Patents by Inventor Michael F. McManus

Michael F. McManus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230335290
    Abstract: A method determines an internal state variable. The method receives patient data and a model of an internal state variable. The internal state variable is calculated using the patient data and the model of the internal state variable. Gold standard data corresponding to the internal state variable is received. A statistical performance assessment of the model of the internal state variable is performed. The method determines whether a performance of the model of the internal state variable is above a prescribed threshold. A source of inconsistent data negatively impacting the performance of the model of the internal state variable is determined.
    Type: Application
    Filed: April 13, 2023
    Publication date: October 19, 2023
    Inventors: Michael F. McManus, Dimitar V. Baronov, Robert Hammond-Oakley
  • Publication number: 20230317296
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: June 7, 2023
    Publication date: October 5, 2023
    Applicant: Etiometry Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Patent number: 11676730
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: June 13, 2023
    Assignee: Etiometry Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Patent number: 11482336
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: October 25, 2022
    Assignee: Etiometry Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20220310266
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: May 17, 2022
    Publication date: September 29, 2022
    Applicants: Etiometry, Inc., Etiometry, Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20220293279
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: May 17, 2022
    Publication date: September 15, 2022
    Applicants: Etiometry, Inc., Etiometry, Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20220115143
    Abstract: Systems and methods produce a quantitative indication of the influence, on determination of a patient's clinical risk, of one or more measurements of one or more internal state variables. Illustrative embodiments compute a reference patient's clinical risk of being in a specific patient state using measurements of measurable internal state variables, and compute alternates of the same clinical risk using alternate values for at least one of the measurements of measurable internal state variables, and determine which of the measurements of internal state variables have the greatest quantitative impact on the patient's clinical risk by comparing the reference clinical risk to the alternate clinical risks.
    Type: Application
    Filed: October 14, 2021
    Publication date: April 14, 2022
    Inventors: Dimitar V. Baronov, Michael F. McManus
  • Publication number: 20210104328
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 8, 2021
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20210090742
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: September 25, 2020
    Publication date: March 25, 2021
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Patent number: 10796804
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: October 6, 2020
    Assignee: Etiometry, Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20180366229
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Patent number: 10062456
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: August 28, 2018
    Assignee: Etiometry Inc.
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20150347704
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: June 1, 2015
    Publication date: December 3, 2015
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Patent number: 9007260
    Abstract: A method and apparatus for estimating and compensating for a broad class of non-Gaussian sensor and process noise. In one example, a coded filter combines a dynamic state estimator (for example, a Kalman filter) and a non-linear estimator to provide approximations of the non-Gaussian process and sensor noise associated with a dynamic system. These approximations are used by the dynamic state estimator to correct sensor measurements or to alter the dynamic model governing evolution of the system state. Examples of coded filters leverage compressive sensing techniques in combination with error models based on concepts of compressibility and the application of efficient convex optimization processes.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: April 14, 2015
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Yaron Rachlin, Rami Mangoubi, Michael F. McManus, Christopher C. Yu
  • Patent number: 8978474
    Abstract: A micro-electro-mechanical systems (MEMS) inertial measurement system facilitates accurate location and/or attitude measurements via passive thermal management of MEMS inertial sensors. Accuracy of the system is also improved by subjecting the inertial sensors to programmed single-axis gimbal motion, and by performing coarse and fine adjustments to the attitude estimates obtained by the system based on the programmed motion and on the passive thermal management of the sensors.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: March 17, 2015
    Assignees: The Charles Stark Draper Laboratory, Inc., Massachusetts Institute of Technology
    Inventors: Matthew S. Bottkol, Richard D. Elliott, Michael Y. Feng, Thomas F. Marinis, Michael F. Mcmanus, Shan Mohiuddin, Peter G. Sherman, John E. Pritchett, Jeffery W. Warren, Charles H. Lange
  • Publication number: 20130231949
    Abstract: A risk-based patient monitoring system for critical care patients combines data from multiple sources to assess the current and the future risks to the patient, thereby enabling providers to review a current patient risk profile and to continuously track a clinical trajectory. A physiology observer module in the system utilizes multiple measurements to estimate Probability Density Functions (PDF) of a number of Internal State Variables (ISVs) that describe a components of the physiology relevant to the patient treatment and condition. A clinical trajectory interpreter module in the system utilizes the estimated PDFs of ISVs to identify under which probable patient states the patient can be currently categorized and assign a probability value that the patient will be in each of the identified states. The combination of patient states and their probabilities is defined as the clinical risk to the patient.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 5, 2013
    Inventors: Dimitar V. Baronov, Evan J. Butler, Jesse M. Lock, Michael F. McManus
  • Publication number: 20130025369
    Abstract: A micro-electro-mechanical systems (MEMS) inertial measurement system facilitates accurate location and/or attitude measurements via passive thermal management of MEMS inertial sensors. Accuracy of the system is also improved by subjecting the inertial sensors to programmed single-axis gimbal motion, and by performing coarse and fine adjustments to the attitude estimates obtained by the system based on the programmed motion and on the passive thermal management of the sensors.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 31, 2013
    Inventors: Matthew S. Bottkol, Richard D. Elliott, Michael Y. Feng, Thomas F. Marinis, Michael F. McManus, Shan Mohiuddin, Peter G. Sherman, John E. Pritchett, Jeffery W. Warren, Charles H. Lange
  • Publication number: 20120127029
    Abstract: A method and apparatus for estimating and compensating for a broad class of non-Gaussian sensor and process noise. In one example, a coded filter combines a dynamic state estimator (for example, a Kalman filter) and a non-linear estimator to provide approximations of the non-Gaussian process and sensor noise associated with a dynamic system. These approximations are used by the dynamic state estimator to correct sensor measurements or to alter the dynamic model governing evolution of the system state. Examples of coded filters leverage compressive sensing techniques in combination with error models based on concepts of compressibility and the application of efficient convex optimization processes.
    Type: Application
    Filed: June 23, 2011
    Publication date: May 24, 2012
    Applicant: THE CHARLES STARK DRAPER LABORATORY, INC.
    Inventors: Yaron Rachlin, Rami Mangoubi, Michael F. McManus, Christopher C. Yu
  • Patent number: 5141352
    Abstract: A seat belt anchor with a first leg which has a first shank carried by a first base. The shank is elongate, generally tubular, with a top, a longitudinal axis, and an axial recess. The axial recess has an end which is open to the top of the shank. The base, which carries the shank, is generally flat with top and bottom surfaces and a hole for receiving a bolt.The first base is joined to the first shank at the end of the shank distal from the top of the shank and the open end of the recess. The longitudinal axis of the first shank is curved toward the top of the first base at a first curving angle A which is less than 180 degrees, desirably, 110 to 140 degrees and preferably about 135 degrees.The first curving angle A has an apex which is disposed a first selected distance from the top of the first shank.The seat belt anchor has a second leg similar to the first leg.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: August 25, 1992
    Assignee: Header Products, Inc.
    Inventors: Michael F. McManus, Robert Lawery, Michael C. Shutt