Abstract: In an approach for autonomous claim requirements discovery of APIs, a processor receives an access request from a client to a server. A processor validates the access request. A processor queries claim requirements in a claim document from the server upon the validation of the access request. A processor receives the claim requirements. A processor constructs a token based on the claim requirements. A processor sends the token to the server. A processor receives a response from the server. A processor sends the response to the client.

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

Abstract: A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, athiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.

Abstract: Aspects of the present disclosure relate to techniques for managing transactions, including receiving a first transaction request directed to an account of a first web application. Additionally, initiating, by a rate-limiting engine, a rate-limiting process in response to the first transaction request. The techniques further include obtaining a rate-limiting identifier, where the rate limiting identifier uniquely identifies the first web application, and where the rate-limiting identifier identifies an account owner. The techniques further include determining an alternate notification method exists for the account owner and sending a verification request to the account owner, where the verification request is sent using the alternate notification method. The techniques further include receiving a response to the verification request, performing a risk assessment, and adjusting a first security parameter in response to the risk assessment.

Abstract: Disclosed herein are methods and compositions for detecting differential expression of certain miRNAs in cancer cells or their surrounding normal tissues in the tumor microenvironment. The disclosure describes an automated, highly sensitive and specific method for detection of any cellular RNA molecule, including microRNA, messenger RNA and non-coding RNA. The technology includes probe design as well as probe use in an automated fashion for detection of RNA molecules in formalin-fixed paraffin-embedded tissue (FFPET) samples.

Abstract: The techniques described herein relate to methods and apparatus for firearm safety mechanisms, visual safety indicators, and related techniques. A firearm includes a handle with one or more sensors disposed at least partially within a surface of the handle. The firearm also includes a trigger that is actuatable to fire the firearm, and a safety mechanism that has a first position that blocks actuation of the trigger and a second position that does not block the trigger. The firearm further includes at least one processor configured to receive data from the one or more sensors, process the received data to determine whether the data is indicative of sufficient contact of the operator's hand with the one or more sensors, and upon determining the data is indicative of sufficient contact, transmitting a signal to the safety mechanism to change the safety mechanism from the first position to the second position.

Abstract: A bicycle frame is discussed having a battery fully contained within a down tube of the bicycle frame. The battery may be inserted into or removed from the down tube via a through opening through a bottom bracket housing of the bicycle frame. Weakness in the bottom bracket housing due to the through opening may be compensated for, fully or partially, by utilizing a bottom bracket bearing assembly that has a structural component, or structural component assembly, that extends completely through the bottom bracket housing and removably couples to the bottom bracket housing.

Abstract: Disclosed herein are methods and compositions for detecting differential expression of certain miRNAs in cancer cells or their surrounding normal tissues in the tumor microenvironment. The disclosure describes an automated, highly sensitive and specific method for detection of any cellular RNA molecule, including microRNA, messenger RNA and non-coding RNA. The technology includes probe design as well as probe use in an automated fashion for detection of RNA molecules in formalin-fixed paraffin-embedded tissue (FFPET) samples.

Abstract: A bicycle water bottle system is provided. The system includes a mount having a mounting base and a mounting plate extending substantially perpendicular to the mounting base. The mounting base may be configured to connect to a bicycle frame using two fixed pre-formed mounting screw holes. The system also includes a water bottle having a slot formed in one side of the water bottle. The mounting plate is shaped and sized to fit tightly into the slot of the water bottle and the slot is correspondingly shaped and sized to receive the mounting plate to secure the water bottle to the mounting plate.

Abstract: A method for selecting a communication protocol for a virtual desktop instance in a service provider environment may include providing to a client computing device, access to a virtual desktop instance running on a server computer using a first communication channel associated with a first communication protocol. A request for functionality from a user of the device is detected, the requested functionality being unsupported by the first communication protocol. A second communication protocol from a plurality of available communication protocols may be selecting based on the requested functionality. The second communication protocol may support the requested functionality. A user authorization for using the second communication protocol can be verified.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Abstract: Aspects of the present disclosure relate to techniques for managing transactions, including receiving a first transaction request directed to an account of a first web application. Additionally, initiating, by a rate-limiting engine, a rate-limiting process in response to the first transaction request. The techniques further include obtaining a rate-limiting identifier, where the rate limiting identifier uniquely identifies the first web application, and where the rate-limiting identifier identifies an account owner. The techniques further include determining an alternate notification method exists for the account owner and sending a verification request to the account owner, where the verification request is sent using the alternate notification method. The techniques further include receiving a response to the verification request, performing a risk assessment, and adjusting a first security parameter in response to the risk assessment.

Abstract: A computer-implemented system and method include a rate-limiting server. The server receives a request from a client and uses an early stage process to search for a rate-limiting token bucket (TB) using metadata associated with the request. Responsive to finding the TB using the first metadata, a response operation is performed. Responsive to not finding the TB using the first metadata, a late stage process is used to search for the rate-limiting TB using server-side session data associated with the request. Responsive to not finding the TB using the session data, the TB is created and associated with at least two search indexes comprising the first metadata associated with the request and the session data. Finally, the response operation is performed that comprises transmitting a determined response to the client.

Abstract: Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.

Abstract: Systems and methods for increasing security in security systems and alarm systems that use mesh networks are provided. In some embodiments, such systems and methods can include a mesh controller activating diagnostic, configuration, and control functions of a service device in response to physical activation of the a verification device, the service device using the diagnostic, configuration, and control functions of the service device to add a new mesh element to a plurality of mesh elements, and one of the plurality of mesh elements detecting a signal transmitted during an assigned time slot of the one of the plurality of mesh elements from a device other than the one of the plurality of mesh elements and, responsive thereto, disrupting transmission of the signal.

Abstract: A remote computing session management process is directed to the execution and management of aspects of virtual instances executed on data center computers at a program execution service (PES) platform. A computing session may be established between the PES platform and a computing device connected to the PES platform over a communications network. The data created by the user of the client computing device interacting with the virtual instance may be stored, and following an interruption of the remote computing session, the data may be used when re-establishing the remote computing session.

Abstract: A method and apparatus for dynamic rotation of streaming protocols are disclosed. In the method and apparatus, a first portion of content is streamed to a client device in accordance with a first content delivery protocol. Further, information indicating client device attributes, network conditions or usage conditions is received. A plurality of content delivery protocols including the first content delivery protocol are evaluated based at least in part on the received information to identify a content delivery protocol for streaming the a second portion of the content.

Abstract: A remote computing session management process is directed to the execution and management of aspects of virtual instances executed on data center computers at a program execution service (PES) platform. A computing session may be established between the PES platform and a computing device connected to the PES platform over a communications network. The data created by the user of the client computing device interacting with the virtual instance may be stored, and following an interruption of the remote computing session, the data may be used when re-establishing the remote computing session.

Abstract: An apparatus for assessing patient breathing and cardiovascular condition of a patient includes a storage medium for storing data regarding the breathing and cardiovascular condition of the patient, a processor in communication with the storage medium, the processor being configured to prompt the patient with a series of queries relating to patient breathing and cardiovascular condition, a display for presenting the patient with the series of queries and a date entry device for receiving responses to the series of queries. The processor is configured to tally positive responses to the series of queries to generate a sleep disordered breathing index.

Abstract: Systems and methods are presented for enabling a user to provide rules for the placement of computing resources at a data center for an entity that employs or is associated with the user. The data center can use the placement rules to select a data center computer system to host computing resources for a user. The rules can be used to establish diversity in computing resource placement at the data center thereby reducing the number of users who lose access to computing resources when a specific data center computer suffers a failure. Further, the placement rules can be used to facilitate configuration of the computer resources for the user based, for example, on the user's employment responsibilities.