Abstract: A prosthetic heart valve can include an outer support assembly, an inner valve assembly, which define between them an annular space, and a pocket closure that bounds the annular space to form a pocket in which thrombus can be formed and retained. Alternatively, or additionally, the outer support assembly and the inner valve assembly can be coupled at the ventricle ends of the outer support assembly and the inner valve assembly, with the outer support assembly being relatively more compliant in hoop compression in a central, annulus portion than at the ventricle end, so that the prosthetic valve can seat securely in the annulus while imposing minimal loads on the inner valve assembly that could degrade the performance of the valve leaflets.

Abstract: A prosthetic heart valve can include an outer frame coupled to an inner frame such that the outer frame can be moved between a first position and a second position in which the outer frame is inverted relative to the inner frame. The inner frame and the outer frame define between them an annular space, and a pocket closure can bound the annular space to form a pocket in which thrombus can form and be retained. The pocket closure can include a stretchable pocket covering that can move from a first position in which the pocket covering has a first length when the outer frame is in the first position relative to the inner frame and a second position in which the pocket covering has a second length greater than the first length when the outer frame is in the second position relative to the inner frame.

Abstract: The present invention relates to systems and methods for intelligently optimizing supply chain is provided. In particular, the systems and methods provide the capability to configure supply chain systems so as to: balance between cost and service is optimised and profitability maximised; configure system parameters to respond to both current and future risks; ensure that variability is built into plans enabling maximised efficiency; and human error and bias are eliminated from the planning process such that pro-active rather than reactive behaviour becomes the norm.

Abstract: The present invention provides compounds of formula (I): Formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, Y, n, R1, R2A, R2B, R3 and *1 are as defined herein.

Abstract: The present invention provides compounds of formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, and, n, are as defined herein.

Abstract: Cell sorting methods that improve sorting efficiency and productivity by elevating sorting pressures and incorporate certain steps to help the cells better survive such elevated pressures. In the case of sperm, sorting the steps of standardizing sperm samples, staining sperm samples in a single step, calibrating a flow cytometer to place sperm in the leading edge of droplets, and changing a catch fluid distance may be incorporated individually, or in combination to help sperm better survive the sex sorting process.

Abstract: The present invention provides methods of monitoring and measuring tumor-associated free PSA (“fPSA”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments. The present invention also provides various methods and compositions relating to antibodies that are specific for tumor-associated or intratumoral fPSA. For example, the present invention provides compositions, including pharmaceutical compositions, comprising anti-fPSA antibodies, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using anti-fPSA antibodies and/or compositions.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: The present invention provides compounds of formula (I) or (Ia) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.

Abstract: Disclosed herein are compounds useful for detection of glucocorticoid receptor expression and activity via positron emission tomography and related techniques. Methods for preparation and use of the compounds are also described.

Abstract: Techniques and devices are disclosed for fabrication layout device. The device includes a table with a work surface. The work surface being a continuous surface and configured to support a plurality of railing pieces for fabrication of a railing assembly. The device further includes a beam located above the work surface. The beam is operatively coupled to the table, such that the beam moves relative to the work surface in a first direction. Attached to the beam is an ink dispenser. The ink dispenser is configured to move along the beam in a second direction different from the first direction. The ink dispenser is further configured to dispense ink onto the work surface of the table in the form of a pattern of the railing assembly. Railing pieces are positioned on the pattern so that they can be assembled to one another.

Abstract: Example methods, apparatus, systems and articles of manufacture (e.g., physical storage media) to deduplicate common devices across multiple data sources are disclosed. An example system includes a comparison controller to identify a first device in a first data source and a second device in a second data source as a possible common device.

Abstract: The invention encompasses a rapid and safe preparation method of sperm nuclei, improved sperm nuclei and a method of using the improved sperm nuclei to calibrate a flow cytometer with higher accuracy.

Abstract: In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.

Abstract: Systems and methods are provided for efficiently performing processing intensive operations, such as those involving large volumes of data, that enable accelerated processing time of these operations. In at least one embodiment, a system includes a graphics processor unit (GPU) including a memory and a plurality of cores. The plurality of cores perform a plurality of data analytics operations on a respectively allocated portion of a dataset, each of the plurality of cores using only the memory to store data input for each of the plurality of data analytics operations performed by the plurality of cores. The data storage for the plurality of data analytics operations performed by the plurality of cores is also provided solely by the memory.

Abstract: The present disclosure is directed to systems and methods for managing on-site communications of a machine with a latency-dependent application installed. The method includes, for example, (i) receiving geographical information associated with a work site; (ii) receiving historical communications information associated with the work site; (iii) analyzing the historical communications information and the geographical information; (iv) generating an instruction for implementing the latency-dependent application of the machine based on a latency requirement of the latency-dependent application; and (v) implementing the latency-dependent application of the machine based on the instruction. The historical communications information includes a communications event, a duration of the communications event, and a frequency of the communications event.

Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to determine total audience ratings. An example apparatus includes metrics generator circuitry to generate a first audience size for media accessed by first devices of a first media platform at a first level of aggregation, the first level of aggregation corresponding to the media accessed on a first television network and on a first website, generate a second audience size for the media accessed by the first devices of the first media platform at a second level of aggregation, the second level of aggregation corresponding to the media accessed on the first television network and accessed on the first website and a second website, comparator circuitry to compare the first audience size to the second audience size, adjustor circuitry to reduce the first audience size based on the second audience size, and audience determination circuitry to determine a total audience size.

Abstract: The present invention provides compounds of formula (I), compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, R12, R13, A, L, B, n, W, X, Y and Z are as defined herein.

Abstract: Methods, apparatus, systems and articles of manufacture to determine whether a smart device is in-tab are disclosed. An example apparatus includes memory; instructions in the apparatus; and processor circuitry to execute the instructions to: provide smart television data from a smart television as an input to a model to generate an output, the smart television data being included in population data from a population of smart televisions; determine a tab status of the smart television based on the output; in response to the tab status of the smart television being out-of-tab, remove the smart television data from the population data; and credit media based on the population data.