Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Described herein are compositions and methods that utilize complementary polymerization reactions to simultaneously generate one or more polymeric materials, including crosslinked polymer matrices, tethered inter-penetrating network, heterogenous polymer blends, or homogeneous polymer blends. The provided compositions and methods utilize the combination of an energy demanding step-growth reaction with a highly exothermic reaction to drive the energy demanding reaction by chemical heating and avoid issues associated with thermal runaway, such as solution boiling or unwanted biproducts.

Abstract: A method of performing brain surgery on a patient having a skull and brain tissue, that starts by creating an opening, having a rim, in the skull. The method uses an assembly for facilitating brain surgery that includes a curved frame, defining an inward dimension and an outward dimension; a plurality of spatula arm subassemblies, each including a spatula arm frame clamp, releasably attached to the frame, a spatula arm held and supported by the spatula arm frame clamp and a spatula extending from the inward end of the spatula arm of the spatula arm subassembly. The assembly is clamped to the rim and the spatula arms are positioned so that the spatulas engage the brain tissue in a manner that facilitates surgery.

Abstract: A closed loop extraction system for extracting desired components from raw plant matter and method of use is disclosed. The closed loop extraction system features a solvent source, a chill tank, a wash tank, a rinse tank, a centrifuge, and a feed tank all in fluid communication via a series of interconnected pump systems. The method of extracting the desired products from raw plant matter uses this system to perform the extraction with a reduced amount of solvent in an energy-efficient manner.

Abstract: A closed loop extraction system for extracting desired components from raw plant matter and method of use is disclosed. The closed loop extraction system features a solvent source, a chill tank, a wash tank, a rinse tank, a centrifuge, and a feed tank all in fluid communication via a series of interconnected pump systems. The method of extracting the desired products from raw plant matter uses this system to perform the extraction with a reduced amount of solvent in an energy-efficient manner.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: A closed loop extraction system for extracting desired components from raw plant matter and method of use is disclosed. The closed loop extraction system features a solvent source, a chill tank, a wash tank, a rinse tank, a centrifuge, and a feed tank all in fluid communication via a series of interconnected pump systems. The method of extracting the desired products from raw plant matter uses this system to perform the extraction with a reduced amount of solvent in an energy-efficient manner.

Abstract: An assembly for facilitating brain surgery performed through an opening having a rim, created in the skull of a patient and having a curved frame, defining an inward dimension and an outward dimension. Also, at least one clamp arm subassembly is attached to the frame, and has a clamp arm frame clamp, releasably attached to the frame; a clamp arm having a longitudinal dimension, releasably held and supported by the clamp arm frame clamp, and adjustable relative to the frame clamp along the longitudinal dimension; and a skull clamp, supported by the arm, and adapted to clamp onto the rim. Further included is at least one spatula arm subassembly, which has a spatula arm frame clamp, releasably attached to the frame; a spatula arm held and supported by the spatula arm frame clamp; and a spatula extending from the inward end of the spatula arm of the spatula arm subassembly.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: A method of performing brain surgery on a patient having a skull and brain tissue, that starts by creating an opening, having a rim, in the skull. The method uses an assembly for facilitating brain surgery that includes a curved frame, defining an inward dimension and an outward dimension; a plurality of spatula arm subassemblies, each including a spatula arm frame clamp, releasably attached to the frame, a spatula arm held and supported by the spatula arm frame clamp and a spatula extending from the inward end of the spatula arm of the spatula arm subassembly. The assembly is clamped to the rim and the spatula arms are positioned so that the spatulas engage the brain tissue in a manner that facilitates surgery.

Abstract: An assembly for facilitating brain surgery performed through an opening having a rim, created in the skull of a patient and having a curved frame, defining an inward dimension and an outward dimension. Also, at least one clamp arm subassembly is attached to the frame, and has a clamp arm frame clamp, releasably attached to the frame; a clamp arm having a longitudinal dimension, releasably held and supported by the clamp arm frame clamp, and adjustable relative to the frame clamp along the longitudinal dimension; and a skull clamp, supported by the arm, and adapted to clamp onto the rim. Further included is at least one spatula arm subassembly, which has a spatula arm frame clamp, releasably attached to the frame; a spatula arm held and supported by the spatula arm frame clamp; and a spatula extending from the inward end of the spatula arm of the spatula arm subassembly.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: A liquid separator and concentrator is disclosed. An example liquid separator and concentrator includes a separator column. A spray chamber has a sprayer nozzle to spray an influent within the spray chamber and create a falling film in the separator column. A heating jacket surrounds the separator column, wherein the heating jacket heats the falling film to evaporate at least one portion of the falling film and leaves a concentrate. A concentrate collection vessel receives the concentrate from the separator column.

Abstract: The invention provides a variety of molecular tools for use in live-cell tracking of activities of biomolecules and in high-throughput drug screening.

Abstract: Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds.

Abstract: The invention provides a variety of molecular tools for use in live-cell tracking of activities of biomolecules and in high-throughput drug screening.

Abstract: Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially therapeutic compounds.