Patents by Inventor Michael E. Buck

Michael E. Buck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation of cellular material under microscopic visualization
    Patent number: 6569639
    Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: May 27, 2003
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
  • Isolation of cellular material under microscopic visualization
    Publication number: 20010031481
    Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
    Type: Application
    Filed: January 18, 2001
    Publication date: October 18, 2001
    Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
  • Isolation of cellular material under microscopic visualization
    Patent number: 6204030
    Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: March 20, 2001
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
  • Isolation of cellular material under microscopic visualization
    Patent number: 6010888
    Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
    Type: Grant
    Filed: September 8, 1997
    Date of Patent: January 4, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Ann Weiss, Zhengping Zhuang, Robert F. Bonner
  • Isolation of cellular material under microscopic visualization
    Patent number: 5843657
    Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: December 1, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Weiss, Zhongping Zhuang