Patents by Inventor Michael E. Matison

Michael E. Matison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC COMPOUNDS AND COMPOSITIONS
    Publication number: 20210261524
    Abstract: The present invention provides compounds that inhibit Factor XIa or kallikrein and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of making these compounds or pharmaceutically acceptable salts thereof and compositions and methods of use thereof.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 26, 2021
    Inventors: Neil J. HAYWARD, Bertrand L. CHENARD, Yuelian XU, Roberta L. DOROW, Michael E. MATISON, Alexander KOLCHINSKI, Richard FORNICOLA
  • THERAPEUTIC COMPOUNDS AND COMPOSITIONS
    Publication number: 20210253550
    Abstract: Provided herein are compounds and compositions that inhibit Factor XIa or kallikrein and methods of using these compounds and compositions.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 19, 2021
    Inventors: Neil J. Hayward, Bertrand L. Chenard, Yuelian Xu, Roberta L. Dorow, Michael E. Matison, Alexander Kolchinski, Richard Fornicola
  • Compounds and methods for preparing methanesulfonamides
    Patent number: 7232930
    Abstract: A process for preparing (S)-(?)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: June 19, 2007
    Assignee: Pharmacia & Upjohn Company
    Inventors: Sonja Suzanne MacKey, Michael E. Matison, Haifeng Wu, Michael Paul Goble, Moses W. McMillan, Vikram Gurudath Kalthod
  • Compounds and methods for preparing methanesulfonamides
    Publication number: 20040167357
    Abstract: A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[4-[ethyl(6-fluoro-6-metylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) anll then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-lId.
    Type: Application
    Filed: November 20, 2003
    Publication date: August 26, 2004
    Inventors: Sonja Suzanne Mackey, Michael e Matison, Haifeng Wu, Paul M Herrinton, Michael Paul Goble, Moses W McMillian, Vikram Gurudath Kalthod