Abstract: Novel peptoid oligomers are disclosed that have a formula represented by the following formula Ia or Ib: The peptoid oligomers are prepared as modulators of androgen receptor (AR), and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals, including humans, associated with unwanted or aberrant AR activity. The present peptoid oligomers are particularly valuable for the treatment of subjects with cancer.

Abstract: Methods and apparatuses for removing material (e.g., clot) from within a body, including inverting thrombectomy apparatuses. These methods and apparatuses may include methods and apparatuses for reusing portion of the devices, method and apparatuses for loading and reloading the inverting thrombectomy apparatuses, and methods and apparatuses for improving and enhancing the ability of the inverting thrombectomy apparatuses to remove clot.

Abstract: An assembly for cleaning material from a flowable product includes multiple stages of air cleaning for a product. Each air cleaning stage includes a vertical air column, an air knife, and at least one airlock. After introducing a product into the air column, the air knife disturbs material from the product and the material is carried away by the vertical air column. The airlock prevents significant disturbance of the vertical air column during operation. The cleaned product is delivered after a single cycle through the assembly having passed through several stages of cleaning.

Abstract: An assembly for cleaning material from a flowable product includes multiple stages of air cleaning for a product. Each air cleaning stage includes a vertical air column, an air knife, and at least one airlock. After introducing a product into the air column, the air knife disturbs material from the product and the material is carried away by the vertical air column. The airlock prevents significant disturbance of the vertical air column during operation. The cleaned product is delivered after a single cycle through the assembly having passed through several stages of cleaning.

Abstract: A grade sorting system and method. The grade sorting system is designed to sort items of various size grades into bins or other containers having items of similar size grades.

Abstract: The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.

Abstract: The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.

Abstract: The present invention includes a system of trays for containing leaking liquids above a ceiling. The trays have extended sides to hold a volume of liquid. One side of a tray is lower than other sides of the tray. When a large volume leak occurs, the liquid fills the tray to the height of the lower side and flows over the lower side into an adjacent tray. The system of trays includes a tray with a drain. The system of trays may also incorporate sensors in the trays. The sensors can operate to actuate a valve for shutting off the leaking liquid, and may also send a message communicating the occurrence of the leak.

Abstract: A leak detection system performs actions based upon the type and location of the detected leak. A plurality of sensors and sensor types are used at various locations in a building where leaks are likely to occur. Upon detection of a leak, a sensor transmits an RF signal identifying the sensor. A controller receives the RF signal and performs actions associated with the identifier for the sensor. Actions may include selectively closing or opening valves and electrical connections. Notifications are also sent by the system to building owners or occupants.

Abstract: A sensor system is used to detect water leaks caused by ice dams. The sensor system includes one or more water sensors having elongated leads. The elongated leads are placed inside the roof structure at locations where leaks are likely to occur. Upon detection of a leak, the sensor sends an RF or other signal to a receiver. The receiver provides a warning of the leak to the building owner or operator.

Abstract: A leak detection and control system provides for remote user control of devices in responding to detected leaks of other problems. A plurality of sensors and sensor types are used at various locations in a building where leaks are likely to occur. Upon detection of a leak, a sensor sends an RF signal identifying the sensor. A controller receives the RF signal and performs actions associated with the identifier for the sensor. Actions may include selectively closing or opening valves and electrical connections. Notifications are also sent by the system to building owners, occupants, maintenance personnel or operators. An operator can contact the controller from a remote location via a telephone system or a network to check status and to activate devices.

Abstract: A molecule containing the antigen binding portion of an antibody specific for human glucocorticoid receptor phosphorylated at residue Ser211, Ser226 or Ser203 is obtained and a method of determining the presence of activated glucocorticoid receptors in cells from human glucocorticoid responsive tissue and a method of screening for a glucocorticoid agonist using the molecule, which is preferably an antibody, are provided in the present invention.

Abstract: The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.

Abstract: A phosphorylation site-specific antibody that recognizes phosphorylated serine 213 within the N-terminus of the androgen receptor was obtained which can be used in methods for determining the presence of activated androgen receptors in cells or tissue of human androgen responsive tissue and for screening for an androgen inhibitor or an androgen agonist.

Abstract: A molecule containing the antigen binding portion of an antibody specific for human glucocorticoid receptor phosphorylated at residue Ser211, Ser226 or Ser203 is obtained and a method of determining the presence of activated glucocorticoid receptors in cells from human glucocorticoid responsive tissue and a method of screening for a glucocorticoid agonist using the molecule, which is preferably an antibody, are provided in the present invention.

Abstract: The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.

Abstract: The present invention also provides a method for screening and isolating transcriptional coregulatory proteins of transcription factors. Using this method, a new class of proteins, androgen receptor transcriptional coregulatory proteins, that interact with the androgen receptor N-terminus to regulate transcriptional activation, which are targets for identifying and isolating inhibitors that disrupt such an interaction, were identified.