Abstract: Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.

Abstract: Human RAB genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of RAB are provided.

Abstract: A rugged, long lasting, transparent housing of a domed shape protects an embedded solar panel. More particularly, the solar panel is embedded in a polymer in a utilized, potted construction. The use of polyurethane as the polymer produces a durable product which is transparent and resistant to both thermal and mechanical stresses. The domed top over the solar panel improves the solar panel's ability to capture light and thus to operate in locations where the incidence of light is at a low angle as is found in northern latitudes.

Abstract: A secoisolanciresinol dehydrogenase protein has been isolated from Forsythia intermedia, together with cDNAs encoding secoisolariciresinol dehydrogenase from this species. Accordingly, isolated DNA sequences are provided which code for the expression of secoisolariciresinol dehydrogenase. In other aspects, the present invention is directed to replicable recombinant cloning vehicles comprising a nucleic acid sequence which codes for a secoisolariciresinol dehydrogenase protein, or to a base sequence sufficiently complementary to at least a portion of a secoisolariciresinol dehydrogenase DNA or RNA to enable hybridization therewith.

Abstract: Human MBCAT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of MBCAT are provided.

Abstract: Human TAOJIK genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TAOJIK are provided.

Abstract: Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.

Abstract: A new hand held drill press for enabling a power hand drill to be converted into a drill press. The inventive device includes a hollow cylindrical sleeve having an open upper end, an open lower end and a cylindrical side wall therebetween. An interior of the cylindrical side wall has an inwardly extending cylindrical wall disposed on a lower half portion thereof. The open lower end of the sleeve has an annular recess formed on an interior surface thereof. A cylindrical drill engagement collar is provided. The cylindrical drill engagement collar is dimensioned for coupling with a nose of a hand held drill. The collar is slidably received within the open upper end of the hollow cylindrical sleeve. A spring member is disposed interiorly of an upper half portion of the cylindrical side wall of the hollow cylindrical sleeve. The spring member has a lower portion secured to an upper end of the inwardly extending cylindrical wall.

Abstract: This invention relates to a new and improved windshield assembly for use with a conventional child safety car seat in a motor vehicle with an open top. The invention also relates to a means of securing the windshield to the child safety car seat using its existing automobile safety belt attachment slots. The object of the invention is to protect the child from harsh direct wind, pebbles, insects and exposure to excessive sunlight while the child is riding in a motor vehicle with an open top. The windshield envisioned is made of a rigid transparent photosensitive material which either changes sun screening characteristics in response to a change in light intensity or is composed of transparent tinted plastic which decreases or otherwise filters incident light. The windshield is designed to allow the child to enjoy the view by enabling him or her to see clearly through the device and likewise to enable adults to see the child.