Abstract: Devices used to provide access the vasculature are disclosed. The devices may be configured to provide access to a blood vessel, such as an artery. The devices may include a catheter assembly disposed over a needle assembly. The devices may also include a barrel assembly coupled to the needle assembly. A guidewire may be displaceable by barrel assembly within a needle. The needle may include a proximal and distal port.

Abstract: Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured to displace fluid in order to inflate or deflate a medical device, such as a balloon. The devices further include features and mechanisms for limiting pressure generation so as to avoid damage due to overpressurization.

Abstract: Devices, systems, kits, and methods used to collect drainage fluid from a patient are disclosed. The systems or kits include a multi-port manifold, and one or more drainage tubes to fluidly connect vacuum drainage bottles with the multi-port manifold. One or more vacuum drainage bottles can also be included in the kit as desired. The method of drainage fluid collection can include filling two vacuum drainage bottles simultaneously with drainage fluid, then filling a third vacuum drainage bottle with drainage fluid, and then filling a fourth vacuum drainage bottle with drainage fluid.

Abstract: A device, and methods for using said device, for inserting a marker into a patient's body. The device may comprise a retention mechanism to hold the device in an first, undeployed, state. The device may be inserted into a patient's body in the first state, transitioned by the user into a second state wherein the retention mechanism is overcome, and then transition the device into a third state to deliver a marker to a precise location. The device may then be removed from the patient's body.

Abstract: Inflation devices and methods used to inflate a balloon of a balloon catheter are disclosed. The inflation devices include a pressure member to contain a fluid to be pressurized. The pressure member includes a load transfer orifice configured to receive a load transfer member of a threaded insert. The load transfer member can transfer an axial load applied to the threaded insert during pressurization of the fluid to the pressure member. A plunger including a thread rail is slidingly disposed within the pressure member. The thread rail is engaged with the threaded insert when the fluid is pressurized. An actuator disengages the thread rail from the threaded insert to depressurize the fluid.

Abstract: A device, and related systems and methods, for inserting a marker into a patient's body. The device may comprise a retention mechanism to hold the device in a first, undeployed, state. The device may be inserted into a patient's body in the first state, transitioned by the user into a second state wherein the retention mechanism is overcome, and then transition the device into a third state to deliver a marker to a precise location. The device may then be removed from the patient's body.

Abstract: Devices used to drain fluid are disclosed. The devices may be configured to drain fluid from a body cavity using a vacuum pressure. The devices include a reservoir and a vacuum generating member configured to expand the reservoir and generate a vacuum pressure within the reservoir. The devices can be configured to be shipped in a collapsed state.

Abstract: A syringe assembly void of silicone is disclosed. The syringe assembly includes a syringe plunger and a syringe barrel. The syringe plunger includes a handle and a plunger tip. The plunger tip includes a wiper extending from a hinge configured to allow the wiper to flex proximally and distally. The wiper includes a proximal circumferential seal and a distal circumferential seal. The proximal circumferential seal is configured to seal against an internal surface of the syringe barrel when the syringe plunger is displaced proximally and a negative pressure is generated within the syringe barrel. The distal circumferential seal is configured to seal against the internal surface of the syringe barrel when the syringe plunger is displaced distally and a positive pressure is generated within the syringe barrel. The syringe barrel includes internal detents to retain the syringe plunger within the syringe barrel.

Abstract: Devices, systems, and methods used to drain a body cavity under a vacuum are disclosed. The devices include a vacuum container, a cap, and a vacuum indicator. The vacuum indicator is configured to indicate a vacuum status of the container. The vacuum indicator includes one or more of an expandable member, a flexible membrane, a linear pressure gauge, a digital pressure gauge, a retractable member, a vacuum gauge, a displaceable seal member, a deflectable membrane, or a deflectable member.

Abstract: Hemostasis valve devices and methods of use are disclosed. The hemostasis valve devices include a body member, a slide member, an introducer member, a valve cap, and a valve member. The body member and slide member can be gripped by a user's finger and thumb, respectively. The slide member can be distally displaced by the user's thumb to distally displace the introducer member through the valve member to open the valve member to allow passage of a medical appliance through the valve member. The introducer member can be selectively locked in a distal position to keep the valve open.

Abstract: Devices and materials are disclosed for collecting breath samples and for testing such samples for the presence of a pathogen, for example the pathogen(s) associated with Coronavirus Disease 2019 (COVID-19). In some embodiments, a collection device can include a tube into which a subject can exhale or cough, and that provides for use of a filter to capture expired sample material. In some embodiments, a sample liquid can be created from the breath sample by addition of an indicator to render a pathogen in the sample readily detectable. In some embodiments, materials are provided for an assay to detect a pathogen in the sample liquid.

Abstract: Devices and methods used collect and transport a biological specimen are disclosed. The devices include a vial defining a specimen chamber to retain a specimen, a collection member to collect a specimen, and a cap containing a liquid medium to treat the specimen for transport. The cap includes a puncture member to puncture a seal to release the liquid medium from the cap.

Abstract: Devices, systems, and methods used to drain a body cavity under a vacuum are disclosed. The devices include a vacuum container and a cap. The container includes an ergonomic gripping portion to allow a user to easily handle the container in use. The cap includes a sealing member configured to selectively seal an inlet to control the flow of drainage fluid into the vacuum container.

Abstract: Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured to displace fluid in order to inflate or deflate a medical device, such as a balloon. The devices include a trigger configured to convert the devices from a pressurization state to a priming state. The devices further include a locking or toggle member configured to toggle and/or maintain the devices in a priming state.

Abstract: Devices used to provide access the vasculature are disclosed. The devices may be configured to provide access to a blood vessel, such as an artery. The devices may include a catheter assembly disposed over a needle assembly. The devices may also include a barrel assembly coupled to the needle assembly. A guidewire may be displaceable by barrel assembly within a needle. The needle may include a proximal and distal port.

Abstract: An inflation device including a handle mechanism configured to selectively engage and disengage threads within the device. In some instances, the threads are configured to couple a plunger to a syringe body. The handle mechanism may be configured to (1) provide a mechanical advantage and (2) change the location and direction of the input force.

Abstract: Devices used to drain fluid are disclosed. The devices may be configured to drain fluid from a body cavity using a vacuum pressure. The devices include a reservoir and a vacuum generating member configured to expand the reservoir and generate a vacuum pressure within the reservoir. The devices can be configured to be shipped in a collapsed state.