Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Abstract: A computer-aided image comparison, evaluation and retrieval system compares objects and object clusters, or images. User controlled or automatic filtering to enhance object features may be performed prior to object definition/detection. The query image may be substantially continuously displayed during the image filtering and object definition processes. Scoring to suspected biological, medical, chemical, physical or clinical condition may be performed based on retrieved objects or images and their relative similarities to the unknown.

Abstract: Disease or biomedical condition assessments or classifications are computed with scores from multiple different image modalities. Non-image information such as biometric, demographic, anthropomorphic and various risk factors may also be fused (combined) with one or more image modality disease or biomedical condition assessments or classifications to produce an integrated disease or biomedical condition assessment or suspicion score output and/or classification.

Abstract: A computer-aided image comparison, evaluation and retrieval system compares objects and object clusters, or images. User controlled or automatic filtering to enhance object features may be performed prior to object definition/detection. The query image may be substantially continuously displayed during the image filtering and object definition processes. Scoring to suspected biological, medical, chemical, physical or clinical condition may be performed based on retrieved objects or images and their relative similarities to the unknown.

Abstract: A computer-aided image comparison, evaluation and retrieval system compares objects and object clusters, or images. User controlled or automatic filtering to enhance object features may be performed prior to object definition/detection. The query image may be substantially continuously displayed during the image filtering and object definition processes. Scoring to suspected biological, medical, chemical, physical or clinical condition may be performed based on retrieved objects or images and their relative similarities to the unknown.

Abstract: An image comparison and retrieval system compares objects and object clusters, or images. User controlled or automatic filtering to enhance object features is performed, and object pixels are defined. An object characterization parameter is computed based on certain object pixel values that characterize one or more aspects of the defined object. Object characterization parameters are compared for objects in different images to produce a measure of object similarity in the same or different images. The query image may be substantially continuously displayed during the image filtering and object definition processes.

Abstract: A computer-aided image comparison, evaluation and retrieval system compares objects and object clusters, or images. User controlled or automatic filtering to enhance object features may be performed prior to object definition/detection. The query image may be substantially continuously displayed during the image filtering and object definition processes. Scoring to suspected biological, medical, chemical, physical or clinical condition may be performed based on retrieved objects or images and their relative similarities to the unknown.