Patents by Inventor Michael G. Surette

Michael G. Surette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUPPRESSING FALSE POSITIVES (TYPE I ERROR) DURING ANALYSIS OF SAMPLE BIOLOGICAL MATERIALS
    Publication number: 20220275440
    Abstract: A hybridization probe solution containing at least one hybridization probe is applied to final sample handling blank(s) to produce baited final sample handling blank(s), and identical hybridization probe is applied to final control blank(s) carrying transfer substrate identical to that applied to the sample handling blank(s) but isolated from the sample biological materials, to thereby produce at least one baited final control blank. The baited final sample handling blank(s) and baited final control blank(s) are fed into a DNA sequencer to sequence sample bait-captured DNA carried by the baited final sample handling blank and control bait-captured DNA carried by the baited final control blank, respectively. The sample bait-captured DNA is compared to the control bait-captured DNA and genetic components that are common to the final sample handling blank and the final control blank and pass a statistical significance test are discounted from a final identified genetic sequence.
    Type: Application
    Filed: August 21, 2020
    Publication date: September 1, 2022
    Inventors: Andrew MCARTHUR, Gerard D. WRIGHT, Hendrik POINAR, Michael G. SURETTE, Allison GUITOR
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 7666619
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: February 23, 2010
    Assignees: Princeton University, Quorex Pharmaceuticals, Inc., University Technologies International, Inc.
    Inventors: Bonnie L. Bassler, Stephan Schauder, Kevan Shokat, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 7326542
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: March 10, 2003
    Date of Patent: February 5, 2008
    Assignees: Princeton University, University Technologies International, Inc.
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 7323340
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: January 29, 2008
    Assignees: University Technologies International, Princeton University
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6942986
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: September 13, 2005
    Assignees: Princeton University, University Technologies International
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6936435
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: August 30, 2005
    Assignees: Princeton University, University Technologies Internat.
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6864067
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: March 8, 2005
    Assignees: University Technologies International, Princeton University
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6844423
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: January 18, 2005
    Assignees: Princeton University, University Technologies Transfer International
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Publication number: 20040180829
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Application
    Filed: March 17, 2004
    Publication date: September 16, 2004
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 6780890
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: August 24, 2004
    Assignees: University Technologies International, Inc., Quorex Pharmaceuticals, Inc., Princeton University
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette
  • COMPOUNDS AND METHODS FOR REGULATING BACTERIAL GROWTH AND PATHOGENESIS
    Publication number: 20040097402
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Application
    Filed: November 19, 2002
    Publication date: May 20, 2004
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Patent number: 6720415
    Abstract: This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: April 13, 2004
    Assignees: Princeton University, University Technologies International
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20040033548
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: March 10, 2003
    Publication date: February 19, 2004
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030166289
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: April 7, 2003
    Publication date: September 4, 2003
    Applicant: University Technologies International
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • COMPOSITIONS AND METHODS FOR REGULATING BACTERIAL PATHOGENESIS
    Publication number: 20030148414
    Abstract: This invention provides a purified extracellular bacterial autoinducer-2 signaling molecule, the production of which is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. The signaling molecule stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. This invention also provides is a new class of bacterial genes involved in the biosynthesis of the signaling molecule.
    Type: Application
    Filed: December 2, 1999
    Publication date: August 7, 2003
    Inventors: BONNIE L. BASSLER, MICHAEL G. SURETTE
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030104606
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: June 5, 2003
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030096376
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: May 22, 2003
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compositions and methods for regulating bacterial pathogenesis
    Publication number: 20030096330
    Abstract: The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.
    Type: Application
    Filed: September 21, 2001
    Publication date: May 22, 2003
    Inventors: Bonnie L. Bassler, Michael G. Surette
  • Compounds and methods for regulating bacterial growth and pathogenesis
    Patent number: 6559176
    Abstract: The invention provides autoinducer-2 analogs that regulate the activity of autoinducer-2 and methods of using such analogs for regulating bacterial growth and pathogenesis.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 6, 2003
    Assignees: Princeton University, Quorex Pharmaceuticals, Inc., University Technologies International, Inc.
    Inventors: Bonnie L. Bassler, Carol Dammel, Stephan Schauder, Kevan Shokat, Jeffrey Stein, Michael G. Surette
  • Methods for regulating bacteria
    Publication number: 20030022932
    Abstract: Bacteria lacking the ability to secrete autoinducer-2 may nonetheless be regulated by contacting the bacteria with an amount of an autoinducer-2 effector that is sufficient to regulate the bacterium. Pseudomonas aeruginosa, a bacterium that colonizes the lungs of cystic fibrosis patients with often devastating effects on health, is a preferred target for regulation.
    Type: Application
    Filed: May 17, 2002
    Publication date: January 30, 2003
    Inventors: Michael G. Surette, Jeffrey L. Stein