Patents by Inventor Michael Fedouloff

Michael Fedouloff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of an indole derivative
    Patent number: 6946565
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Grant
    Filed: January 30, 2003
    Date of Patent: September 20, 2005
    Assignee: SmithKline Beecham PLC
    Inventors: Michael Fedouloff, John Bryce Strachan
  • Process for the preparation of an indole derivative
    Publication number: 20040192911
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Application
    Filed: April 5, 2004
    Publication date: September 30, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Michael Fedouloff, John Bryce Strachan
  • Novel processes for the preparation of 4-phenylpiperidine derivatives
    Publication number: 20040087795
    Abstract: A process for preparing compound (E) from compound (A), with or without isolation of intermediate products, characterised by one or more of the following steps:
    Type: Application
    Filed: June 24, 2003
    Publication date: May 6, 2004
    Inventors: Gary Thomas Borrett, Michael Fedouloff, Mark Jason Hughes, Andrew Colin Share, John Bryce Strachan, Peter Szeto, Martyn Voyle
  • Process for the preparation of an indole derivative
    Patent number: 6583294
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: June 24, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Michael Fedouloff, John Bryce Strachan
  • Process for the preparation of an indole derivative
    Publication number: 20030114684
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Application
    Filed: January 30, 2003
    Publication date: June 19, 2003
    Applicant: SmithKline Beecham plc
    Inventors: Michael Fedouloff, John Bryce Strachan
  • PROCESS FOR THE PREPARATION OF AN INDOLE DERIVATIVE
    Publication number: 20030083506
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Application
    Filed: December 3, 2002
    Publication date: May 1, 2003
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Michael Fedouloff, John Bryce Strachan
  • Process for the preparation of an indole derivative
    Publication number: 20020091271
    Abstract: A process for the preparation of methyl 2-(3-chloropropoxy)-indole-3-carboxylate, which comprises reacting a 3-chloro-3-carboxylate indole compound with 3-chloropropanol in the presence of an acid having a pKa of from 0 to 2.
    Type: Application
    Filed: March 8, 2002
    Publication date: July 11, 2002
    Applicant: SmithKline Beecham plc
    Inventors: Michael Fedouloff, John Bryce Strachan
  • Preparation of 1-butyl-4-piperidinylmethylamine
    Patent number: 6331631
    Abstract: A process for the preparation of 1-butyl-4-piperidinylmethylamine using toluene as a solvent is disclosed.
    Type: Grant
    Filed: August 22, 2000
    Date of Patent: December 18, 2001
    Assignee: SmithKline Corporation p.l.c.
    Inventors: Michael Fedouloff, David William Guest, Gillian Elizabeth Smith
  • Pharmaceuticals
    Publication number: 20010031751
    Abstract: Novel oxazino[3,2-a]indole-10-carboxamide derivatives having 5-HT4 receptor antagonist activity and useful in the treatment of gastrointenstinal disorders, cardiovascular disorders and CNS disorders, inclusing irritable bowel syndrome.
    Type: Application
    Filed: April 30, 2001
    Publication date: October 18, 2001
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Brian David Bush, Michael Fedouloff, Frank Hossner
  • Process for the preparation of N-[(1-.sup.n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
    Patent number: 6100397
    Abstract: A process for the preparation of SB 207266 or a pharmaceutically acceptable salt thereof, which process comprises the reaction of N-(1-.sup.n butyl-4-piperidyl)methylamine with a compound of formula (A), ##STR1## wherein R is alkyl.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 8, 2000
    Assignee: Smithkline Beecham plc
    Inventors: Michael Fedouloff, Gillian Elizabeth Smith, David William Guest, John Bryce Strachan
  • Process for preparing epoxides
    Patent number: 6031115
    Abstract: A process for preparing compounds of formula (B) wherein:one of A.sub.1 ' or A.sub.2 ' represents hydrogen and the other represents a group CF.sub.3 --Y-- wherein Y represents --CF.sub.2 --, >C.dbd.O, or --CH(OH)--, or A.sub.1 ' and A.sub.2 ' are groups convertible to A.sub.1 and A.sub.2 respectively.Y.sub.1 represents --O--, --CH.sub.2 -- or NR.sup.O wherein R.sup.O is hydrogen, alkyl or alkylcarbonyl; R.sub.1 and R.sub.2 independently represent hydrogen or alkyl; orR.sub.1 and R.sub.2 together represent a C.sub.2-7 polymethylene moiety;R.sub.3 represents hydrogen, hydroxy, alkoxy or acyloxy and R.sub.4 is hydrogen or R.sub.3 and R.sub.4 together represent a bond;which process comprises reacting a compound of formula (C): ##STR1## wherein the variable A.sub.1 ', A.sub.2 ', Y.sub.1, R.sub.1 and R.sub.2 are as defined above, in the presence of an oxygen source and a chiral catalyst as defined in WO/91/14694.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: February 29, 2000
    Assignee: SmithKline Beecham plc
    Inventors: David Bell, Michael Fedouloff, Gillian Turner