Abstract: This invention provides, in some aspects, for devices and methods for protecting a sensitive structure against explosive warhead containing weaponry, whereby a protective apparatus is positioned to be facing an anticipated impact direction at a spacing from said sensitive structure, wherein said apparatus absorbs the impact of said explosive warhead containing weaponry.

Abstract: Provided herein are compounds of Formula I, or a pharmaceutically acceptable salt thereof: which are useful as PARP inhibitors, as well as pharmaceutical compositions comprising them and methods for their use in treating disorders.

Abstract: A massage device and method of massaging a user utilizes a surface which defines an internal cavity. A plurality of pressure point protrusions are formed on at least a part of the surface of the massage device. The internal cavity is filled with a medium in the form of water. The massage device and the water contained in the internal cavity are heated so that the temperature of the heated massage device in combination with the pressure point protrusions provide an enhanced therapeutic benefit.

Abstract: The present disclosure relates to techniques of configuring a layout of graphical objects for display. In one example process, the device detects a scroll request and determines whether the scroll request meets predetermined criteria. If the scroll request meets the criteria, the device configures the layout of graphical objects that are to be displayed once the display is scrolled so that the graphical objects are arranged on the display differently than the arrangement in which the graphical objects would have been displayed, had the layout not been configured. If the scroll request does not meet the criteria, the device forgoes the configuration of the layout of graphical objects.

Abstract: A computer-implemented method comprising: receiving, by a computing device, prescription information for an individual identifying a medication and a condition; identifying, by the computing device, job roles impacted by the condition; identifying, by the computing device, job roles impacted by side effects of the medication; determining, by the computing device, that a working capacity of the individual is diminished by the condition or the side effects of the medication based on job roles of the individual; generating, by the computing device, mitigation instructions in response to the determining; and executing, by the computing device, the mitigation instructions.

Abstract: The present disclosure relates to techniques of configuring a layout of graphical objects for display. In one example process, the device detects a scroll request and determines whether the scroll request meets predetermined criteria. If the scroll request meets the criteria, the device configures the layout of graphical objects that are to be displayed once the display is scrolled so that the graphical objects are arranged on the display differently than the arrangement in which the graphical objects would have been displayed, had the layout not been configured. If the scroll request does not meet the criteria, the device forgoes the configuration of the layout of graphical objects.

Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: The present application discloses an isolated nucleic acid sequence for detecting the presence of a target nucleic acid sequence, a ribozyme for detecting the presence of a target nucleic acid sequence and uses thereof.

Abstract: A massage device has an elliptical shaped housing having an upper end and a lower end and sidewalls therebetween, an upper massage surface and a lower base surface, the upper massage surface having a curvature with a peak at substantially a middle section of the upper massage surface. A central groove runs through the upper massage surface. A row of inwardly facing ribs lines at least a part of the central groove so as to extend at least partially into or over the central groove, and a plurality of rows of upwardly facing ribs are formed on the upper massage surface between the inwardly facing ribs and the upper and lower ends respectively.

Abstract: Methods, and systems for processing a request sent to a virtual assistant management system and for allocating resources, e.g., computing resources, in response to such requests. One of the methods includes: receiving a request; determining a category of the request; determining actions associated with completing the request; using a machine learning model to estimate an amount of time to complete the request based on the category and the actions associated with completing the request, wherein the machine learning model was trained using features characterizing a previous request that was completed by an agent and the time it took the agent to complete the previous request; and rating an agent's performance based in part on a comparison of an amount of time it takes an agent to complete the request and the estimated amount of time to complete the request generated by the machine learning model.

Abstract: A polypeptide biosensor that detects free NAD+ is disclosed. The polypeptide comprises a first fragment from an NAD+ dependent DNA ligase acetylation domain, a second fragment from the NAD+ dependent DNA ligase acetylation domain, and a fluorescent protein, wherein the fluorescent protein is positioned between the two DNA ligase acetylation domain fragments. Also disclosed are expression vectors comprising the biosensor as well as methods of using the biosensor to detect NAD+.

Abstract: Provided herein are compounds of Formula I, or a pharmaceutically acceptable salt thereof: which are useful as PARP inhibitors, as well as pharmaceutical compositions comprising them and methods for their use in treating disorders.

Abstract: The disclosure describes a proxy server application that supports the dynamic modification of proxy rules implemented by a proxy server. The proxy rules implemented by the proxy server specify network behaviors to be performed at various points during the handling of requests from client applications. A proxy server implements the proxy rules by processing one or more user-generated network traffic filters for managing network traffic. In an embodiment, users generate network traffic filters by creating network traffic filter source code that specify processing steps to be performed by a proxy server relative to network messages the proxy server receives. In an embodiment, user-generated network traffic filters may be added, removed, reordered, or otherwise modified in a proxy server application at runtime in order to respond to current network conditions or to achieve other desired proxy configurations.

Abstract: A computer-implemented expertise mining system is configured to update an expertise database based on a recommender's out of office and/or auto-reply settings for a communication application, such as an email application or social media application. The expertise system obtains the recommender's auto-reply settings directly from the communication application. The auto-reply settings include message body text for out of office and auto-reply messages. The expertise system then extracts recommendation data from the auto-reply settings; and updates an expertise database based on the recommendation data extracted from the auto-reply settings.

Abstract: To evaluate a network's performance in processing communications related to a target transaction, a set of “reference” communications corresponding to the target transaction are compared to a larger set of communications in the network in a “production” environment, to identify the occurrence of the target transaction in the production environment. Preferably, the reference communications are recorded in a laboratory environment that models the production environment, or recorded from the production environment during a period of minimal other activities. A variety of filters are used to eliminate communications in the production environment that are apparently unrelated to the target transaction, including filters based on the time-order of communications among the nodes, the size of the packets being communicated, and the content of the communications.

Abstract: Disclosed are various embodiments for an experience service. An experience service determines if a client device requesting a network page is to receive a modified user experience. Transformation code corresponding to the user experience is communicated to the client device. The client device executes the transformation code to modify a rendering of the requested network page.

Abstract: An integrated system for facilitating local treatment in an organ and capable of universally interfacing with other devices and systems is provided. The integrated system comprises an imaging system interface module configured to functionally associate with an imaging system capable of presenting to a user, through a user-interface device, parameters indicating a mode of operation of the imaging system. The imaging system interface module is configured to receive at least one of the parameters, to interpret such parameter and to allow the integrated system to assume a mode of operation according the parameter. The integrated system further comprises a treatment tool interface module, configured to receive and detect a treatment event signal from a portable treatment tool. The treatment event signal indicates a treatment event, thereby allowing establishing a time of the treatment event and thereby establishing a locality of a treatment provided to the organ by the portable treatment tool.

Abstract: Systems and methods are disclosed for calling desired contacts using a standalone smartphone or other portable device, selecting and using contact information from a customer relationship management (CRM) system, and automatically updating the CRM system with the outcome of each conversation. In addition, systems and methods are disclosed for automatically integrating an automated calling system with a customer relationship management system, contact management system, and/or task management system, so that historical information stored concerning past contact activity and automated calling sessions relating to contacts is automatically updated in the customer relationship management system, contact management system, and/or task management system.

Abstract: The present disclosure relates to techniques of configuring a layout of graphical objects for display. In one example process, the device detects a scroll request and determines whether the scroll request meets predetermined criteria. If the scroll request meets the criteria, the device configures the layout of graphical objects that are to be displayed once the display is scrolled so that the graphical objects are arranged on the display differently than the arrangement in which the graphical objects would have been displayed, had the layout not been configured. If the scroll request does not meet the criteria, the device forgoes the configuration of the layout of graphical objects.

Abstract: The present disclosure relates to techniques of configuring a layout of graphical objects for display. In one example process, the device detects a scroll request and determines whether the scroll request meets predetermined criteria. If the scroll request meets the criteria, the device configures the layout of graphical objects that are to be displayed once the display is scrolled so that the graphical objects are arranged on the display differently than the arrangement in which the graphical objects would have been displayed, had the layout not been configured. If the scroll request does not meet the criteria, the device forgoes the configuration of the layout of graphical objects.