Abstract: This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.

Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

Abstract: Methods of machining a single piece hub with integral upper and lower female cones includes providing a single piece hub with upper and lower conical voids having respective narrow ends proximal each other and respective wide ends distal each other. Surfaces of the voids are machined using a tool provided from a single side of the hub that is dimensioned to fit through an opening defined by the interface between the narrow ends of the conical void. The tool can be moved parallel to a rotational axis for accessing conical surfaces of both voids and perpendicular to the rotational axis while contacting the surfaces so as to produce a final machined surface.

Abstract: To simplify fabrication of an integral hub piece, the opening between the upper and lower female cones in this hub has sufficient width or radial dimension to allow access to both cones from one side of the hub with the cutting tool. A cutting tool is used which has a width smaller than the opening between the cones. Preferably, the tool has a width which is about equal to or smaller than an angular dimension through this opening which is defined by extending surfaces of the upper and lower female cones. If this limitation is satisfied, both cones can be created with a single machine set up operating from one side of the integrated hub. Preferably the tool should only move orthogonal or parallel to the cutting tools rotational center axis.

Abstract: An active fluid bearing system is provided. In one example, the active fluid bearing system includes an interface region formed between an outer surface of an inner member and an opposing inner surface of an outer member. The inner and outer members are disposed for relative rotation of the inner and outer members, and thereby form an interface region having a hydrodynamic bearing region and an active bearing region. A liquid is disposed in the interface region at the hydrodynamic bearing region, and is further disposed in the active bearing region if the inner and outer members are not relatively rotating. The bearing system is operable for evacuating at least a portion of the liquid from the active bearing region during relative rotation of the inner and outer members. The active bearing region may be a journal bearing or a thrust bearing.

Abstract: To simplify fabrication of an integral hub piece, the opening between the upper and lower female cones in this hub has sufficient width or radial dimension to allow access to both cones from one side of the hub with the cutting tool. A cutting tool is used which has a width smaller than the opening between the cones. Preferably, the tool has a width which is about equal to or smaller than an angular dimension through this opening which is defined by extending surfaces of the upper and lower female cones. If this limitation is satisfied, both cones can be created with a single machine set up operating from one side of the integrated hub.

Abstract: A section mill is positioned below an exit guide in a drill string assembly used to mill a section of steel casing below the whipstock and which as the section mill moves down and mills along the section of casing, causes the whipstock to be lowered down adjacent the milled-out casing and allows the drill bit and drill string to be run along the surface of the exit guide and into the earth formation. Alternatively, the section mill is positioned above the exit guide in a drill string assembly after the section mill has milled out in an appropriate length of the steel casing, the tubing string pulls both the section mill and the exit guide up to a position where the exit guide is adjacent the area of formation which has been exposed by milling along the steel casing.

Abstract: A conical hydrodynamic bearing gauging and seating system that enables the efficient seating of conical hydrodynamic bearings to a rotor shaft and hub while the rotor assembly remains in a pressing fixture. The invention provides a conical hydrodynamic bearing gauging and seating apparatus comprising a capacitive probe assembly disposed within a hollow pressing fixture in communication with a rotor shaft.

Abstract: A bearing system in which an axially stiff narrow gap fluid dynamic gas bearing is preloaded by an axially less stiff larger gap fluid dynamic bearing. As an example two fluid dynamic bearings are provided spaced apart along a shaft, one of the bearings comprising a fluid dynamic bearing, the other comprising an air bearing. The fluid dynamic bearing has a larger gap, while the air bearing has a relatively small gap. The overall working surface area of the air bearing may be twice as much or more than the working surface area of the fluid bearing.

Abstract: To simplify fabrication of an integral hub piece, the opening between the upper and lower female cones in this hub has sufficient width or radial dimension to allow access to both cones from one side of the hub with the cutting tool. A cutting tool is used which has a width smaller than the opening between the cones. Preferably, the tool has a width which is about equal to or smaller than an angular dimension through this opening which is defined by extending surfaces of the upper and lower female cones. If this limitation is satisfied, both cones can be created with a single machine set up operating from one side of the integrated hub.

Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

Abstract: To simplify fabrication of an integral hub piece, the opening between the upper and lower female cones in this hub has sufficient width or radial dimension to allow access to both cones from one side of the hub with the cutting tool. A cutting tool is used which has a width smaller than the opening between the cones. Preferably, the tool has a width which is about equal to or smaller than an angular dimension through this opening which is defined by extending surfaces of the upper and lower female cones. If this limitation is satisfied, both cones can be created with a single machine set up operating from one side of the integrated hub. Preferably the tool should only move orthogonal or parallel to the cutting tools rotational center axis.

Abstract: A method of differentiating tumors from healthy cells in tissue is disclosed. The method includes the steps of providing a marker-folate conjugate, placing the marker-folate conjugate in contact with the tissue and viewing the tissue.

Abstract: A bearing system in which an axially stiff narrow gap fluid dynamic gas bearing is preloaded by an axially less stiff larger gap fluid dynamic bearing. As an example two fluid dynamic bearings are provided spaced apart along a shaft, one of the bearings comprising a fluid dynamic bearing, the other comprising an air bearing. The fluid dynamic bearing has a larger gap, while the air bearing has a relatively small gap. The overall working surface area of the air bearing may be twice as much or more than the working surface area of the fluid bearing.

Abstract: A section mill is positioned below a whipstock or other exit guide in a drill string assembly used to mill a section of steel casing below the whipstock and which as the section mill moves down and mills along the section of casing, causes the whipstock to be lowered down adjacent the milled-out casing and allows the drill bit and drill string to be run along the surface of the whipstock and into the earth formation. In an alternative embodiment, the combination of having the section mill below the whipstock is used in open hole operations having no casing. In yet another alternative embodiment, the section mill is positioned above the whipstock or other exit guide in a drill string assembly after the section mill has milled out in an appropriate length of the steel casing, the tubing string pulls both the section mill and the whipstock or other exit guide up to a position where the exit guide is adjacent the area of formation which has been exposed by milling along the steel casing.

Abstract: A combined casing mill and whipstock or other exit guide is positioned in a drill string assembly used to mill a section of steel casing, which as the section mill mills along the section of casing, allows the exit guide to be transported adjacent the milled-out casing and allows a drill bit and drill string to be run along the surface of the exit guide and into the earth formation. In an alternative embodiment, the combination of the section mill with the exit guide is used in open hole operations having no casing.

Abstract: To simplify fabrication of an integral hub piece, the opening between the upper and lower female cones in this hub has sufficient width or radial dimension to allow access to both cones from one side of the hub with the cutting tool. A cutting tool is used which has a width smaller than the opening between the cones. Preferably, the tool has a width which is about equal to or smaller than an angular dimension through this opening which is defined by extending surfaces of the upper and lower female cones. If this limitation is satisfied, both cones can be created with a single machine set up operating from one side of the integrated hub.