Abstract: Imaging systems and methods of multiple fluorophore visualization involving a videoscope. According to embodiments of the disclosure simultaneous visualization of each fluorophore the spatial distribution of fluorophores could be separately visualized by fusing the images and colouring each fluorophore differently. The distribution of each fluorophore could allow for Boolean logic on the fluorescence singles where the combination of fluorophores detected in each pixel is indicative of the state of the tissue.

Abstract: A visualization system and methods for simultaneously visualizing white light and visible fluorescent light, the visualization involving an illumination system and an imaging system operable with the illumination system. The illumination system has a light source produces illumination light (white light and fluorescence excitation light), an optical notch rejection filter to remove light having peak fluorescence excitation wavelengths from the illumination light, and illumination optics to at least one of deliver and condense the filtered illumination light.

Abstract: A surgical imaging system is described. The system includes first and second optical assemblies. Each optical assembly defines a respective optical axis, and each includes a respective set of one or more optics for adjusting field-of-view (FOV) and focus and a respective camera for capturing an image. The system includes a controller for controlling the optical assemblies and for switching the surgical imaging system between a coupled configuration and an uncoupled configuration. In the coupled configuration, the first optical assemblies are controlled to adjust the respective sets of optics and/or the respective optical axes in dependence on each other. In the uncoupled configuration, the optical assemblies are controlled to adjust the respective sets of optics, and the respective optical axes independently of each other.

Abstract: A multispectral synchronized imaging system is provided. A multispectral light source of the system comprises: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further comprises a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.

Abstract: An apparatus and method is provided for intraoperative tissue stimulation during port-based surgery. The apparatus includes an access port and electrical terminals attached to the access port for tissue stimulation. In an alternative embodiment, the apparatus may include an access port, with or without electrical terminals attached to the access port for tissue stimulation, and electrocorticography sensors attached to the access port. The method includes inserting an access port into a tissue, applying an electrical potential to the tissue using electrical terminals attached to the access port, and measuring consequent neural activity using electrocorticography sensors attached to the access port.

Abstract: A cognitive optical system for dynamically refining imaging during a medical procedure, involving a processor operable by a set of executable instructions storable in relation to a non-transitory memory device. The processor is configured to automatically adjust an image by automatically compensating for at least one external factor affecting an anatomical area being viewed, automatically adjusting at least one imaging parameter, and automatically adjusting at least one internal control of an optical chain, whereby a quality of the image is improvable in real time.

Abstract: Methods and systems for outputting depth data during a medical procedure on a patient. Depth data is outputted, representing at least one of relative depth data and general depth data. Tracking information about the position and orientation of a medical instrument and depth information about variations in depth over a site of interest are used. Relative depth data represents the depth information relative to the position and orientation of the instrument. General depth data represents the depth information over the site of interest independently of the position and orientation of the instrument.

Abstract: A conductor-less, shape-able, surgical lighting system and methods for use in surgical applications in which a medical clinician, once having established a surgical site, can shape the lighting system to selectively illuminate desired volumes of the surgical site. The system includes preselected lengths of an elongate light emitting member formed of a transparent elastomer matrix material having a glass transition temperature of lower than or substantially equal to room temperature to render the elongate light emitting member bendable and shape-able. Embedded in the transparent elastomer matrix material are particles of a transparent material having a refractive index different from a refractive index of the matrix material dispersed in the elastomer matrix material so that light coupled into the elongate light emitting member is scattered and refracted out of the elongate light emitting member along its length. One end of the elongate light emitting member is coupled with a light source.

Abstract: An optical imaging system for imaging a target during a medical procedure, the imaging system involving an optical assembly having moveable zoom optics and moveable focus optics, a zoom actuator and a focus actuator for positioning the zoom and focus optics, respectively, a controller for controlling the zoom and focus actuators independently in response to received control input, a camera for capturing an image of the target from the optical assembly, the system capable of performing autofocus during a medical procedure.

Abstract: A phantom is disclosed containing fluorescence properties similar to anatomy that is needed to be visualized during surgical procedures. The phantom is created using substances including fluorophores that respond to UV light excitation to give visual cues of the phantom. The phantom can vary in phase and fluorescent properties depending on what it needs to simulate in the medical field with the purpose to help train users for surgical and diagnostic procedures, and develop, enhance, and calibrate imaging technology.

Abstract: The present disclosure provides systems and methods for diagnosing disease. In some aspects, an imaging system is provided that includes a light source configured to illuminate a retina of the eye with light, one or more imaging devices configured to receive light returned from the retina to generate one or more spatial-spectral images of the retina, and a computing device configured to receive the one or more spatial-spectral images of the retina, evaluate the one or more spatial-spectral images, and identify one or more biomarkers indicative of a neurogenerative pathology.

Abstract: Methods and systems for controlling a surgical microscope. Moveable optics of the surgical microscope are controlled using two sets of control parameters, to reduce jitter and image instability. Shifts in the image due to changes in temperature or due to the use of optical filter can also be compensated. Misalignment between the mechanical axis and the optical axis of the surgical microscope can also be corrected.

Abstract: An optical imaging system for imaging a target during a medical procedure, the imaging system involving an optical assembly having moveable zoom optics and moveable focus optics, a zoom actuator and a focus actuator for positioning the zoom and focus optics, respectively, a controller for controlling the zoom and focus actuators independently in response to received control input, a camera for capturing an image of the target from the optical assembly, the system capable of performing autofocus during a medical procedure.

Abstract: A flexible high-resolution endoscope apparatus and methods involving a plurality of optical fiber bundles; a plurality of lenses in a one-to-one correspondence with the plurality of optical fiber bundles, each lens of the plurality of lenses comprising a distinct depth of field and a distinct angle of view in relation to another lens of the plurality of lenses; and a plurality of cameras in a one-to-one correspondence with the plurality of optical fiber bundles.

Abstract: An optical imaging system for imaging a target during a medical procedure, the imaging system involving an optical assembly having moveable zoom optics and moveable focus optics, a zoom actuator and a focus actuator for positioning the zoom and focus optics, respectively, a controller for controlling the zoom and focus actuators independently in response to received control input, a camera for capturing an image of the target from the optical assembly, the system capable of performing autofocus during a medical procedure.

Abstract: A surgical camera system, and method therefor, is provided which includes a plurality of imaging devices each having a tunable iris configured to change between at least two different sized numerical apertures.

Abstract: A flexible high resolution endoscope is provided herein. The endoscope comprises: a plurality of optical fiber bundles; a plurality of lenses in a one-to-one relationship with the plurality of optical fiber bundles; and, a plurality of cameras in a one-to-one relationship with the plurality of optical fiber bundles, each respective optical fiber bundle, of the plurality of optical fiber bundles, having a respective lens, of the plurality of lenses, located at a respective distal end, and a camera, of the plurality of cameras, located at a respective proximal end, the plurality of optical fiber bundles being coupled together at a common distal end, and otherwise being uncoupled from one another, a bending radius of the endoscope defined by a largest respective bending radius of each of the plurality of optical fiber bundles.

Abstract: A 3D navigation system and methods for enhancing feedback during a medical procedure, involving: an optical imaging system having an optical assembly comprising movable zoom optics and movable focus optics, a zoom actuator for positioning the zoom optics, a focus actuator for positioning the focus optics, a controller for controlling the zoom actuator and the focus actuator in response to received control input, at least one detector for capturing an image of at least one of a target and an obstacle, the at least one detector operable with the optical assembly, and a proprioception feature operable with the optical imaging system for generating a 3D perception, the proprioception feature comprising a communication feature for providing 3D information, the 3D information comprising real-time depth information in relation to real-time planar information within an interrogation volume.

Abstract: A sensored surgical tool, surgical intraoperative tracking and imaging system incorporating same, and methods, involving a rigid elongate tool body having a substantially rigid tool tip to be displaced and tracked within the surgical cavity so to reproducibly locate the tool tip within the cavity. The tool has one or more tool tip cameras and/or pressure sensors operatively disposed along the body at or proximal to the tool tip.

Abstract: Imaging systems and methods involving a videoscope including cameras; a filter feature in optical communication with the cameras, the filter feature configured to independently filter or tandemly filter light from each camera; an independently adjustable aperture in optical communication with the filter feature, the independently adjustable aperture configured to limit transmission of filtered light; independently adjustable zoom features in optical communication with the independently adjustable aperture, the independently adjustable zoom features including corresponding independently adjustable zoom channels, and each independently adjustable zoom feature configured to independently zoom independently limited filtered light; a prism in optical communication with the independently adjustable zoom channels, the prism configured to redirect independently zoomed, independently limited, filtered light; and a shared focus feature in optical communication with the prism, the shared focus feature comprising a share