Abstract: The present invention concerns the field of diagnostics and patient stratification for cancer therapy. In particular, it relates to a method for assessing a treatment response associated with immunotherapy in a subject in need thereof comprising the steps of determining hepatic auto-aggressive CD8 positive (+) PD-1 positive (+) T cells exhibiting traits of activation and exhaustion or CD8+ T cell precursors thereof in a sample of a subject in need of immunotherapy or in a data set comprising imaging data of a subject in need of immunotherapy, and assessing the treatment response associated with immunotherapy based on the presence, absence or abundance of said hepatic auto-aggressive CD8+ PD-1+ T-cells exhibiting traits of activation or exhaustion or CD8+ T cell precursors thereof. Further contemplated is a method for recommending immunotherapy for a subject or a method for treating a subject by immunotherapy.

Abstract: A system includes a multicore chip configured to perform machine learning (ML) operations. The system also includes a power monitoring module configured to measure power consumption of the multicore chip on a main power rail of the multicore chip. The power monitoring module is further configured to assert a signal in response to the measured power consumption exceeding a first threshold. The power monitoring module is further configured to transmit the asserted signal to a power throttling module to initiate a power throttling for the multicore chip.

Abstract: A system includes a multicore chip configured to perform machine learning (ML) operations. The system also includes a power monitoring module configured to measure power consumption of the multicore chip on a main power rail of the multicore chip. The power monitoring module is further configured to assert a signal in response to the measured power consumption exceeding a first threshold. The power monitoring module is further configured to transmit the asserted signal to a power throttling module to initiate a power throttling for the multicore chip.

Abstract: Techniques of controlling access to one or more functions on a computing device. Aspects of the technique include accepting designation of the one or more functions and requiring completion of one or more educational tasks to permit access to the one or more functions. The functions may include playing a game, accessing social media, or the like. Certain functions, such as making an emergency (e.g., 911) call, may be excluded from being affected by the technique. Also, systems including at least one tangible computing element that perform such techniques.

Abstract: In an exemplary embodiment of the present invention, an optical interface unit provides an interface between an optoelectronic device and industry standard MTP/MPO connectors. The optical interface unit axially aligns the core of a fiber with the optoelectronic device and interfaces that fiber to the standardized connector. In addition, the optical interface unit further provides a standardized interface for visible contact connection between the individual fiber stubs and the terminated fibers in the standardized connector. The optical interface unit therefore maximizes coupling from the optoelectronic device with the standardized connector.

Abstract: A method and apparatus for driving lasers. An example laser driving system includes a laser current controller for providing a modulation signal and a bias signal. The modulation signal and bias signal is used by a plurality of high-speed current drivers that accept the modulation signal and the bias signal and produce a plurality of laser drive signals. The example system also has a disable input that disconnects power from a high-speed current driver when the high-speed current driver is not in use. The exemplary system develops the modulation and bias signals by feeding back a signal developed from detection of laser light from one of the lasers driven by the system. The laser may be a data laser or a control laser that is modulated by a signal having a lower frequency than the data lasers. If a control laser is used then the photodetector circuit used for feedback can have a lower frequency response because of the lower frequency of the control laser signal.

Abstract: In an exemplary embodiment of the present invention, an optical interface unit provides an interface between an optoelectronic device and industry standard MTP/MPO connectors. The optical interface unit axially aligns the core of a fiber with the optoelectronic device and interfaces that fiber to the standardized connector. In addition, the optical interface unit further provides a standardized interface for visible contact connection between the individual fiber stubs and the terminated fibers in the standardized connector. The optical interface unit therefore maximizes coupling from the optoelectronic device with the standardized connector.

Abstract: In an exemplary embodiment of the present invention, an optical interface unit provides an interface between an optoelectronic device and industry standard MTP/MPO connectors. The optical interface unit axially aligns the core of a fiber with the optoelectronic device and interfaces that fiber to the standardized connector. In addition, the optical interface unit further provides a standardized interface for visible contact connection between the individual fiber stubs and the terminated fibers in the standardized connector. The optical interface unit therefore maximizes coupling from the optoelectronic device with the standardized connector.

Abstract: A method and apparatus for driving lasers. An example laser driving system includes a laser current controller for providing a modulation signal and a bias signal. The modulation signal and bias signal is used by a plurality of high-speed current drivers that accept the modulation signal and the bias signal and produce a plurality of laser drive signals. The example system also has a disable input that disconnects power from a high-speed current driver when the high-speed current driver is not in use. The exemplary system develops the modulation and bias signals by feeding back a signal developed from detection of laser light from one of the lasers driven by the system. The laser may be a data laser or a control laser that is modulated by a signal having a lower frequency than the data lasers. If a control laser is used then the photodetector circuit used for feedback can have a lower frequency response because of the lower frequency of the control laser signal.

Abstract: A method and apparatus for driving lasers. An example laser driving system includes a laser current controller for providing a modulation signal and a bias signal. The modulation signal and bias signal is used by a plurality of high-speed current drivers that accept the modulation signal and the bias signal and produce a plurality of laser drive signals. The example system also has a disable input that disconnects power from a high-speed current driver when the high-speed current driver is not in use. The exemplary system develops the modulation and bias signals by feeding back a signal developed from detection of laser light from one of the lasers driven by the system. The laser may be a data laser or a control laser that is modulated by a signal having a lower frequency than the data lasers. If a control laser is used then the photodetector circuit used for feedback can have a lower frequency response because of the lower frequency of the control laser signal.

Abstract: A receiver optical subassembly (ROSA) includes a photodetector array and a transimpedance amplifier (TIA) array. In each data channel, the photodetector is wire bonded to a corresponding input pad of the TIA array. A ground pad is disposed between adjacent input pads and connected to a ground plane via an isolated bonding strip on the photodetector array in order to alleviate crosstalk between the channels. The output data channels of the TIA are tightly spaced at the output pads of the TIA and are fanned out on the ceramic to increase the spacing of the data channels as they extend from the TIA. The ROSA includes the use of embedded capacitance to reduce crosstalk and noise by decoupling reference planes formed within the multilayer ceramic substrate. Input and output ground planes of the TIA are separated in the vicinity of the TIA and coupled on a ceramic layer spaced farther from the TIA, to alleviate crosstalk.

Abstract: An optical communication system that includes a multi-channel post amplifier assembly with flexible output configurations for amplifying optical-to-electrical converted signals on selectable groups of amplifier channels is provided. The post amplifier assembly, when implemented on a single IC chip, is capable of operating with either the 2.5V or 3.3V of power supply. In addition, the IC chip containing the post amplifier assembly provides capability to selectively turn off one or more post amplifier channels during operation. Further, the post amplifiers provide integral auto zero function without requiring a use of external capacitors.

Abstract: A method and apparatus for driving lasers. An example laser driving system includes a laser current controller for providing a modulation signal and a bias signal. The modulation signal and bias signal is used by a plurality of high-speed current drivers that accept the modulation signal and the bias signal and produce a plurality of laser drive signals. The example system also has a disable input that disconnects power from a high-speed current driver when the high-speed current driver is not in use. The exemplary system develops the modulation and bias signals by feeding back a signal developed from detection of laser light from one of the lasers driven by the system. The laser may be a data laser or a control laser that is modulated by a signal having a lower frequency than the data lasers. If a control laser is used then the photodetector circuit used for feedback can have a lower frequency response because of the lower frequency of the control laser signal.

Abstract: A method and apparatus for driving lasers. An example laser driving system includes a laser current controller for providing a modulation signal and a bias signal. The modulation signal and bias signal is used by a plurality of high-speed current drivers that accept the modulation signal and the bias signal and produce a plurality of laser drive signals. The example system also has a disable input that disconnects power from a high-speed current driver when the high-speed current driver is not in use. The exemplary system develops the modulation and bias signals by feeding back a signal developed from detection of laser light from one of the lasers driven by the system. The laser may be a data laser or a control laser that is modulated by a signal having a lower frequency than the data lasers. If a control laser is used then the photodetector circuit used for feedback can have a lower frequency response because of the lower frequency of the control laser signal.

Abstract: In an exemplary embodiment of the present invention, an optical interface unit provides an interface between an optoelectronic device and industry standard MTP/MPO connectors. The optical interface unit axially aligns the core of a fiber with the optoelectronic device and interfaces that fiber to the standardized connector. In addition, the optical interface unit further provides a standardized interface for visible contact connection between the individual fiber stubs and the terminated fibers in the standardized connector. The optical interface unit therefore maximizes coupling from the optoelectronic device with the standardized connector.

Abstract: In an exemplary embodiment of the present invention, an optical interface unit provides an interface between an optoelectronic device and industry standard MTP/MPO connectors. The optical interface unit axially aligns the core of a fiber with the optoelectronic device and interfaces that fiber to the standardized connector. In addition, the optical interface unit further provides a standardized interface for visible contact connection between the individual fiber stubs and the terminated fibers in the standardized connector. The optical interface unit therefore maximizes coupling from the optoelectronic device with the standardized connector.

Abstract: A method and apparatus for coupling light from an array of optoelectronic devices to a corresponding array of fibers contained in a fiber optic ferrule is disclosed. The fibers may be single-mode or multi-mode optical fibers. The method includes fixing the fiber optic ferrule to the optical subassembly (OSA) base upon which the array of optoelectronic devices will be affixed, aligning the array of optoelectronic devices to the corresponding array of fibers, then securing the array of optoelectronic devices to the OSA base. In one embodiment, the module includes an optical subassembly module housing a linear array of 1300 nm VCSELs or photodetectors, spaced apart at a 250 micron pitch to correspond to the spacing of optical fibers in a conventional MT ferrule. The array of optoelectronic devices is mounted on a substrate assembly that includes a weldable surface and one or more photodetectors for automatic power control.

Abstract: A method and apparatus for driving lasers. An example laser driving system includes a laser current controller for providing a modulation signal and a bias signal. The modulation signal and bias signal is used by a plurality of high-speed current drivers that accept the modulation signal and the bias signal and produce a plurality of laser drive signals. The example system also has a disable input that disconnects power from a high-speed current driver when the high-speed current driver is not in use. The exemplary system develops the modulation and bias signals by feeding back a signal developed from detection of laser light from one of the lasers driven by the system. The laser may be a data laser or a control laser that is modulated by a signal having a lower frequency than the data lasers. If a control laser is used then the photodetector circuit used for feedback can have a lower frequency response because of the lower frequency of the control laser signal.

Abstract: An alarm system suitable for use in a telecommunications network in which a central switching system is capable of selectively providing a signal of a predetermined polarity to a plurality of remotely located stations without being dependent upon or impeding the ability of the central switching system to process relatively high volume communications traffic. Each of the remote stations is connected to the telecommunications network by an electrical conduction path. The stations are substantially unresponsive to the predetermined polarity signal. In response to an alarm indication signal, the system effects a reversal in the polarity of the signal provided to a selected subset of the remote stations. Each station in the selected subset responds to the polarity reversal by indicating an alarm condition.