the suture. Pulling the tensioner away from the tissue anchor slides the pledget and the slip knot toward the tissue anchor for shortening the length of the suture loop and reducing the distance between the pledget and the tissue anchor.

Abstract: An applicator instrument having a reconfigurable handle for dispensing surgical fasteners includes a housing having a proximal end and a distal end, an elongated shaft extending from the housing, a handle coupled with the proximal end of the housing, and a trigger coupled with the handle. The applicator instrument has a firing system including an energy storing assembly that is disposed within the housing, and a gear train disposed within the handle and coupled with the trigger. The trigger is squeezed for commencing a firing cycle and storing energy in the energy storing assembly. The applicator instrument includes a handle reconfiguration actuator having a first position for locking the handle in place relative to the housing and a second position for enabling the handle to rotate relative to the housing between a pistol configuration and an in-line configuration.

Abstract: A medical device for making foam includes a syringe having a plunger for dispensing a liquid from a liquid dispensing port, and a mixing chamber including a mixing chamber inlet, a mixing chamber outlet, a liquid flow channel extending between the mixing chamber inlet and the mixing chamber outlet, and a gas inlet channel that intersects with the liquid flow channel. The system has a gas cartridge containing the gas, a first gas conduit connected with the syringe, and a second gas conduit connected with the gas inlet channel. An actuator is coupled with the gas cartridge for releasing the gas into the first and second gas conduits. The released gas in the first gas conduit forces the plunger toward the liquid dispensing port for dispensing the liquid from the liquid dispensing port and into the liquid flow channel while the released gas in the second gas conduit flows into the gas inlet channel of the mixing chamber for mixing with the liquid in the liquid flow channel.

Abstract: An applicator instrument for dispensing surgical fasteners includes an elongated shaft having a proximal shaft section and a distal shaft section. The proximal shaft section includes an outer sheath and the distal shaft section includes a segmented member moveable between straight and articulated configurations. A handle is secured to the proximal shaft section, and an actuator is provided on the handle that is coupled with the outer sheath. An articulation band is disposed within the outer sheath and extends from the handle to the segmented member. The articulation band has a proximal end coupled with the actuator and a distal end attached to the segmented member. The actuator is moveable in a first direction for retracting the outer sheath, exposing the segmented member, and applying tension to the articulation band for moving the segmented member into the articulated configuration.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft having a proximal shaft section and an articulating distal shaft section extending from the housing, a firing system disposed within the housing, an actuator that is engageable for commencing a firing cycle of the firing system, and an articulation lever provided on the housing for selectively articulating the articulating distal shaft section of the elongated shaft. The applicator instrument includes a cam plate disposed within the housing that is linked with the articulating distal shaft section and that coupled with the articulation lever for being rotated by the articulation lever between a first or horizontal position for straightening the articulating distal shaft section and a second or vertical position for articulating the articulating distal shaft section.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, a firing system disposed in the housing and moveable in distal and proximal directions along a first axis, a handle extending upwardly from the housing along a second axis that defines an acute angle with the first axis, and a trigger mounted on the handle. The applicator instrument includes a non-linear elongated shaft extending from the housing that has a distal section that is extends upwardly toward a top of said applicator instrument. A distal end cap is secured to the distal end of the elongated shaft. The applicator has an imaging system including an imaging device for detecting images at the distal end of said applicator instrument, and a light source for illuminating a field of view for the imaging device at the distal end of the applicator instrument.

Abstract: A surgical fastener includes a first leg having a first distal barb and a first proximal barb that extend inwardly, and a second leg having a second distal barb and a second proximal barb that extend inwardly. A bridge interconnects proximal ends of the first and second legs. A first distance between opposing inner tips of the first and second distal barbs is greater than a second distance between opposing inner tips of the first and second proximal barbs. The first leg tapers inwardly between the proximal and distal ends thereof and has a cross-sectional area that is greater at the proximal end than at the distal end. The second leg tapers inwardly between the proximal and distal ends thereof and has a cross-sectional area that is greater at the proximal end than at the distal end. An insertion tool engages a crown on the proximal side of the bridge.

Abstract: The present disclosure relates to a method for preparing a haemostatic composition comprising thrombin, the method comprising the step of reconstituting a dry thrombin directly in a paste, such as a paste comprising a biocompatible polymer. The haemostatic composition comprising thrombin may be prepared from a dry thrombin composition and a paste in a single step operation and be used for treatment of a wound.

Abstract: An ultrasound system for planning a surgical implantation of a prosthetic aortic valve produces three dimensional images of the aortic root region of a patient. An electronic model of an aortic root is accessed and fitted to the aortic root in a three dimensional ultrasound image. Preferably the aortic root model exhibits closed contour cross-sections which are fitted to the endothelial lining of the aortic root in the ultrasound image. A medial axis of the fitted model is identified and radii measured from the medical axis to the border of the fitted model. The radii are joined to identify a surface forming a mesh model fitted to the aortic root anatomy of the patient. The shape and dimensions of the fitted model may be used to fabricate a custom prosthetic valve for aortic valve replacement.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, and an elongated shaft extending from the housing. The elongated shaft has a proximal end secured to the housing, a distal end spaced from the proximal end, and a first axis extending between the proximal and distal ends of the elongated shaft. Surgical fasteners are disposed in the elongated shaft. The surgical fasteners are stacked at an angle relative to the first axis of the elongated shaft. A distal end cap having a surgical fastener dispensing window is secured to the distal end of the elongated shaft. The applicator instrument has a firing system disposed in the housing, and an actuator coupled with the firing system for activating the firing system to dispense the surgical fasteners through the surgical fastener dispensing window.

Abstract: Various methods are disclosed for additively manufacturing a feedstock material to create an AM preform, wherein the AM preform is configured with a body having an internal passage defined therein, wherein the internal passage further includes at least one of a void and a channel; inserting a filler material into the internal passage of the AM preform; closing the AM preform with an enclosure component such that the filler material is retained within the internal passage of the AM preform; and deforming the AM preform to a sufficient amount to create a product having an internal passage therein, wherein the product is configured with wrought properties for that material via the deforming step.

Abstract: An apparatus and process for formation of a multicomponent metal alloy ingot or product in which granulated metal feedstock, under a high pressure inert environment, is introduced onto a rotating platen or previously deposited layer on the rotating platen. As the granulated feedstock is deposited on the platen, the platen is rotated such that a segment of the platen having the feedstock thereon passes through an energy generator field such as a melting laser beam or eddy current induction melting field. As it passes it is melted to form an arcuate segment of melt. The melt is then rotated out from under the energy beam and cooled into a solid state of the desired alloy as a next contiguous segment of feedstock is introduced and the process repeated until a layer is formed. The platen may then be indexed lower and a new layer is formed in the same manner.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, a firing system moveable along a first axis, a handle extending upwardly from the housing along a second axis that defines an acute angle with the first axis, the handle having an upper free end that defines a top of the applicator instrument, a trigger coupled with the housing for activating the firing system, and an elongated shaft extending from the distal end of the housing, the elongated shaft having a proximal shaft section extending along the first axis and a distal shaft section that is oriented at an angle relative to the proximal shaft section for extending upwardly toward the top of the applicator instrument. The trigger is squeezed for dispensing surgical fasteners from the distal end of the elongated shaft. The applicator instrument has at least one visual indicator for indicating a proper orientation for the applicator instrument in which the upper free end of the handle is positioned above the housing.

Abstract: An applicator instrument for dispensing surgical fasteners including a housing, an elongated shaft extending from the housing, surgical fasteners disposed in the elongated shaft, a firing system for dispensing the surgical fasteners from the distal end of the elongated shaft, and a trigger coupled with the housing for activating the firing system. The firing system includes a firing rod disposed in the elongated shaft and an energy storing element disposed in the housing for building up energy for dispensing the surgical fasteners from the distal end of the elongated shaft.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, a firing system disposed in the housing, an actuator coupled with the housing for activating the firing system, an elongated shaft extending from the housing, the elongated shaft having a proximal end secured to the housing, a distal end, and a first axis extending between the proximal and distal ends, one or more surgical fasteners disposed in the elongated shaft, and a distal end cap secured to the distal end of the elongated shaft. The distal end cap has a surgical fastener dispensing window for dispensing the one or more surgical fasteners from the distal end cap. The firing system includes a firing rod that extends through the elongated shaft for dispensing the one or more surgical fasteners from the distal end cap. The firing rod has a proximal section that moves along the first axis of the elongated shaft and a distal section that moves along a second axis that defines an angle with the first axis.

Abstract: An applicator instrument for dispensing surgical fasteners includes a handle and an articulating shaft extending from the distal end of the handle. The articulating shaft includes a proximal shaft section, a distal shaft section, and an articulating joint. An articulation control element is coupled with the proximal shaft section for articulating the distal shaft section relative to the proximal shaft section via the articulating joint. The applicator instrument includes an incompressible member interconnecting the proximal and distal shaft sections that maintains a fixed distance between the distal end face of the distal shaft section and the distal end of the handle as the articulating shaft moves between a straight configuration and an articulated configuration to ensure a consistent firing stroke.

Abstract: Novel mesh implant positioning systems for use in laparoscopic body wall defect repairs, such as hernia defects, are disclosed. The systems utilize one or more bar members combined with surgical sutures and needles to position a mesh implant adjacent to a body wall defect without the need for stay sutures. Also disclosed are assemblies of the positioning systems with surgical mesh repair implants, and methods of repairing body wall defects such as hernias with the assemblies.

Abstract: A system for deploying a suture implant includes a delivery device and a suture implant coupled with the distal end of the delivery device. The suture implant includes a suture and a slip knot that defines a suture loop, the slip knot defining a dynamic end of the suture loop that is located opposite a closed end of the suture loop. The suture implant includes a tissue anchor having first and second openings, whereby the closed end of the suture loop passes through the first and second openings for securing the tissue anchor to the suture loop. A tensioner is secured to the first end of the suture, and a pledget, located between the tensioner and the tissue anchor, is secured to the second end of the suture. Pulling the tensioner away from the tissue anchor slides the pledget and the slip knot toward the tissue anchor for shortening the length of the suture loop and reducing the distance between the pledget and the tissue anchor.

Abstract: Methods and apparatus related to executing an online multimedia game. Some implementations are directed to a method for determining a matchup of two players, receiving multimedia selections from the players of the matchup, providing the selections to other players, and determining a winner of the matchup based on ratings provided by the other players. Some implementations are directed to prompting one player of the matchup for a multimedia subject for the multimedia selections and receiving either a multimedia subject or a deferral to the other player of the matchup for selection of a multimedia subject.