Patents by Inventor Michael Castello

Michael Castello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND RISK OF PROGRESSION TO ALZHEIMER'S DISEASE
    Publication number: 20240026452
    Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.
    Type: Application
    Filed: June 6, 2023
    Publication date: January 25, 2024
    Inventors: Salvador Soriano, Michael Castello
  • SYSTEM FOR APPLYING THERAPY TO A HUMAN BODY
    Publication number: 20230346618
    Abstract: In one embodiment, there is provided a system for applying therapy to a human body. The system includes a coupling apparatus and a supporting apparatus. The coupling apparatus is configured to couple to an upper body portion of a user. The supporting apparatus is configured to support at least a portion of a weight of the user. An amount of weight that is supported is adjustable. In some embodiments, the system may further include a control apparatus configured to control at least one of a state and/or a position of the supporting apparatus.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 2, 2023
    Applicant: Rensselaer Polytechnic Institute
    Inventors: Eric H. Ledet, Michael Castello, Ryan Chien, Jeongwon Choi, Ruiqi Ma, Jacqueline Ray
  • Methods of diagnosing alzheimer's disease and risk of progression to alzheimer's disease
    Patent number: 11708609
    Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: July 25, 2023
    Assignee: Loma Linda University Health
    Inventors: Salvador Soriano, Michael Castello
  • SYSTEMS AND METHODS FOR DETECTION AND CORRECTION OF ABNORMAL MOVEMENTS
    Publication number: 20200375500
    Abstract: Systems and methods for identifying abnormal movements or tremors in one or more human subjects. Kinetic and/or electromyographic sensors are employed in detection hardware to detect voluntary and involuntary movements. The data collected from such voluntary and involuntary movement detection can be further processed and compared to baseline data to identify and distinguish abnormal movements from normal movements. The identification of abnormal movements may indicate a neurodegenerative disorder.
    Type: Application
    Filed: February 22, 2019
    Publication date: December 3, 2020
    Inventors: Salvador SORIANO, Michael CASTELLO
  • METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND RISK OF PROGRESSION TO ALZHEIMER'S DISEASE
    Publication number: 20190300960
    Abstract: In one aspect, methods of diagnosing a subject as having Alzheimer's disease and prognosing a subject as being at risk of progressing to Alzheimer's disease are provided. In some embodiments, the method comprises determining one or more of the level of expression of rhotekin 2 (RTKN2), the level of expression of microtubule-associated Ser/Thr kinase 4 (MAST4), the level of binding of forkhead box O1 (FOXO1) to the RTKN2 promoter, and the level of binding of amyloid precursor protein (APP) to the MAST4 promoter in a sample from the subject.
    Type: Application
    Filed: December 8, 2017
    Publication date: October 3, 2019
    Inventors: Salvador Soriano, Michael Castello
  • METHODS AND KITS FOR DETERMINING RISK FOR DEVELOPING ALZHEIMER'S DISEASE AND PREVENTION OR TREATMENT THEREOF
    Publication number: 20160320417
    Abstract: Methods are disclosed for determining a patient's risk for developing Alzheimer's disease and preventing or treating Alzheimer's disease. Kits for assessing a patient's risk of developing Alzheimer's are also provided.
    Type: Application
    Filed: April 29, 2016
    Publication date: November 3, 2016
    Inventors: Salvador Soriano, Michael Castello
  • METHODS AND KITS FOR DETERMINING RISK FOR DEVELOPING ALZHEIMER'S DISEASE AND PREVENTION OR TREATMENT THEREOF
    Publication number: 20150005351
    Abstract: Methods are disclosed for determining a patient's risk for developing Alzheimer's disease and preventing or treating Alzheimer's disease. Kits for assessing a patient's risk of developing Alzheimer's are also provided.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 1, 2015
    Inventors: Salvador Soriano, Michael Castello