Abstract: The disclosure relates to a compound having Formula (I?): and in particular, Compound I-126: which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.

Abstract: The invention relates to a form for producing a pre-molded prosthesis base blank, wherein the pre-molded prosthesis base blank is provided for producing a prosthesis base for a dental prosthesis with a subtractive CAM method, wherein the form features an inner surface which is a negative of the prosthesis base blank to be produced, wherein the inner surface features a negative of a dental arch or a dental arch section with a thickening in the occlusal direction, and the form consists of at least two parts, which are affixed in such a manner that are detachable from each other or which are detachably affixable to each other. The invention also relates to a method for producing a prosthesis base blank with such a form, in which a hot polymer or cold polymer is filled into the at least dual-part compiled form, the hot polymer or cold polymer is then hardened, and as a next step, the parts of the form are detached from the hardened prosthesis base blank.

Abstract: Method for adjusting or improving or optimizing the usage properties of filler(s)-containing, flowable dental material, which involves relating to at least one measuring value representing the tackiness to at least one measuring value representing the texturing or plasticity or consistency. Flowable, usage-optimized, usually non-polymerized dental composites contain, as fillers, at least one glass filler and at least one filler from the group of chipped polymers or pre-polymer fillers based on ground polymer that is pre-polymerized together with inorganic particles, and, as additive(s), at least one compound represented through formula H—Y—Z (I), where: Y=—O—, —S—, —CO—, —OSi(OR1)2—, —OE Z=H, OH, SH, NH2, COOH, COOR2 E=—CnHmOp- R1=H, C1-C4-Alkyl R2=C1-C15-Alkyl, interrupted by one or more O atoms. C2-C14-Alkyl, n=2 bis 5 m=4 bis 11 p=n.

Abstract: Method for adjusting or improving or optimising the usage properties of filler(s)-containing, flowable dental material, which involves relating to at least one measuring value representing the tackiness to at least one measuring value representing the texturing or plasticity or consistency. Flowable, usage-optimised, usually non-polymerised dental composites contain, as fillers, at least one glass filler and at least one filler from the group of chipped polymers or pre-polymer fillers based on ground polymer that is pre-polymerised together with inorganic particles, and, as additive(s), at least one compound represented through formula H—Y—Z (I), where: Y?—O—, —S—, —CO—, —OSi(OR1)2—, —OE Z?H, OH, SH, NH2, COOH, COOR2 E=—CnHmOp- R1?H, C1-C4-Alkyl R2?C1-C15-Alkyl, interrupted by one or more O atoms.

Abstract: A toning apparatus for an electrophotographic marking engine using multi-component developer includes a magnet for producing a magnetic field through the surface of a toning member, so that carrier particles in the developer in a receiving zone are attracted to the toning member. A rotatable ribbon blender includes an axle, a first inner ribbon and a first outer ribbon having opposite handednesses of twist and arranged to rotate with the axle, and a paddle connected to the first outer ribbon. The ribbon blender is disposed at least partially in the developer in a sump, so that when the ribbon blender rotates, the paddle transports developer from the sump to the receiving zone. No feed roller or supply roller is required; the ribbon blender mixes and transports developer.

Abstract: A toning apparatus for an electrophotographic marking engine using multi-component developer includes a magnet for producing a magnetic field through the surface of a toning member, so that the carrier particles in the developer in a receiving zone are attracted to the toning member. A rotatable ribbon blender includes an axle, a first inner ribbon and a first outer ribbon having opposite handednesses of twist and arranged to rotate with the axle, and a paddle connected to the first outer ribbon. The ribbon blender is disposed at least partially in the developer in the sump, so that when the ribbon blender rotates, the paddle transports developer from the sump to the receiving zone. No feed roller or supply roller is required; the ribbon blender mixes and transports developer.

Abstract: Dental composite materials based on (meth)acrylate, exhibiting a proportion of TCD monomers in the total composition of 1-15% by weight and the quotient of flexural strength/shrinkage tension is at least 35.

Abstract: Dental composites comprising monomers, crosslinking agents, fillers, and initiators, in which the crosslinking agent comprises more than 50% by weight of the acrylate monomer TCD-DI-HEA, and the cyctotoxicity of the cured composite as determined according to the standard requirements of ISO 10993-5 and DIN EN ISO 7405 is assessed into the category “no cytotoxic potential”.

Abstract: For composite materials having a total filler content of 80 to 95% by weight, containing A) 0.5 to 10% by weight of non-agglomerated nanofillers having particle sizes of 1 to 50 nm in the filler component, B) at least 60% by weight of a filler mixture of 50 to 90% coarse-particle and 10 to 50% fine-particle dental glass in the filler component, having a size ratio, relative to the average particle size (d50 value), of coarse to fine particles of >1:4 to 1:30, C) as monomer component, a monomer mixture of i. 60 to 80% bis-GMA or TCD-di-HEMA or TCD-di-HEA, ii. 10 to 18% UDMA, iii. Residual TEDMA and/or multifunctional crosslinkers, D) up to 1% photoinitiator(s); and E) optionally, at least one additional dental glass in the filler component having a different particle size than the coarse- and fine-particle dental glass, the polymerization shrinkage may be reduced to <1.

Abstract: The invention relates generally to processes for electrographic image development. An electrographic development apparatus is provided wherein a film is adjacent a cylindrical toning shell and a mixture of toner and carrier is particles disposed on the cylindrical toning shell in contact with the film. The cylindrical toning shell is closest to the film at a first location, the mixture of toner and carrier particles being movable through the first location with a flow direction. A magnetic core disposed within the cylindrical toning shell offset toward the cylindrical shell such that a magnetic field strength is greater at the second location than the first location.

Abstract: Dental composite materials based on (meth)acrylate, exhibiting a proportion of TCD monomers in the total composition of 1-15% by weight and the quotient of flexural strength/shrinkage tension is at least 35.

Abstract: Compositions for dental composites comprising monomers, crosslinking agents, fillers, initiators, A the proportion of crosslinking agent being formed in an amount of more than 50% by acrylate monomers with a TCD urethane structure having the general formula in which A, X, Z, R1 R2 R3 and r have the meaning indicated in claim 1, provide polymerized composite materials with a particularly low cytotoxicity according to the standard requirements according to ISO 10993-5 and DIN EN ISO 7405.

Abstract: For a glide sport article, especially an ice skate with a shoe body that is located on a chassis and that includes a cap-like shoe tip forming the toe area of the shoe body, a shoe body section forming the heel area and an ankle support, lacing on the shoe body section and a tongue located beneath the lacing, the shoe tip can be adjusted in a shoe body direction relative to the shoe body section on the chassis.

Abstract: A blender for electrographic developer has an outer cylindrical surface having an axis, the blender being adapted to rotate about the axis; and a skive defining an outer edge adjacent said cylindrical surface and spanning a length along said axis.

Abstract: According to the various aspects of the invention, a method and apparatus for mixing electrographic developer is provided. An elongate shaft having two ends and an intermediate location between the two ends is rotated. Developer is moved away from the intermediate location toward one of the ends with an inner helical ribbon mounted concentrically to the elongate shaft for rotation therewith. Developer is moved away from the one of the ends toward the intermediate location with an outer helical ribbon mounted concentrically to the elongate shaft for rotation therewith, the inner helical ribbon is disposed within the outer helical ribbon. Developer is moved away from the intermediate location toward another of the ends with another inner helical ribbon mounted to the elongate shaft for rotation therewith.

Abstract: For composite materials having a total filler content of 80 to 95% by weight, containing A) 0.5 to 10% by weight of non-agglomerated nanofillers having particle sizes of 1 to 50 nm in the filler component, B) at least 60% by weight of a filler mixture of 50 to 90% coarse-particle and 10 to 50% fine-particle dental glass in the filler component, having a size ratio, relative to the average particle size (d50 value), of coarse to fine particles of >1:4 to 1:30, C) as monomer component, a monomer mixture of i. 60 to 80% bis-GMA or TCD-di-HEMA or TCD-di-HEA, ii. 10 to 18% UDMA, iii. Residual TEDMA and/or multifunctional crosslinkers, D) up to 1% photoinitiator(s); and E) optionally, at least one additional dental glass in the filler component having a different particle size than the coarse- and fine-particle dental glass, the polymerization shrinkage may be reduced to <1.

Abstract: The invention relates generally to processes for electrographic image development. An electrographic development apparatus is provided wherein a film is adjacent a cylindrical toning shell and a mixture of toner and carrier is particles disposed on the cylindrical toning shell in contact with the film. The cylindrical toning shell is closest to the film at a first location, the mixture of toner and carrier particles being movable through the first location with a flow direction. A magnetic core disposed within the cylindrical toning shell offset toward the cylindrical shell such that a magnetic field strength is greater at the second location than the first location.

Abstract: For a glide sport article, especially an ice skate with a shoe body that is located on a chassis and that comprises a cap-like shoe tip forming the toe area of the shoe body, a shoe body section forming the heel area and an ankle support, lacing on the shoe body section and a tongue located beneath the lacing, the shoe tip can be adjusted in a shoe body direction relative to the shoe body section on the chassis.

Abstract: A dental material that contains di- and poly(meth)acrylates and an inorganic filler in the form of a finely divided synthetic crystalline silicic acid with a sheet structure and optionally a very finely ground glass.