Abstract: Provided herein are antisense oligonucleotides (AONs) that induce skipping of exon 51 of human dystrophin pre-mRNA, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the AONs and methods of using the AONs and compositions for treating a subject with Duchenne muscular dystrophy.

Abstract: A device, system, and method are provided for inspecting, activating or voiding scratch-off instant lottery tickets. A remote point-of-sale device has a detector system that detects tampering with the coating placed over concealed game play information on the tickets, and reads coded identification and authentication information on the tickets. The device automatically communicates the coded identification and tampering data to a central computer system of a lottery. The central computer system provides activation signals back to the point of sale on a ticket-by-ticket basis. The device, method and system provide automated generation and communication of ticket-by-ticket tampering, activation, and voiding data between the remote device and a central computer system of a lottery.

Abstract: A method, system and device for inspection of a lottery ticket uses a device to scan lottery tickets to detect information concerning the amount of scratch-off material, such as a coating or a covering, that has been removed from a ticket, and/or the type, amount, or content of underlying indicia that have been revealed by the scratches. The system may use the information to calculate and set or determine a tolerance level for scratching below which a ticket will not be invalidated, based on parameters that may include the amount of surface area that has been scratched, and/or the type, amount, or content of underlying indicia that has been revealed. The system enables a user to input information to reset the threshold volume to a user-selected volume above which invalidation is triggered.

Abstract: A device, system, and method are provided for inspecting, activating or voiding scratch-off instant lottery tickets. A remote point-of-sale device has a detector system that detects tampering with the coating placed over concealed game play information on the tickets, and reads coded identification and authentication information on the tickets. The device automatically communicates the coded identification and tampering data to a central computer system of a lottery. The central computer system provides activation signals back to the point of sale on a ticket-by-ticket basis. The device, method and system provide automated generation and communication of ticket-by-ticket tampering, activation, and voiding data between the remote device and a central computer system of a lottery.

Abstract: A device, system, and method are provided for inspecting, activating or voiding scratch-off instant lottery tickets. A remote point-of-sale device has a detector system that detects tampering with the coating placed over concealed game play information on the tickets, and reads coded identification and authentication information on the tickets. The device automatically communicates the coded identification and tampering data to a central computer system of a lottery. The central computer system provides activation signals back to the point of sale on a ticket-by-ticket basis. The device, method and system provide automated generation and communication of ticket-by-ticket tampering, activation, and voiding data between the remote device and a central computer system of a lottery.

Abstract: A device, system, and method are provided for inspecting, activating or voiding scratch-off instant lottery tickets. A remote point-of-sale device has a detector system that detects tampering with the coating placed over concealed game play information on the tickets, and reads coded identification and authentication information on the tickets. The device automatically communicates the coded identification and tampering data to a central computer system of a lottery. The central computer system provides activation signals back to the point of sale on a ticket-by-ticket basis. The device, method and system provide automated generation and communication of ticket-by-ticket tampering, activation, and voiding data between the remote device and a central computer system of a lottery.

Abstract: A device, system, and method are provided for inspecting, activating or voiding scratch-off instant lottery tickets. A remote point-of-sale device has a detector system that detects tampering with the coating placed over concealed game play information on the tickets, and reads coded identification and authentication information on the tickets. The device automatically communicates the coded identification and tampering data to a central computer system of a lottery. The central computer system provides activation signals back to the point of sale on a ticket-by-ticket basis. The device, method and system provide automated generation and communication of ticket-by-ticket tampering, activation, and voiding data between the remote device and a central computer system of a lottery.

Abstract: A system allowing computers to be un-connected to the internet or networks generally while still allowing computers to share data on networks. By creating a one-way secure data link from a primary computer not connected to a network to a intermediate buffer computer which is network connected, the primary computer can distribute data via the buffer computer over the network without the risks associated with a direct connection to the internet or other networks.

Abstract: A device, system, and method are provided for inspecting, activating or voiding scratch-off instant lottery tickets. A remote point-of-sale device has a detector system that detects tampering with the coating placed over concealed game play information on the tickets, and reads coded identification and authentication information on the tickets. The device automatically communicates the coded identification and tampering data to a central computer system of a lottery. The central computer system provides activation signals back to the point of sale on a ticket-by-ticket basis. The device, method and system provide automated generation and communication of ticket-by-ticket tampering, activation, and voiding data between the remote device and a central computer system of a lottery.

Abstract: A head positioning device comprising: (A) a head support that is configured for supporting a patient's head; and (B) a sliding joint that is connected to allow the head support to be moved about a virtual axis of rotation while the head support is supporting the patient's head, wherein the virtual axis of rotation is spaced apart from the sliding joint. The head positioning device may include a head restraint for maintaining the patient's head in a substantially fixed relation to the head support as the head support is moved about the virtual axis of rotation. In one embodiment, the head restraint comprises a hook member that is configured for hookedly engaging a curved portion of the patient's face.

Abstract: A head positioning device comprising: (A) a head support that is configured for supporting a patient's head; and (B) a sliding joint that is connected to allow the head support to be moved about a virtual axis of rotation while the head support is supporting the patient's head, wherein the virtual axis of rotation is spaced apart from the sliding joint. The head positioning device may include a head restraint for maintaining the patient's head in a substantially fixed relation to the head support as the head support is moved about the virtual axis of rotation. In one embodiment, the head restraint comprises a hook member that is configured for hookedly engaging a curved portion of the patient's face.

Abstract: Disclosed herein are methods, devices and systems for accurately monitoring various pressures of a patient. The invention embodiments herein allow for taking into account pressure changes attributed to changes in elevation and tilt attitudes of the patient. Further disclosed herein is a unique and new pressure correction unit that comprises a tilt sensor affixed thereto or integrated therein.