Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: The invention relates to substituted dihydropyrazolo pyrazine carboxamide derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and diabetes, and also urogenital and ophthalmic disorders.

Abstract: The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

Abstract: A method for providing a spatially perceptible acoustic signal for a rider of a two-wheeled vehicle, including: providing an acoustic signal by a two-wheeled vehicle; determining the position of a helmet worn by the rider of the two-wheeled vehicle relative to the two-wheeled vehicle; processing the acoustic signal depending on the determined position to provide a three-dimensional output signal which constitutes a binaural projection of the acoustic signal; and outputting the output signal via a stereo headset of the helmet, wherein the output signal spatially positions a sound source contained in the acoustic signal depending on the determined position, whereby the sound source is spatially locatable by the rider of the two-wheeled vehicle.

Abstract: A system for automated maneuvering of an ego vehicle includes: a recognition device configured to recognize a moving object in the surroundings of the ego vehicle and to assign the object to a specific object classification; a control device coupled to the recognition device, the control device being configured to retrieve behavior parameters for the recognized object classification from a behavior database, the behavior parameters having been determined by a method in which moving objects are classified using machine learning and are tagged on the basis of specific behavior patterns; and a maneuver planning unit coupled to the control device, the planning unit being configured to plan and execute a driving maneuver of the ego vehicle on the basis of the retrieved behavior parameter.

Abstract: The present invention pertains to an improved chemical synthesis method for Ahp-cyclodepsipeptides which allows straight forward and easy synthesis of tailor-made Ahp-cyclodepsipeptides. The invention further provides Ahp-cyclodepsipeptides for use as HTRA protease inhibitors and their medical use.

Abstract: A method for providing a spatially perceptible acoustic signal for a rider of a two-wheeled vehicle, including: providing an acoustic signal by a two-wheeled vehicle; determining the position of a helmet worn by the rider of the two-wheeled vehicle relative to the two-wheeled vehicle; processing the acoustic signal depending on the determined position to provide a three-dimensional output signal which constitutes a binaural projection of the acoustic signal; and outputting the output signal via a stereo headset of the helmet, wherein the output signal spatially positions a sound source contained in the acoustic signal depending on the determined position, whereby the sound source is spatially locatable by the rider of the two-wheeled vehicle.

Abstract: The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Abstract: An add-on shaft for an electric motor, an electric motor having an add-on shaft, an add-on shaft that drives a rotary encoder and a method for connecting an add-on shaft to a motor shaft of an electric motor are disclosed. The add-on shaft has a pin that is introduced into a centered blind hole in the motor shaft of the electric motor. The pin has sections having different diameters, so that the add-on shaft is aligned coaxially with the motor shaft and fixed in the blind hole by an interference fit, but adhesive applied onto the pin is not wiped off during the joining operation. A defined adhesive gap optimal for the adhesive used is also provided.

Abstract: The invention is directed to methods for delivery of HTRA polypeptides and its variants into mammalian cells without using transfection reagents. The HTRA polypeptides can be coupled to cargo molecules which are thereby transported into cells, e.g. for complementation, activation or inhibition of cellular pathways for basic and translational research as well as for therapy.

Abstract: A method for selecting a first area from a viewing zone which has a plurality of selectable areas is described. The method has measures a point of gaze of a user on the viewing zone, thereby providing a measured point of gaze. Furthermore, the method determines an estimated point of gaze based on the measured point of gaze and displays information regarding the estimated point of gaze on the viewing zone. The method also captures displacement information which is directed at dislocating the displayed information on the viewing zone. An actual point of gaze is determined based on the measured point of gaze and based on the captured displacement information. Furthermore, a first area which corresponds to the actual point of gaze is selected from the plurality of selectable areas.

Abstract: An add-on shaft for an electric motor, an electric motor having an add-on shaft, an add-on shaft that drives a rotary encoder and a method for connecting an add-on shaft to a motor shaft of an electric motor are disclosed. The add-on shaft has a pin that is introduced into a centered blind hole in the motor shaft of the electric motor. The pin has sections having different diameters, so that the add-on shaft is aligned coaxially with the motor shaft and fixed in the blind hole by an interference fit, but adhesive applied onto the pin is not wiped off during the joining operation. A defined adhesive gap optimal for the adhesive used is also provided.

Abstract: The invention relates to a method of screening a subject for at least one risk factor associated with a neurodegenerative disease such as Alzheimer's disease comprising detecting the presence or absence of at least one risk marker in the HtrA1 gene (PRSS11). Furthermore, diagnostic kits as well as therapeutic approaches are provided.

Abstract: A series of fabricated products for electrically rotatably driven machines, especially alternating current motors for attachment on drives, for alternating current motors having various pole configurations and operable in differing performance classes, voltage classes, and frequency classes, includes a plurality of trunk motors each having a motor housing, a motor terminal box for the provision of electrical current to stator windings mounted in a rotationally symmetrical manner in the motor housing, and a rotor. The rotor has a shaft supported on a bearing bracket. The trunk motor also includes a drive side, a non-drive side, and a shaft end extending outwardly from the non-drive side adapted for the securement thereto of a plurality of differing attachment shafts.

Abstract: A series of fabricated products for electrically rotatably driven machines, especially alternating current motors for attachment on drives, for alternating current motors having various pole configurations and operable in differing performance classes, voltage classes, and frequency classes, includes a plurality of trunk motors each having a motor housing, a motor terminal box for the provision of electrical current to stator windings mounted in a rotationally symmetrical manner in the motor housing, and a rotor. The rotor has a shaft supported on a bearing bracket. The trunk motor also includes a drive side, a non-drive side, and a shaft end extending outwardly from the non-drive side adapted for the securement thereto of a plurality of differing attachment shafts.