Abstract: Coronavirus S ectodomain trimers stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the coronavirus S ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to coronavirus in a subject. In additional embodiments, the therapeutically effective amount of the coronavirus S ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing coronavirus infection.

Abstract: A surface mount constructed millimeter wave transceiver device and methods of making a surface mount constructed millimeter wave transceiver device are disclosed. The transceiver device includes a printed circuit board having a first waveguide port and a second waveguide port. A diplexer is surface mounted to a first side of the printed circuit board, the diplexer comprising a low frequency waveguide port and a high frequency waveguide port each coupled to an antenna port. A transmitter and a receiver are surface mounted to a second side of the printed circuit board, located opposite the first side of the printed circuit board, wherein the transmitter and the receiver comprise a transmitter waveguide port and a receiver waveguide port, respectively, that are configured to be aligned to the first waveguide port and the second waveguide port of the printed circuit board, respectively.

Abstract: The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.

Abstract: The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates thereof.

Abstract: A system is provided comprising: a materials handling vehicle; a wearable remote control device comprising: a wireless communication system including a wireless transmitter; and a rechargeable power source; a receiver at the vehicle for receiving transmissions from the wireless transmitter; a controller at the vehicle that is communicably coupled to the receiver, the controller being responsive to receipt of the transmissions from the remote control device; and a charging station at the vehicle. The charging station may charge the rechargeable power source of the wearable remote control device. The charging station may comprise a visual indicator.

Abstract: A system is provided comprising: a materials handling vehicle; a wearable remote control device comprising: a wireless communication system including a wireless transmitter; and a rechargeable power source; a receiver at the vehicle for receiving transmissions from the wireless transmitter; a controller at the vehicle that is communicably coupled to the receiver, the controller being responsive to receipt of the transmissions from the remote control device; and a charging station at the vehicle. The charging station may charge the rechargeable power source of the wearable remote control device. The charging station may comprise a visual indicator.

Abstract: Methods and apparatus for determining a functional impact of vascular lesions are disclosed. An example method includes calculating estimates of a single functional blood flow metric (for example, fractional flow reserve calculated from angiographic images) for multiple locations in each of a plurality of connected vascular branches. The method includes converting these estimates into FFR impact scores, which are indicative of the overall impact of occlusive vascular disease on the connected vascular branches.

Abstract: The present invention provides commercial processes for preparing 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3- yl)acetic acid as well as intermediates thereof.

Abstract: A system is provided comprising: a materials handling vehicle; a wearable remote control device comprising: a wireless communication system including a wireless transmitter; and a rechargeable power source; a receiver at the vehicle for receiving transmissions from the wireless transmitter; a controller at the vehicle that is communicably coupled to the receiver, the controller being responsive to receipt of the transmissions from the remote control device; and a charging station at the vehicle. The charging station may charge the rechargeable power source of the wearable remote control device. The charging station may comprise a visual indicator.

Abstract: A mechanism for moving vehicles within a vehicle parking structure comprises a lift platform which can be moved vertically and laterally to positions in register with one or more transfer rooms through which vehicles enter and leave the structure and a selected parking space of the structure. A vehicle transfer mechanism is carried on the platform and includes four self-powered tractors carrying lift arms that can be driven off the platform to engage the tires of a vehicle and to transfer that vehicle onto the platform for transportation between a transfer room and a parking space. The tractors, when deployed, pass outside the vehicle tires with the lift arms folded and can then be operated to extend the arms in a way that engages the tires and lifts the vehicle.

Abstract: A device for thermal cycling a plurality of samples, the device including a chamber for housing a plurality of sample containers, the chamber having a selectively openable port, wherein one or more selected sample containers can be introduced to or withdrawn from the chamber through the port during thermal cycling.

Abstract: The present invention is directed at isoamyl nitrite formulations suitable for use in medicinal applications. The formulations include a composition of isoamyl nitrite in combination with an epoxidized vegetable oil, identified as stabilized isoamyl nitrite. The isoamyl nitrite may also be combined with petrolatum. Methods of treatment of the formulations are applicable to cyanide poisoning, H2S poisoning as well as treatment for elevated blood pressure.

Abstract: The invention relates to a method for the amplification of DNA and apparatus for such amplification. The method comprises steps typically found in amplification methods but utilizes an optical procedure to detect denaturation of DNA or attainment of the desired denaturation temperature. The apparatus (1) comprises a temperature controllable chamber (2) including a rotor (3) for holding a plurality of reaction vessels (see 7 for example) for reaction mixtures including DNA, a drive means for the rotor, a heater (8) within the chamber for transiently supplying infrared energy to the reaction vessels, and an optical system (12-16) for determining denaturation of at least a reference DNA or for detecting attainment of a desired denaturation temperature in at least a reference reaction vessel.

Abstract: The present invention as disclosed herein is an improved vehicle parking structure and method for using the same. The vehicle parking structure provides for the automated storage and retrieval of vehicles in response to user inputs. In one aspect, the vehicle parking structure comprises one or more transfer rooms in which a vehicle operator may deposit and later retrieve a vehicle, a plurality of parking spaces of either fixed or variable dimensions, and one or more vehicle transporters used to move vehicles from the one or more transfer rooms to the plurality of parking spaces. The one or more vehicle transporters are in turn each preferably comprised of one or more vertical stabilizers, one or more tractors, one or more lifts, a lifting platform, and a dolly. The vehicle transporters move the lifting platform and dolly so that the dolly may be positioned to access a vehicle located in a transfer room or parking space.

Abstract: The present invention is directed at isoamyl nitrite formulations suitable for use in medicinal applications. The formulations include a composition of isoamyl nitrite in combination with an epoxidized vegetable oil, identified as stabilized isoamyl nitrite. The isoamyl nitrite may also be combined with petrolatum. Methods of treatment of the formulations are applicable to cyanide poisoning, H2S poisoning as well as treatment for elevated blood pressure.

Abstract: A materials handling vehicle automatically implements steer maneuvers when objects enter an environment around the vehicle. A steer correction maneuver is automatically performed by steering the vehicle away from the detected object, wherein an angle of steer correction and/or a rate of change of the steering angle that is implemented to achieve a desired angle of steer correction is dependent upon how far from a reference coordinate associated with the vehicle the detected object is determined to be.

Abstract: A mechanism for moving vehicles within a vehicle parking structure comprises a lift platform which can be moved vertically and laterally to positions in register with one or more transfer rooms through which vehicles enter and leave the structure and a selected parking space of the structure. A vehicle transfer mechanism is carried on the platform and includes four self-powered tractors carrying lift arms that can be driven off the platform to engage the tires of a vehicle and to transfer that vehicle onto the platform for transportation between a transfer room and a parking space. The tractors, when deployed, pass outside the vehicle tires with the lift arms folded and can then be operated to extend the arms in a way that engages the tires and lifts the vehicle.

Abstract: The invention relates to a device for performing binding assays. In particular, the invention relates to a centrifugal device for performing such assays. The invention also relates to a method of performing binding assays involving antigen-antibody binding, nucleic acid hybridization, or receptor-ligand interaction.

Abstract: A materials handling vehicle is provided comprising: a frame comprising an operator's compartment; wheels supported on the frame, at least one of the wheels being a steerable wheel; a steer-by-wire system associated with the steerable wheel to effect angular movement of the steerable wheel about a first axis; and a control apparatus. The steer-by-wire system comprises a control handle capable of being moved by an operator to generate a steer control signal, a selection switch capable of generating one of a first select signal and a second select signal, and a steer motor coupled to the steerable wheel to effect angular movement of the steerable wheel about the first axis. The control apparatus may be coupled to the control handle to receive the steer control signal, coupled to the selection switch to receive the one select signal, and coupled to the steer motor to generate a first drive signal to the steer motor to effect angular movement of the steerable wheel about the first axis.

Abstract: A materials handling vehicle automatically implements steer maneuvers when objects enter an environment around the vehicle. A steer correction maneuver is automatically performed by steering the vehicle away from the detected object, wherein an angle of steer correction and/or a rate of change of the steering angle that is implemented to achieve a desired angle of steer correction is dependent upon how far from a reference coordinate associated with the vehicle the detected object is determined to be.