Abstract: The present invention relates, in part, to methods for large-scale purification of mRNA. The method includes, at least, steps of forming an mRNA slurry, stirring the slurry, and vacuum or pressure filtering the slurry.

Abstract: A method for removing one or more objects or materials from a body lumen includes delivering a tube and an expandable device to the body lumen to a position proximal to the one or more objects or materials. The expandable device is positioned with a lumen of the tube, and the expandable device includes a lumen extending from a distal portion to a proximal portion. The method further includes proximally retracting the tube such that the expandable device remains in the position proximal to the one or more objects or materials, distally advancing the expandable device such that the distal portion of the expandable device at least partially surrounds the one or more objects or materials, at least partially closing a distal end of the expandable device, and moving the expandable device proximally to remove the expandable device and the one or more objects or materials from the lumen.

Abstract: Disclosed are systems and methods for assisting with procedures involving a subject's joint, such as a joint. Robotic devices move and position the subject to manipulate the joint and sensing devices sense the joint gap. The robotic devices are controlled based on the joint gap. Novel techniques are disclosed for joint gap segmentation, approximating an uncertainty in determination of the varying dimension of the joint gap, and real-time motion analysis of the joint gap size. In some examples, a kinematic model of the patient's anatomy is utilized to provide robotically assisted manipulation of the same using the techniques described herein.

Abstract: The present disclosure provides a tissue debridement device and describes an example treatment for ANP using the tissue debridement device. The tissue debridement device has a sheath, a distal tip, and a plurality of rotating tines coupled to the distal tip and the sheath. The distal tip can be adjusted to be closer or further from the sheath to change a diameter of the rotating tines, thereby changing a cutting diameter of the tissue debridement device.

Abstract: The present invention provides compositions comprising a recombinant AAV and one or more pharmaceutically acceptable excipients. The compositions have improved stability and shelf life as compared to other AAV compositions.

Abstract: A cannulation device is adapted to gain access to the patient's common bile duct. In some instances, the cannulation device includes a first guidewire lumen extending through an elongate shaft and terminating at a first oblique guidewire port, and a second guidewire lumen extending through the elongate shaft and terminating at a second oblique guidewire port. In some instances, the cannulation device includes an inflatable balloon that is inflatable from a collapsed configuration to an expanded configuration in which the inflatable balloon is adapted to occlude the patient's pancreatic duct. In some instances, the cannulation device includes an expandable element that is expandable from a collapsed configuration in which the expandable element is disposed within the guidewire lumen and an extended configuration in which a portion of the expandable element extends distally from a guidewire port.

Abstract: Embodiments described herein are generally directed to a containerized application software deployment architecture. According to an example, a system includes multiple hosts that are part of aa stretch cluster spanning multiple data centers. Each of the hosts include a processing resource, a memory, and a storage device. Each host of a first subset of the multiple hosts runs multiple containerized instances of a component of a Security Information and Event Management (SIEM) application within respective containers. At least one host of the multiple hosts is separate from the first subset and is dedicated to running at least one containerized ingress gateway application operable to load balance requests directed to the SIEM application among the multiple containerized instances running on the first subset of hosts.

Abstract: Embodiments described herein are generally directed to a containerized application software deployment architecture. According to an example, a system includes multiple hosts that are part of aa stretch cluster spanning multiple data centers. Each of the hosts include a processing resource, a memory, and a storage device. Each host of a first subset of the multiple hosts runs multiple containerized instances of a component of a Security Information and Event Management (SIEM) application within respective containers. At least one host of the multiple hosts is separate from the first subset and is dedicated to running at least one containerized ingress gateway application operable to load balance requests directed to the SIEM application among the multiple containerized instances running on the first subset of hosts.

Abstract: Systems and methods for real time connection of service seekers with online service providers are disclosed. The system includes a server configured to establish presence lists corresponding to subject matter and generating live lists of service providers associated with the subject matter. The server is further configured to allow users to select a service provider from the live list and establish a live media session between the user and the service provider in which the service provider is removed from the live list upon selection resulting in remaining service providers ascending the live list in real-time.

Abstract: Embodiments described herein are generally directed to a containerized application software deployment architecture. According to an example, a system includes multiple hosts that are part of aa stretch cluster spanning multiple data centers. Each of the hosts include a processing resource, a memory, and a storage device. Each host of a first subset of the multiple hosts runs multiple containerized instances of a component of a Security Information and Event Management (SIEM) application within respective containers. At least one host of the multiple hosts is separate from the first subset and is dedicated to running at least one containerized ingress gateway application operable to load balance requests directed to the SIEM application among the multiple containerized instances running on the first subset of hosts.

Abstract: A method for sweeping an electromagnetic radiation source (12) to produce single mode operation having an optimized side-mode suppression ratio over a continuous range of wavelengths within a prescribed temporal profile, the electromagnetic radiation source is configured to output electromagnetic radiation at a given wavelength based upon parameters. The method includes determining a set of parameter combinations that satisfy a condition for a desired set of wavelengths and a maximum side mode suppression ratio over the range of wavelengths. The set of parameter combinations define sub-paths for transitioning from one wavelength to another wavelength. Combinations of select sub-paths provide a multivariate path for transitioning over the range of wavelengths. The method also includes controlling the semiconductor laser to emit electromagnetic radiation over the range of wavelengths by traversing the multivariate path in a desired manner.

Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Abstract: Systems and methods including one or more processing modules and one or more non-transitory storage modules storing computing instructions configured to run on the one or more processing modules and perform acts of coordinating displaying a set of dress code interface elements, coordinating displaying each weather condition interface element of the set of weather condition interface elements associated with a different weather condition of a set of weather conditions, receiving a dress code selection of a first dress code interface element of the set of dress code interface elements, receiving a weather condition selection of a first weather condition interface element of the set of weather condition interface elements, and coordinating displaying a first outfit comprising multiple layers. The one item for each layer of the multiple layers can be based on one or more item affinity scores for the user and one or more color rules.

Abstract: The toothbrush handle loop is a loop attached to the handle of a toothbrush which enables the toothbrush to be hung perpendicular to the ground in open air, toothbrush handle up and toothbrush head down. The toothbrush handle loop also allows identifying features selected by the toothbrush user to be added to the loop for identification or ornamentation.

Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Abstract: A method for sweeping an electromagnetic radiation source (12) to produce single mode operation having an optimized side-mode suppression ratio over a continuous range of wavelengths within a prescribed temporal profile, the electromagnetic radiation source is configured to output electromagnetic radiation at a given wavelength based upon parameters. The method includes determining a set of parameter combinations that satisfy a condition for a desired set of wavelengths and a maximum side mode suppression ratio over the range of wavelengths. The set of parameter combinations define sub-paths for transitioning from one wavelength to another wavelength. Combinations of select sub-paths provide a multivariate path for transitioning over the range of wavelengths. The method also includes controlling the semiconductor laser to emit electromagnetic radiation over the range of wavelengths by traversing the multivariate path in a desired manner.

Abstract: Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

Abstract: Systems and methods including one or more processing modules and one or more non-transitory storage modules storing computing instructions configured to run on the one or more processing modules and perform acts of coordinating displaying a set of dress code interface elements, coordinating displaying each weather condition interface element of the set of weather condition interface elements associated with a different weather condition of a set of weather conditions, receiving a dress code selection of a first dress code interface element of the set of dress code interface elements, receiving a weather condition selection of a first weather condition interface element of the set of weather condition interface elements, and coordinating displaying a first outfit comprising multiple layers. The one item for each layer of the multiple layers can be based on one or more item affinity scores for the user and one or more color rules.

Abstract: A hanger wire tool is provided. The hanger wire tool includes an elongated plate. The elongated plate includes a front surface, a rear surface, a first end and a second end opposite the first end. An aperture is formed through the top and bottom surface at the first end. At least one magnet is secured to the second end. A plurality of calibrated lines operable to measure distances are disposed on the front surface at the second end of the elongated plate.