Patents by Inventor Michael E. Lankin

Michael E. Lankin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole and analogs thereof
    Patent number: 5856511
    Abstract: The present invention relates to a practical and facile synthesis of 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) and analogs thereof. The synthesis utilized a novel hydrazinium salt as an intermediate reaction product which facilitates the isolation of purified product in high yields.
    Type: Grant
    Filed: August 6, 1997
    Date of Patent: January 5, 1999
    Assignee: Alteon Inc.
    Inventors: Taikyun Rho, Michael E. Lankin, David H. Shih, Claire M. Lankin
  • Bis-?hydrazones!
    Patent number: 5698563
    Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises bis(guanylhydrazone) of the formula ##STR1## capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: December 16, 1997
    Assignee: Alteon Inc.
    Inventors: Dilip R. Wagle, Michael E. Lankin, David H. Shih
  • Bis-(2-aryl) hydrazones
    Patent number: 5661139
    Abstract: The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises a bis-(2-aryl)hydrazone capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 26, 1997
    Assignee: Alteon Inc.
    Inventors: Michael E. Lankin, David H. Shih, Dilip R. Wagle, San-Bao Hwang
  • Amino-benzoic acids and derivatives, and methods of use
    Patent number: 5514676
    Abstract: The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: May 7, 1996
    Assignees: The Rockefeller University, Alteon Inc.
    Inventors: Peter C. Ulrich, Anthony Cerami, Dilip R. Wagle, Michael E. Lankin, David H. Shih, San-Bao Hwang