Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: A fuel cell stack, a method of operating a fuel cell stack and a fuel cell system. In one particular form, shutting down the stack upon detection of a leakage of fuel either within the stack or from the stack involves depressurizing and uniform consumption of hydrogen by catalytic consumption in the cathode of all cells. Upon consumption of oxygen in the cathode portion of the stack by chemical reaction, the remaining unreacted nitrogen from the air acts as an inerting fluid. After an indication of reaction cessation is established, at least some of the inerting fluid is conveyed from the cathode portion to the anode portion. One or more of a bleed valve, backpressure valve and bypass valve are manipulated to promote the anode portion depressurization, cathode portion inerting and subsequent conveyance of the inerting fluid to the stack anode portion.

Abstract: A system and method for a cathode subsystem in a fuel cell system. The system includes a fuel cell stack, a cathode inlet line that provides cathode air to a fuel cell stack and a cathode exhaust line that exhausts a cathode exhaust gas out of the fuel cell stack. Also included is a backpressure valve in the cathode exhaust line that is located downstream of a drip rail of the cathode exhaust line, where the drip rail includes a protrusion that prevents condensed water from building up near the backpressure valve. The drip rail further includes a sump that collects drips of condensed water from the protrusion of the drip rail. The system also includes a drain below a water vapor transfer unit that includes an orifice that is in a portion of the drain that is within the cathode exhaust line.

Abstract: A fuel cell stack, a method of operating a fuel cell stack and a fuel cell system. In one particular form, shutting down the stack upon detection of a leakage of fuel either within the stack or from the stack involves depressurizing and uniform consumption of hydrogen by catalytic consumption in the cathode of all cells. Upon consumption of oxygen in the cathode portion of the stack by chemical reaction, the remaining unreacted nitrogen from the air acts as an inerting fluid. After an indication of reaction cessation is established, at least some of the inerting fluid is conveyed from the cathode portion to the anode portion. One or more of a bleed valve, backpressure valve and bypass valve are manipulated to promote the anode portion depressurization, cathode portion inerting and subsequent conveyance of the inerting fluid to the stack anode portion.

Abstract: A shear has a moveable blade assembly (7); a second fixed blade assembly; a first sensor (22) mounted on the first blade assembly; a second sensor (21) mounted on the second blade assembly; and a first sensor reference block (20) fixedly mounted relative to a fixed datum (23).

Abstract: A system and method for a cathode subsystem in a fuel cell system. The system includes a fuel cell stack, a cathode inlet line that provides cathode air to a fuel cell stack and a cathode exhaust line that exhausts a cathode exhaust gas out of the fuel cell stack. Also included is a backpressure valve in the cathode exhaust line that is located downstream of a drip rail of the cathode exhaust line, where the drip rail includes a protrusion that prevents condensed water from building up near the backpressure valve. The drip rail further includes a sump that collects drips of condensed water from the protrusion of the drip rail. The system also includes a drain below a water vapor transfer unit that includes an orifice that is in a portion of the drain that is within the cathode exhaust line.

Abstract: A method for purging water from a fuel cell stack at fuel cell system shutdown. The method includes determining a stack water generation request to control the rate of drying of membranes in the stack and determining a cathode catalytic heating water generation request. A maximum charge a battery in the fuel cell system can accept is also determined. An ancillary power request for powering components of the fuel cell system during shutdown is determined. The method allocates how much of the water generation request will be fulfilled by operating the fuel cell stack to charge the battery and to provide the power needed for the ancillary power request, and how much of the water generation request will be fulfilled by cathode catalytic heating that produces water and heat in a cathode side of the fuel cell stack.

Abstract: Methods and systems for enhancing the performance of fuel cells in fuel cell vehicles. Some embodiments comprise a current control module for controlling the application of a load to the fuel cell and a voltage monitoring module for monitoring one or more voltages within the fuel cell. The current control module may be configured to apply a delay period before applying a load to the fuel cell after the fuel cell has reached an open circuit voltage. In other embodiments, a fixed delay period may be applied before applying a load to the fuel cell after the fuel cell has reached an open circuit voltage or, for example, an incremental set of delay periods that increase as measured temperature decreases.

Abstract: A system and method for selectively determining whether a freeze purge should be performed at shut-down of a fuel cell stack. The method includes identifying that the vehicle has been keyed off and then determining whether a stack membrane humidification value is less than a predetermined humidification value that identifies the humidification of membranes in fuel cells in the fuel cell stack. If the stack membrane humidification value is not less than the predetermined humidification value, then the method determines if the ambient temperature is below a predetermined ambient temperature, and if so, performs the freeze purge. If the ambient temperature is not below the predetermined ambient temperature, then the method performs a short non-freeze purge of the flow channels in the fuel cell stack. The method determines a wake-up time for a controller for a next time to determine whether a freeze purge should be performed.

Abstract: Methods and systems for enhancing the performance of fuel cells in fuel cell vehicles. Some embodiments comprise a current control module for controlling the application of a load to the fuel cell and a voltage monitoring module for monitoring one or more voltages within the fuel cell. The current control module may be configured to apply a delay period before applying a load to the fuel cell after the fuel cell has reached an open circuit voltage. In other embodiments, a fixed delay period may be applied before applying a load to the fuel cell after the fuel cell has reached an open circuit voltage or, for example, an incremental set of delay periods that increase as measured temperature decreases.

Abstract: A system and method for selectively determining whether a freeze purge should be performed at shut-down of a fuel cell stack. The method includes identifying that the vehicle has been keyed off and then determining whether a stack membrane humidification value is less than a predetermined humidification value that identifies the humidification of membranes in fuel cells in the fuel cell stack. If the stack membrane humidification value is not less than the predetermined humidification value, then the method determines if the ambient temperature is below a predetermined ambient temperature, and if so, performs the freeze purge. If the ambient temperature is not below the predetermined ambient temperature, then the method performs a short non-freeze purge of the flow channels in the fuel cell stack. The method determines a wake-up time for a controller for a next time to determine whether a freeze purge should be performed.

Abstract: A fuel cell stack that includes catalyzed surfaces in the non-active inlet region of the cathode flow channels. At cold system start-up, hydrogen is introduced into the cathode inlet header to be mixed with air so that a chemical reaction is provided by the catalyst that generates heat to warm the cooling fluid in the non-active inlet area. Therefore, the cooling fluid that enters the active area of the stack will not be cold enough to quench the chemical reaction.

Abstract: A method for purging water from a fuel cell stack at fuel cell system shutdown. The method includes determining a stack water generation request to control the rate of drying of membranes in the stack and determining a cathode catalytic heating water generation request. A maximum charge a battery in the fuel cell system can accept is also determined. An ancillary power request for powering components of the fuel cell system during shutdown is determined. The method allocates how much of the water generation request will be fulfilled by operating the fuel cell stack to charge the battery and to provide the power needed for the ancillary power request, and how much of the water generation request will be fulfilled by cathode catalytic heating that produces water and heat in a cathode side of the fuel cell stack.

Abstract: A fuel cell system wherein a plurality of fuel cells are arranged in a series of stages, the number of fuel cells decreasing in number in each stage from anode gas inlet to the anode gas outlet. The system allows for parallel flow to all of the cells in a given stage and series flow between the various stages. A similar configuration is present on a cathode side of the system. However, the direction of flow is reversed, providing a greater number of cells in the stage nearest the cathode outlet and a fewer number of cells in the stage near the cathode gas inlet. The invention further provides for the various stages to be configured such that the direction of flow of the anode gas of a given stage is generally opposite the direction of flow of the cathode gas of a given stage.

Abstract: A fuel cell including a water blocking layer positioned between anode gas flow channels and a gas diffusion media. The blocking layer prevents water from propagating through the gas diffusion media layer and entering the anode flow channels, while allowing gas from the flow channels to flow through the diffusion media layer to the membrane. A water accumulation channel can be provided around the perimeter of the gas diffusion media layer where blocked water is accumulated, and allowed to expand during cell freezing. A porous capillary wick can be provided in the accumulation channel for wicking water to the inlet end of the flow channels where it is used to humidify the anode gas coming into the fuel cell. The wick can have a tapered configuration so that it has a larger diameter at the gas input end of the flow channels.

Abstract: A fuel cell stack that includes catalyzed surfaces in the non-active inlet region of the cathode flow channels. At cold system start-up, hydrogen is introduced into the cathode inlet header to be mixed with air so that a chemical reaction is provided by the catalyst that generates heat to warm the cooling fluid in the non-active inlet area. Therefore, the cooling fluid that enters the active area of the stack will not be cold enough to quench the chemical reaction.

Abstract: A fuel cell including a water blocking layer positioned between anode gas flow channels and a gas diffusion media. The blocking layer prevents water from propagating through the gas diffusion media layer and entering the anode flow channels, while allowing gas from the flow channels to flow through the diffusion media layer to the membrane. A water accumulation channel can be provided around the perimeter of the gas diffusion media layer where blocked water is accumulated, and allowed to expand during cell freezing. A porous capillary wick can be provided in the accumulation channel for wicking water to the inlet end of the flow channels where it is used to humidify the anode gas coming into the fuel cell. The wick can have a tapered configuration so that it has a larger diameter at the gas input end of the flow channels.

Abstract: A fuel cell system wherein a plurality of fuel cells are arranged in a series of stages, the number of fuel cells decreasing in number in each stage from anode gas inlet to the anode gas outlet. The system allows for parallel flow to all of the cells in a given stage and series flow between the various stages. A similar configuration is present on a cathode side of the system. However, the direction of flow is reversed, providing a greater number of cells in the stage nearest the cathode outlet and a fewer number of cells in the stage near the cathode gas inlet. The invention further provides for the various stages to be configured such that the direction of flow of the anode gas of a given stage is generally opposite the direction of flow of the cathode gas of a given stage.

Abstract: A bipolar plate for use in a fuel cell stack includes a first plate having a first coolant face with a first set of coolant channels formed therein. A second plate has a second coolant face with a second set of coolant channels formed therein. The first and second coolant faces are adjacent to one another to intermittently cross-link the first and second sets of coolant channels over a region of the first and second coolant faces.

Abstract: A fuel processor for rapid start and operational control. The fuel processor includes a reformer, a shift reactor, and a preferential oxidation reactor for deriving hydrogen for use in creating electricity in a plurality of H2—O2 fuel cells. A heating and cooling mechanism is coupled to at least the shift reactor for controlling the critical temperature operation of the shift reactor without the need for a separate cooling loop. This heating and cooling mechanism produces or removes thermal energy as a product of the temperature of the combustion of air and fuel. Anode effluent and cathode effluent or air are used to control the temperature output of the heating mechanism. A vaporizer is provided that heats the PrOx reactor to operating temperature.