Abstract: A method of making a transgenic fusion protein. The method inlcudes providing a transgenic animal which includes a transgene which provides for the expression of the fusion protein; allowing the transgene to be expressed; and, recovering the fusion protein, from the milk of the transgenic animal.

Abstract: Processes for the preparation of biotinylated polynucleotides and analogues thereof and protected intermediate products for use in such processes are described and claimed. The processes may be conveniently used in the automated synthesis of biotinylated polynucleotide on a DNA synthesizer. The polynucleotides so prepared may be used as labelled probes e.g. as diagnostic tools for clinical and research uses.

Abstract: The invention concerns novel 2-[4-(4-chlorophenyl)benzyloxy]acetic acids of the formula: ##STR1## in which R.sup.1 is hydrogen or (1-4C)alkyl, R.sup.2 is phenyl optionally bearing a halogeno substituent, and R.sup.3 is hydrogen or (1-4C)alkyl, and when R.sup.3 is hydrogen pharmaceutically acceptable base-addition salts thereof; and processes for their manufacture.The compounds possess useful anti-arthritic properties coupled with desirable pharmacokinetic properties and the minimum of adverse properties, and the invention also concerns pharmaceutical compositions of such compounds for use in the treatment of arthritic joint diseases. A typical compound of the invention is 2-[4-(4-chlorophenyl)benzyloxy]-2-phenyl propionic acid.

Abstract: The invention concerns novel hydroxyalkanoic acid derivatives of the formula: ##STR1## in which A is a straight or branched chain (2-6C)alkylene, R.sup.1 and R.sup.2 are independently hydrogen or (1-6C) alkyl, and R.sup.3 is hydrogen or (1-6C)alkyl, and when R.sup.3 is hydrogen, base-addition salts thereof; and processes for their manufacture.The compounds possess useful anti-arthritic properties and the invention also concerns pharmaceutical compositions of such compounds for use in the treatment of arthritic joint diseases. A representative compound of the invention is 2-{2-[4-(4-chlorophenyl)phenyl]-ethoxy}propionic acid.

Abstract: A novel class of intermediates from which a variety of uronic acid nucleosides can be produced, said class being represented by the following formula: ##SPC1##WhereR.sub.1 and R.sub.2 are lower alkyl radicals having one to six carbon atoms, or phenyl radicals;R.sub.3 is a lower alkyl radical having one to four carbon atoms; and the wavy line at the 5' position indicates both the 5'-D-allo and 5'-L-talo epimers.A process for producing these intermediates is described. A process for converting these intermediates to uronic acid nucleosides having the following formula: ##SPC2##WhereB is a pyrimidine or purine base, is also described.Novel uronic acid nucleosides, having structures falling within the general formula given above, are identified.