Patents by Inventor Michael G. Goggins

Michael G. Goggins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aberrantly methylated genes in pancreatic cancer
    Patent number: 8785614
    Abstract: The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having the pancreatic carcinoma, thereby detecting pancreatic carcinoma in the subject.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: July 22, 2014
    Assignee: The Johns Hopkins University
    Inventors: Michael G. Goggins, Norihiro Sato
  • Methylated gene biomarkers for detecting cancer
    Patent number: 7879542
    Abstract: The present invention includes methods diagnosising of cancer by analysis of a patient sample, particularly for the presence of a methylated SPARC nucleic acid molecule, and particularly for the diagnosis of pancreatic cancer. The invention also includes therapeutic methods for treating cancers by administering to cancers patients therapeutically effective amounts of demethylating agents.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: February 1, 2011
    Assignee: The Johns Hopkins University
    Inventors: Michael G. Goggins, Sato Norihiro
  • Aberrantly Methylated Genes in Pancreatic Cancer
    Publication number: 20110003284
    Abstract: The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having the pancreatic carcinoma, thereby detecting pancreatic carcinoma in the subject.
    Type: Application
    Filed: January 9, 2009
    Publication date: January 6, 2011
    Inventors: Michael G. Goggins, Norihiro Sato
  • Aberrantly methylated genes in pancreatic cancer
    Patent number: 7485418
    Abstract: The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having the pancreatic carcinoma, thereby detecting pancreatic carcinoma in the subject.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: February 3, 2009
    Assignee: The Johns Hopkins University
    Inventors: Michael G. Goggins, Norihiro Sato
  • Differentially methylated sequences in pancreatic cancer
    Patent number: 7153653
    Abstract: The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having said cellular proliferative, thereby detecting a cellular proliferative disorder in the subject.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: December 26, 2006
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Michael G. Goggins, Takashi Ueki
  • Differentially methylated sequences in pancreatic cancer
    Publication number: 20030190616
    Abstract: The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having said cellular proliferative, thereby detecting a cellular proliferative disorder in the subject.
    Type: Application
    Filed: February 25, 2002
    Publication date: October 9, 2003
    Inventors: Michael G. Goggins, Takashi Ueki